How long is diazepam in your system

How long is diazepam in your system?

When does the drug start to work? When does it start to give the intended effect? Then, when does this effect fade?

All of this happens depending on how fast does your body absorbs the medication? How does the body distribute it? How the body breaks it down?

Some medications like antihypertensive drugs (drugs used to lower your high blood pressure), such as metoprolol, work on the same day they are taken in, also, H2 blockers (drugs used to treat heartburn by blocking the cells responsible for secreting the stomach’s acid), such as famotidine.

However, other medications take a longer time to work, such as statins used for lowering the cholesterol levels, like atorvastatin, which may take from two to four weeks.

A drug like Sertraline, a medication used to treat depression; it may take up to months to give the full effect.

So, how long is diazepam in your system?

Diazepam is a benzodiazepine, working on certain neurotransmitters in the brain; these neurotransmitters are called GABA (Gamma amino-butyric acid), which produces a calming effect on the brain and nerves.

What is diazepam used for?

Diazepam is helpful in the management of anxiety symptoms, alcohol withdrawal symptoms, and seizures.

It is also used in the relaxation of muscle spasms and to provide sedation before surgeries or in the ICU (intensive care unit).

How to use diazepam?

Before taking any medication, read the medication guide provided with the drug carefully, and ask your health care provider about any information that you can’t fully understand.

Take diazepam exactly as prescribed by your doctor, and don’t share it with others.

The doctor determines the dose according to the severity of the medical condition, age, and weight of the patient.

However, there are regular doses for each medical condition it is used to treat.

Anxiety

2 to 10 mg orally or by intravenous/intramuscular injection 2 to 4 hours per day

Maximum dose: 30 mg 3 times per day

Alcohol withdrawal

10 mg orally 3 to 4 times during the first day, then the dose is decreased to 5 mg 3 to 4 times per day

If you are going to use the intravenous/intramuscular, 10 mg is a used, then an additional dose of 5 to 10 mg 3 to 4 times if needed

Endoscopy

IV method: The dose is titrated to 10 mg or less before the procedure

The cumulative dose should not exceed 20 mg

The great thing about using diazepam is that it helps in reducing the dose of narcotics by one third

IM method: from 5 to 10 mg 30 minutes before the procedure

Preoperative sedation

10 mg intramuscularly before surgery

Sedation in the ICU

5 to 10 mg intravenously, then 0.03 to 0.1 mg/kg every 30 minutes to 6 hours

Muscle spasms

2 to 10 mg orally 3 to 4 times per day or 5 to 10 mg intravenously or intramuscularly initially, then every 3 to 4 hours if needed

Drug-drug interactions

The FDA (Food and drug administration) has issued a black box warning about the use of diazepam with opioid medications, the concomitant use may result in profound sedation, respiratory depression, coma, and death.

Diazepam may cause serious interactions if used with these drugs, use an alternative

• abametapir
• apalutamide
• benzhydrocodone/acetaminophen
• calcium/magnesium/potassium/sodium oxybates
• carbamazepine
• cimetidine
• clarithromycin
• darunavir
• erythromycin base
• erythromycin ethylsuccinate
• erythromycin lactobionate
• erythromycin stearate
• fedratinib
• fexinidazole
• hydrocodone
• idelalisib
• ivosidenib
• ketoconazole
• lonafarnib
• metoclopramide intranasal
• mifepristone

There is a list of other drugs that need close monitoring when used with diazepam, always tell your doctor about the drugs you are using before letting him prescribing you a new one.

How long is diazepam in your system?

Diazepam is a fast-acting drug.

When it is taken intravenously, it starts to work within 1 to 3 minutes, but if it is taken orally it takes between 15 to 60 minutes to work.

Diazepam is well absorbed about more than 90 % when taken orally.

How long is diazepam in your system?

Diazepam is a long-lasting drug.

It has a half-life of approximately 48 hours; the half-life is the time for half the dose to get from the body.

How long is diazepam in your system?

Metabolites (the substances produced from the breaking down of diazepam in the body) of diazepam can be detected in different ways.

Urine

Diazepam is detected in urine from 1 to 6 weeks.

Blood

Diazepam is detected in blood from 6 to 48 hours.

Saliva

Diazepam is detected in saliva from 1 to 10 days.

Hair

Diazepam is detected in the hair follicle for up to 90 days.

Finally, diazepam is a well-studied drug, which has proved very good effectiveness and a good range of safety.

Always discuss with your doctor the information you read in a medical article.

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