Does Diazepam cause weight gain

Does Diazepam cause weight gain?

If you are a woman, so you get afraid of weight gaining.

What if the physician prescribed you Diazepam?

Does Diazepam cause weight gain?

Well, let’s get to know diazepam first.

What is Diazepam?

Diazepam is a long-acting drug belonging to the benzodiazepines family.

It has anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties.

Uses and indications:

Diazepam has many uses and indications due to its calming effect on the brain.

Diazepam is used in relieving anxiety, controlling agitation happening due to alcohol withdrawal.

It is also used in addition to other medicines to control muscles spasms and spasticity (damage happening to the pathways of nerves in the brain and spinal cord, causing an abnormal increase in muscle tone or stiffness of the muscles, interfering with movement, speech, and may be associated with discomfort or pain).

Spasticity may occur by certain neurological disorders, like cerebral palsy (inability to move and keep balance and posture), paraplegia (an injury in the spinal cord resulting in paralysis of the lower limbs), athetosis (involuntary muscle movements that may be continuous, slow, and rolling), and stiff-man syndrome (stiffness in the muscles of the trunk and abdomen, the stiffness may be constant and may come and go).

Diazepam is also used in controlling seizures in combination with other medicines.

Dosing and administration and knowing Does Diazepam cause weight gain:

Diazepam is a drug that is available in many dosage forms with many concentrations.

It makes it very convenient for you that you can choose the most suitable dosage form for you.

In the treatment of anxiety

The oral form and the IV/IM is 2 to 10 mg every 6 to 12 hours

The maximum dose is 30 mg every 8 hours

In the management of agitation associated with alcohol withdrawing

The oral form is 10 mg every 6 to 8 hours during the first 24 hours, and then the dose is reduced to 5 mg every 6 to 8 hours

The IV/IM form is 10 mg initially, and additional doses of 5 to 10 mg IV every 6 to 8 hours as needed

To induce sedation before endoscopy

The IV form is 10 mg titrated or less immediately before procedure, the cumulative dose not to exceed 20 mg, in the same time; the dose of narcotics is reduced by one third.

The IM form is 5 to 10 mg 30 minutes before the procedure

 

To induce sedation before having surgery

The IM for is 10 mg before the surgery

In the relaxation of muscle spasms

The oral form is 2 to 10 mg every 6 to 8 hours

The IV/IM form is 5 to 10 mg initially and then every 3 to 4 hours as needed

In the management of seizures

The oral form is 2 to 10 mg every 6 to 12 hours as an adjunctive therapy

The parenteral solution (solutions, suspensions, and emulsions prepared for injection or infusion) is 0.2 mg/kg and then repeated after 4 to 12 hours when needed

In the management of status epilepticus

The IV/IM is 5 to 10 mg every 5 to 10 minutes, and the dose not to exceed 30 mg

The parenteral solution is 0.5 mg/kg and then 0.25 mg/kg in 10 minutes

Dosage modifications:

Renal impairment: No need for adjusting the dose unless administered for a long period, the dose is decreased

Hepatic impairment: 50 % of maintenance dose is taken

 

Interactions:

Diazepam and benzodiazepines can interact with food, alcohol, and drugs.

Drug-drug interactions

Drugs causing serious interactions when concomitantly used with diazepam, and an alternative drug should be used.

• abametapir
• apalutamide
• benzhydrocodone/acetaminophen
• calcium/magnesium/potassium/sodium oxybates
• carbamazepine
• cimetidine
• clarithromycin
• darunavir
• erythromycin base
• erythromycin ethylsuccinate
• erythromycin lactobionate
• erythromycin stearate
• fedratinib
• hydrocodone
• idelalisib
• ivosidenib
• ketoconazole
• lonafarnib
• metoclopramide intranasal
• mifepristone

• nefazodone

• rifabutin
• rifampin
• selinexor
• sodium oxybate
• St John’s Wort
• sufentanil SL
• tipranavir
• tucatinib
• valerian
• voxelotor

There is another list of drugs needing close monitoring when concomitantly used with diazepam, take care if you are not going to change one of them.

Drug-alcohol interactions

Alcohol with diazepam increases sleepiness and sleeping difficulty to be wakening from.

It may also cause really serious breathing problems.

Drug-food interactions

Grapefruit counteracts the elimination of diazepam causing the increase of diazepam concentration in the blood.

Avoid eating grapefruit and drinking grapefruit juice while taking diazepam.

Caffeine is known to be a stimulant reducing the calming effects of diazepam.

Avoid drinking coffee, tea, and cola during the treatment with diazepam as they contain caffeine.

Does diazepam cause weight gain?

The researchers found that diazepam taking for up to 10 months led to weight gain while stopping it led to weight loss.

However, it is not recommended to use diazepam in gaining weight as it may cause abuse and addiction.

So, does diazepam cause weight gain?

Yes, it does cause weight gain, so take care when using it for a long period more than 10 months.

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