Sildenafil prescribing restrictions

Sildenafil prescribing restrictions

Erectile dysfunction is a very irritating and embarrassing problem that affects men, especially men older than 40 years old.

Erectile dysfunction is also known as impotence, means that men can’t get or keep a firm penis that is enough for having sexual activity.

Sildenafil is a very famous and effective drug used for the treatment of this condition, but like any other drug sildenafil prescribing restrictions do exist.

Sildenafil belongs to a family of medicines called phosphodiesterase 5 inhibitors (PDE5).

This family prevents the phosphodiesterase type-5 enzyme from working too quickly, this enzyme works in many areas especially the penis which maintains the erection and controls the erectile dysfunction.

Sildenafil is also used for pulmonary arterial hypertension in both men and women.

Pulmonary arterial hypertension is a kind of hypertension (high blood pressure) that happens between the heart and the lungs, which makes the heart works much harder to pump blood through the lungs.

Sildenafil prescribing restrictions include many aspects.

Allergies:

You have to inform your doctor if you have ever suffered from any kind of allergy towards sildenafil or its family.

You have also to inform him about any other types of allergies like foods, dyes, preservatives, or animals.

Pediatrics:

Sildenafil should not be used in children for pulmonary arterial hypertension especially if it is going to be used for a long time.

Geriatrics:

Sildenafil prescribing restrictions may extend to elders with age-related liver, kidney, or heart problems, because they may need adjustments of doses.

Breastfeeding:

There are not enough data about the use of Sildenafil in nursing mothers, so the health care provider should outweigh the benefits and risks before giving the drug to the mother.

Sildenafil prescribing restrictions also include the drugs the patient is taking as some medications may cause serious interactions when concomitantly used with others.

Drug-drug interactions:

Drug-drug interactions may include contraindicated drugs, drugs causing serious interactions and an alternative drug should be used, and finally drugs should be monitored when used in combination with Sildenafil.

Contraindicated drugs

• atazanavir
• cobicistat
• elvitegravir/cobicistat/emtricitabine/tenofovir DF
• isosorbide dinitrate
• isosorbide mononitrate
• nelfinavir
• nitroglycerin IV
• nitroglycerin PO
• nitroglycerin rectal
• nitroglycerin sublingual
• nitroglycerin topical
• nitroglycerin transdermal
• nitroglycerin translingual
• riociguat
• vericiguat

Serious – use alternative

• abametapir
• alfuzosin
• amyl nitrite
• apalutamide
• asenapine
• chloramphenicol
• clarithromycin
• conivaptan
• crizotinib
• dabrafenib
• doxazosin
• eslicarbazepine acetate
• glyceryl trinitrate pr
• ivosidenib
• ketoconazole
• lonafarnib
• lopinavir
• mifepristone
• mitotane
• nafcillin
• ombitasvir/paritaprevir/ritonavir & dasabuvir
• oxcarbazepine
• pentobarbital
• phenobarbital
• phenoxybenzamine
• phentolamine
• phenytoin

Sildenafil prescribing restrictions include some medical problems like,

• Birth defects in the Penis
• Severe chest pain (Angina)
• Irregular heartbeats during the last 6 months (Arrhythmia)
• Problems in the blood vessels like aortic stenosis
• Heart attack
• Heart failure
• Hypertension or hypotension
• Retinal disorders (an eye disorder)
• Retinitis Pigmentosa (a genetic eye disorder)
• Stroke during the last 6 months
• Coronary artery disease
• Diabetes

This is not a full list of medical conditions, always tell your doctor about the medical conditions you are suffering from.

Like many drugs, sildenafil may cause several side effects.

Side effects:

Side effects differentiate between common, less common, and rare side effects.

Common side effects

• muscles aches
• bleeding nose
• diarrhea
• difficult breathing
• flushing
• headache
• painful or tendered eyes or cheekbones
• skin redness
• sneezing
• stomach discomfort especially after meals
• stuffy or runny nose
• sleeping troubles (Insomnia)
• unusually warm skin

Less common side effects

• pain in the bladder
• burning in the chest or stomach
• feelings like burning, crawling, itching, numbness, prickling, or tingling
• cloudy or bloody urine
• dizziness
• increased urination
• digestion problems
• pain on urination
• upset stomach
• tenderness in the stomach

These side effects may persist or may go on their own, if you have persistent side effects, consult with your doctor for decreasing the dose or stopping the drug.

Proper use of Sildenafil:

Before taking Sildenafil, make sure to read the medication guide carefully to avoid misuse of the drug.

Sildenafil is not affected by food; you can take it with or without food.

It is usually taken about 1 hour before sexual activity, but it can be taken from 30 minutes to 4 hours before.

Dosing:

The dose of Sildenafil is based on the medical condition, age, and weight of the patient.

But still, there are usual doses for Sildenafil.

For the treatment of erectile dysfunction:

• Adults:

50 mg only once a day, 1 hour before sexual intercourse

• Elders:

25 mg only once a day, 1 hour before sexual intercourse

For the treatment of pulmonary arterial hypertension:

• Adults:

The dose is started with 5 mg and may be increased to 20 mg three times a day

• Children:

The dose and frequency are determined by the doctor

 

Storage:

Sildenafil is stored in a closed container at the temperature of the room.

Keep it out from children.

Sildenafil is a very effective and potent drug, but there are some sildenafil prescribing restrictions that you have to take care of it.

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Sildenafil prescribing restrictions