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Home/Pharma information/Lyrica pregabalin

Lyrica pregabalin

Posted by : admin / On : October 8, 2021 / In : Pharma information
Lyrica pregabalin

Table of Contents

  • Lyrica pregabalin
    • What are Lyrica pregabalin indications?
    • What are the adverse effects of Lyrica pregabalin?
      • Most serious adverse effects, need to call your doctor immediately and stop medication:
    • Lyrica pregabalin warnings and precautions:
    • Lyrica pregabalin and other medications interactions:
      • Lyrica pregabalin may increase the effect of the following medications:
    • Before starting Lyrica pregabalin:
    • Things should be avoided during treatment with Lyrica pregabalin:
    • Special populations and use of Lyrica pregabalin:
    • Lyrica pregabalin dosage and strengths:
    • How to use Lyrica pregabalin?
    • Lyrica pregabalin overdose:
      • Overdosing of Lyrica may cause by:
      • Overdosing signs and symptoms:
      • Overdosing management:

Lyrica pregabalin

  • Lyrica is a brand name of an active ingredient called pregabalin.
  • Lyrica pregabalin is one of the most common medications in treatment seizures so it is known as an anticonvulsant medication.
  • Also due to anti-anxiety effect, known as anxiolytic.
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What are Lyrica pregabalin indications?

Due to its pharmacological activity, there are many indications:

  • Certain types of seizures (anticonvulsant).
  • Neuropathic pain: one of the diabetic complications causing severe nerve pain.
  • Spinal cord injury associated with neuropathic pain.
  • Postherpetic neuralgia: post herpes zoster infection.
  • Fibromyalgia: as an alternative agent for a patient who does not respond or tolerate preferred agents.
  • Generalized anxiety disorder.

Lyrica pregabalin

What are the adverse effects of Lyrica pregabalin?

Lyrica pregabalin adverse effects:

 

  • Blurred vision.
  • Chest pain.
  • Hypertension or hypotension.
  • Contact dermatitis.
  • Decreased libido.
  • Abdominal pain.
  • Weight gain.
  • Dry mouth.

Most serious adverse effects, need to call your doctor immediately and stop medication:

  • Severe allergic reaction.
  • Severe dizziness.
  • Trouble breathing.
  • Suicidal attempt.
  • Mental problems.
  • Unusual change in your mood.

Lyrica pregabalin warnings and precautions:

Warnings and precautions of Lyrica pregabalin:

  • Hypersensitivity: allergic reaction to Lyrica pregabalin, including skin redness, rash, dyspnea, and wheezing.
  • Respiratory depression: which is a serious life-threatening condition. This risk increases with chronic obstructive pulmonary disease and in the elderly.
  • Cardiovascular disease: Use with caution in heart failure patients.
  • Renal impairment: use with caution and dosage adjustment is required.
  • Peripheral edema: common adverse effect, so use with cautions in a patient with heart failure, and concomitant use of medications causing weight gain or peripheral edema.

Lyrica pregabalin and other medications interactions:

Revise all your medications before starting Lyrica pregabalin with your doctor.

Many drug-drug interactions may occur, so a dose adjustment may require.

Examples of these interactions:

Medications avoid concomitant use of pregabalin:

Medications decrease the effect of pregabalin:

Medications increase effects of pregabalin:

 

  • Kava-kava.
  • Magnesium sulfate.

Lyrica pregabalin may increase the effect of the following medications:

 

  • CND depressants.
  • Oxybate salt products.

Before starting Lyrica pregabalin:

You need to tell your doctor if you have one of the following medical conditions before starting Lyrica pregabalin:

  • Heart problem: especially heart failure.
  • Bleeding disorders: like thrombocytopenia (low platelets level).
  • Lung disease: like a chronic obstructive pulmonary disease.
  • Suicidal thoughts.
  • Renal impairment.
  • Drugs or alcohol abuse.
  • Severe allergic and hypersensitivity reactions.

Things should be avoided during treatment with Lyrica pregabalin:

  • Avoid driving.
  • Avoid operate machinery.
  • Avoid drinking alcohol.
  • Avoid stopping Lyrica suddenly.
  • Avoiding the use if you had a previous allergy history.

Special populations and use of Lyrica pregabalin:

There are many concerns of using Lyrica pregabalin in certain populations:

  • Elderly: Lyrica should be used with caution in the elderly and dosage adjustment is required, so starting with the lowest dose is mandatory.
  • Pediatric: Lyrica not approved in pediatric at age below 18.
  • Pregnant: use of Lyrica in some cases may be necessary to control seizures, your doctor will help you to make a decision.
  • Breast-feeding: it is not recommended to use Lyrica in breastfeeding.
  • Renal impairment: use of Lyrica in renal impairment required specific dose adjustment according to the degree of impairment.
  • Cardiac patients: use with caution especially with a congestive heart patient.

Lyrica pregabalin dosage and strengths:

Lyrica is available in many forms:

 

  • Oral solutions.

Many strengths are available:

  • Capsules: there are capsules contains 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, and 300mg.
  • Oral solutions: 20mg/ml.
  • Tablets: extended-release tablets 24 hour 82.5mg, 165mg, 330mg.

How to use Lyrica pregabalin?

  • Take Lyrica by your mouth as your doctor’s instructions.
  • You can use Lyrica with or without meals.
  • You should swallow the whole tablet.
  • You should not crush or chew tablets.
  • You should take it at the same scheduled time.
  • You should not stop the medication suddenly, need to tapper the dose under the supervision of your doctor.
  • You should avoid drinking alcohol during use of Lyrica.
  • You should store away from heat and light.
  • If you missed dose, you should take it immediately. Only skipped if it is a time of the scheduled dose.

Lyrica pregabalin overdose:

Overdosing of Lyrica may cause by:

  • Ingestion of too much dose.
  • Concomitant use of medications increases the effects of Lyrica and may cause toxicity.

Overdosing signs and symptoms:

 

  • Reduced consciousness.
  • Trouble breathing.
  • Heart block.

Call your doctor immediately and visit the emergency department of the nearest hospital.

Overdosing management:

Under the supervision of healthcare provider in hospital:

  • induce emesis and gastric lavage.
  • Maintain the airway.
  • Monitoring vital signs.
  • Lyrica may be removed by hemodialysis.
  • There is no antidote for Lyrica.

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