- Lyrica is a brand name of an active ingredient called pregabalin.
- Lyrica pregabalin is one of the most common medications in treatment seizures so it is known as an anticonvulsant medication.
- Also due to anti-anxiety effect, known as anxiolytic.
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What are Lyrica pregabalin indications?
Due to its pharmacological activity, there are many indications:
- Certain types of seizures (anticonvulsant).
- Neuropathic pain: one of the diabetic complications causing severe nerve pain.
- Spinal cord injury associated with neuropathic pain.
- Postherpetic neuralgia: post herpes zoster infection.
- Fibromyalgia: as an alternative agent for a patient who does not respond or tolerate preferred agents.
- Generalized anxiety disorder.
What are the adverse effects of Lyrica pregabalin?
Lyrica pregabalin adverse effects:
- Blurred vision.
- Chest pain.
- Hypertension or hypotension.
- Contact dermatitis.
- Decreased libido.
- Abdominal pain.
- Weight gain.
- Dry mouth.
Most serious adverse effects, need to call your doctor immediately and stop medication:
- Severe allergic reaction.
- Severe dizziness.
- Trouble breathing.
- Suicidal attempt.
- Mental problems.
- Unusual change in your mood.
Lyrica pregabalin warnings and precautions:
Warnings and precautions of Lyrica pregabalin:
- Hypersensitivity: allergic reaction to Lyrica pregabalin, including skin redness, rash, dyspnea, and wheezing.
- Respiratory depression: which is a serious life-threatening condition. This risk increases with chronic obstructive pulmonary disease and in the elderly.
- Cardiovascular disease: Use with caution in heart failure patients.
- Renal impairment: use with caution and dosage adjustment is required.
- Peripheral edema: common adverse effect, so use with cautions in a patient with heart failure, and concomitant use of medications causing weight gain or peripheral edema.
Lyrica pregabalin and other medications interactions:
Revise all your medications before starting Lyrica pregabalin with your doctor.
Many drug-drug interactions may occur, so a dose adjustment may require.
Examples of these interactions:
Medications avoid concomitant use of pregabalin:
Medications decrease the effect of pregabalin:
Medications increase effects of pregabalin:
- Magnesium sulfate.
Lyrica pregabalin may increase the effect of the following medications:
- CND depressants.
- Oxybate salt products.
Before starting Lyrica pregabalin:
You need to tell your doctor if you have one of the following medical conditions before starting Lyrica pregabalin:
- Heart problem: especially heart failure.
- Bleeding disorders: like thrombocytopenia (low platelets level).
- Lung disease: like a chronic obstructive pulmonary disease.
- Suicidal thoughts.
- Renal impairment.
- Drugs or alcohol abuse.
- Severe allergic and hypersensitivity reactions.
Things should be avoided during treatment with Lyrica pregabalin:
- Avoid driving.
- Avoid operate machinery.
- Avoid drinking alcohol.
- Avoid stopping Lyrica suddenly.
- Avoiding the use if you had a previous allergy history.
Special populations and use of Lyrica pregabalin:
There are many concerns of using Lyrica pregabalin in certain populations:
- Elderly: Lyrica should be used with caution in the elderly and dosage adjustment is required, so starting with the lowest dose is mandatory.
- Pediatric: Lyrica not approved in pediatric at age below 18.
- Pregnant: use of Lyrica in some cases may be necessary to control seizures, your doctor will help you to make a decision.
- Breast-feeding: it is not recommended to use Lyrica in breastfeeding.
- Renal impairment: use of Lyrica in renal impairment required specific dose adjustment according to the degree of impairment.
- Cardiac patients: use with caution especially with a congestive heart patient.
Lyrica pregabalin dosage and strengths:
Lyrica is available in many forms:
- Oral solutions.
Many strengths are available:
- Capsules: there are capsules contains 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, and 300mg.
- Oral solutions: 20mg/ml.
- Tablets: extended-release tablets 24 hour 82.5mg, 165mg, 330mg.
How to use Lyrica pregabalin?
- Take Lyrica by your mouth as your doctor’s instructions.
- You can use Lyrica with or without meals.
- You should swallow the whole tablet.
- You should not crush or chew tablets.
- You should take it at the same scheduled time.
- You should not stop the medication suddenly, need to tapper the dose under the supervision of your doctor.
- You should avoid drinking alcohol during use of Lyrica.
- You should store away from heat and light.
- If you missed dose, you should take it immediately. Only skipped if it is a time of the scheduled dose.
Lyrica pregabalin overdose:
Overdosing of Lyrica may cause by:
- Ingestion of too much dose.
- Concomitant use of medications increases the effects of Lyrica and may cause toxicity.
Overdosing signs and symptoms:
- Reduced consciousness.
- Trouble breathing.
- Heart block.
Call your doctor immediately and visit the emergency department of the nearest hospital.
Under the supervision of healthcare provider in hospital:
- induce emesis and gastric lavage.
- Maintain the airway.
- Monitoring vital signs.
- Lyrica may be removed by hemodialysis.
- There is no antidote for Lyrica.