Lyrica medication side effects

Lyrica medication side effects:

What are Lyrica medication’s side effects?

Lyrica: is a medication that contains an active ingredient called pregabalin. Pregabalin is one of the most common anticonvulsant medications. Besides its activity pregabalin is commonly known as anxiolytic.

Side effects: undesirable effects of medications, may in some cases need to stop the medication.

Indications of Lyrica medication side effects:

Uses of Lyrica:

• Neuropathic pain: nerves pain as a complication of long-term diabetes.
• Certain types of seizure: that’s why Lyrica is known as an anticonvulsant.
• Postherpetic neuralgia: nerves pain after herpes zoster infection.
• Fibromyalgia: Lyrica is considered an alternative agent in the treatment of fibromyalgia.
• Generalizes anxiety disorder: so, Lyrica is known as anxiolytic.
• Spinal cord injury: neuropathic pain is common due to spinal cord injury.

Lyrica medication side effects:

Many side effects of Lyrica you may feel once start treatment, refer to your doctor and discuss continue of medications, modify the dose, or discontinue according to the severity of side effects.

 

• Hypotension or hypertension.
• Abdominal pain.
• Contact dermatitis.
• Weight gain.
• Blurred vision.
• Chest pain.
• Decreased libido.
• Dry mouth.

Severe adverse effects may occur in rare cases like:

 

• Severe allergic reaction.
• Trouble breathing.
• Mental problems.
• Suicidal attempts.
• Severe dizziness.
• Unusual change in your mood.

Lyrica medication side effects, dosages, and strengths:

Many dosages form of Lyrica is found in the market in different strengths:

• Capsules form: many different strengths, 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg.
• Oral solutions form: available in strength 20mg/ml.
• Oral tablets form: it’s an extended-release tablet available in strength 82.5mg, 165mg, 330mg.

How to use Lyrica medication side effects?

You should follow your doctor’s instructions:

• You should take Lyrica by your mouth.
• You should not crush or chew your tablets.
• You should swallow the whole tablet.
• You should take it in a scheduled manner.
• You can take with or without food.
• You should keep it away from heat and light.
• You should not stop it suddenly.
• You should avoid drinking alcohol in concomitant use with Lyrica.

Lyrica medication side effects warnings and precautions:

Warnings and precautions of using Lyrica include the following conditions:

• Cardiovascular disorders: use of Lyrica is cautious in case if you suffer from congestive heart failure.
• Peripheral edema: most common adverse effect of Lyrica especially concomitant use of medications causing weight gain and if you suffer from heart failure.
• Severe allergic and hypersensitivity reactions: if you have an allergy to Lyrica, you may feel skin redness, skin rash, wheezy, or dyspnea.
• Renal impairment: if you have renal impairment, you should tell your doctor as there is a need to adjust and modify your dose.
• Respiratory depression: which is a life-threatening condition and occurs in elderly patients, or patients who have a chronic obstructive pulmonary disease.

Medical conditions you need to tell your doctor before starting Lyrica medication side effects:

• If you have heart problems especially congestive heart failure.
• If you have depression.
• If you have renal impairment.
• If you have suicidal thoughts.
• If you have a severe allergic reaction.
• If you have a lung disease like chronic obstructive pulmonary disease.
• If you have a bleeding disorder like thrombocytopenia which is a condition of low platelets count.

Lyrica medication side effects overdosing:

Overdosing of Lyrica may occur if:

• Ingestion of too much Lyrica dose.
• Use of concomitant medications that interact with Lyrica and increase its efficacy.

Signs and symptoms of Lyrica overdosing:

 

• Trouble breathing.
• Reduced consciousness.
• Heart block.

You should immediately stop a medication, calling your doctor, and visit the nearest emergency department if you feel one of the previous symptoms.

Things you should never do when you start the use of Lyrica medication side effects:

• You should not drive.
• You should not operate machinery.
• You should not drink alcohol.
• You should not use it if you have a previous history of allergy.
• You should not stop suddenly.

Lyrica interactions with other medications:

You should revise your medication with your doctor as if there is any interaction, you may need to adjust your dose:

Examples of interaction that may occur with Lyrica:

Medications should avoid concomitant use with Lyrica:

 

Medications increase the effect of Lyrica:

 

• Kava-kava.
• Magnesium sulfate.

Medications decrease the effect of Lyrica:

Besides all previous interactions, Lyrica may affect the efficacy and safety of other medications like:

• CNS depressant.
• Oxybate salt products.

Lyrica in pregnancy and lactation:

• Pregnancy: under the supervision of your doctor use of Lyrica should outweigh risk, like in some cases to control seizures.
• Lactation: Lyrica should be avoided to use in lactating women.

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9 things you should know about Lyrica medication

 

Lyrica pill

 

What is Lyrica

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Lyrica pill

Lyrica (pregabalin) the FDA approved drug for use with convulsions, became now a critical neuropathic pain reliever. Buy Lyrica pills online safely.

 

Know What’s Lyrica, use and possible drug interactions.

What is Lyrica?

Lyrica is a brand name of a prescription medication called pregabalin. It’s an FDA-approved medication. It’s indicated for use in adults with the following conditions:

 

• diabetic neuropathic pain
• neuropathic pain from a spinal cord injury
• fibromyalgia (a rheumatic condition distinguished by musculoskeletal pain)
• neuropathic pain after shingles
• partial-onset seizures (as adjuvant therapy with other seizure drugs)

How long does it take to work?

Lyrica pills begin to work very fast. Almost as soon as you take your dose. However, your pain may not be relieved instantly.

 

Some studies showed that some adults taking this medication reported a decrease in pain within 7 days of starting treatment. You may still need several weeks on this medication to feel that your symptoms are relieved.

 

How long does Lyrica stay in your system?

After taking the last dose, Lyrica can stay in your body for about 31 hours.

 

Lyrica in specific populations

Pregnant women

There are no adequate reports and well-controlled studies on Lyrica pill use in pregnant women. However, it could be given during pregnancy when there are no alternatives to the underlining case and benefits outweigh the risks.

 

Studies on animals have shown increased incidences of fetal structural and functional abnormalities. The fetus might be at risk of skeletal malformations, retarded ossification, and decreased fetal body weight.

 

Women using Lyrica should be informed of the potential risk to a fetus.

 

Fertile Women should be advised to use reliable contraception during treatment with this medication.

 

Breastfeeding women

It’s thought that 7% of the maternal weight-adjusted dose will be excreted in breast milk.

 

Breastfeeding while using these Lyrica pills is not recommended.

Animal Studies showed tumorigenicity in 2 different strains of mice.

 

Due to the potential risk of carcinogenicity, mothers who are breastfeeding their babies shouldn’t take this medication.

 

Geriatric

In controlled clinical studies of pregabalin in neuropathic pain associated with diabetic peripheral neuropathy, neuropathic pain associated with postherpetic neuralgia and epilepsy, it’s found that No overall differences in safety and efficacy were observed between patients older than 75 years old and younger patients.

 

In controlled clinical studies of LYRICA in fibromyalgia, the adverse reaction profile was similar between the two age groups, but some side effects were more frequent in patients 65 years or older. These side reactions include a balance disorder, dizziness, tremor, confusional state, blurred vision, and coordination abnormality.

 

Lyrica pill is mainly excreted by the kidney. Patients with impaired renal function may be at higher risk of toxicity.

 

The dosing should be modified for older patients with renal impairment.

 

 

Lyrica interactions

 

Lyrica, like any medication, can cause interactions with other substances taken by the patient (drug, alcohol or even food).

Before taking this medication, inform your doctor and pharmacist of all the medications you use, (including prescription drugs, nonprescription drugs, vitamins, supplements and herbal medicines).

Detailed information can help you avoid potential interactions.

 

Here is a list of medications that may interact with Lyrica pills. This list includes but is not limited to:

 

Lyrica and CNS depressants

Your CNS (your brain and spinal cord) could be affected by Lyrica. To help understand, your brain sends signals throughout your body through nerves originated from the spinal cord.

A CNS depressant (such as Lyrica) works by slowing down your CNS. This may cause side effects such as sedation, drowsiness and respiratory depression. Other CNS depressants affect your body in the same way. Combining two or more CNS depressants exaggerates the sedative effect of each other.

 

Some examples of CNS depressants include:

 

• opioid medications (pain killers)
• benzodiazepines (alprazolam, diazepam,.. etc)
• diphenhydramine
• muscle relaxers like cyclobenzaprine and baclofen

 

Before you take Lyrica pills, tell your doctor if you’re using any of the previous drugs.

You probably will be monitored for any symptoms of increased sedation or respiratory problems during your treatment period.

Your doctor may decide to alter your medication doses or try different drugs for your condition.

 

Lyrica and alcohol

Lyrica shouldn’t be taken while drinking alcohol. Alcohol is a central nervous system sedative.

Combining the two substances could raise your risk for certain neurogenic side effects, such as drowsiness, sleepiness, dizziness, and respiratory depression.

Before you begin treatment with Lyrica, Tell your doctor if you drink alcohol.

 

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This is a part of what you should know about Lyrica pills.

Ask your doctor and pharmacist for further explanation and make sure that the information here is suitable for your circumstances.

Lyrica capsules

Lyrica dosage

What is Lyrica

Lyrica dosage

The dosage of a drug is how many times you are taking the amount and number of the intended drug over a specific period.

Lyrica dosage depends on the specific medical condition it is taken for, and the severity of it.

It also depends on the age, weight, and general health of the patient.

What is Lyrica?

Lyrica is generically known as Pregabalin, is approved by the FDA (Food and Drug Administration) to work as an anti-epileptic drug (anticonvulsant), and for other indications also.

How does Lyrica work?

Lyrica works by inhibiting the brain impulses causing seizures.

It also affects the chemicals responsible for sending the signals of pain across the nervous system.

So, based on the mechanism of action, What is Lyrica used for?

Lyrica is used for,

• Diabetic peripheral neuropathic pain

It is damage to the nerves throughout the body that can occur with diabetes especially the nerves of the legs and feet.

• Postherpetic neuralgia

The most common complication happening due to shingles is postherpetic neuralgia.

It causes severe pain (burning pain) as it affects the nerve fibers and nerves, which lasts for a long period after the disappearance of rash and blisters of shingles.

 

• Fibromyalgia

It is a disorder characterized by the spreading of musculoskeletal pain.

Fibromyalgia is associated with fatigue, problems with sleeping, memory, and mood.

• Partial onset seizures

Partial onset seizures are characterized by a change in emotions and feelings, but no loss of consciousness.

• Neuropathic pain with spinal cord injury

Pain associated with spinal cord injury is common, severe, and causes reduced quality of life.

Lyrica is a very effective drug that can be used in the above medical conditions.

How Lyrica is used?

Lyrica is available in many dosage forms with many concentrations.

Capsules, tablets, oral solutions, and many others.

Concentrations range from 20 to 330 mg.

Lyrica dosage is based on the medical condition and the dosage form used in addition to other factors related to the patient.

• Diabetic peripheral neuropathic pain and postherpetic neuralgia Lyrica dosage are similar as the following:

Regular-release capsules:

• 50 mg every 8 hours
• Maintenance dose: the dose can be increased to 100 mg every 8 hours through 1 week
• Maximum dose: 300 mg a day

Extended-release tablets:

• 165 mg a day
• Maintenance dose: the dose can be increased to 330 mg a day through 1 week
• Maximum dose: 330 mg a day

In patients with postherpetic neuralgia, no sufficient pain relief may last till after 4 weeks of treatment, in this case, the dose may be increased to 660 mg a day.

• Fibromyalgia and neuropathic pain with spinal cord injury are also similar as the following:

The regular-release capsules and oral solutions are the only dosage forms used.

• 75 mg every 12 hours
• Maintenance dose: the dose may be increased to 150 mg every 12 hours through 1 week
• Maximum dose: 300 – 400 mg a day
• If the pain relief is not sufficient after 3 weeks in patients with neuropathic pain with spinal cord injury, the dose may be increased to 600 mg a day divided every 12 hours if tolerated
• If the dose exceeded 450 mg a day dose-dependent adverse reactions occur
• Partial onset seizures

The regular-release capsules and oral solutions are the only dosage forms used.

Lyrica is used only as adjunctive therapy in partial-onset seizures, not as a drug of choice.

• Lyrica dosage starts with 150 mg a day divided every 8 – 12 hours
• Maintenance dose: the dose may be increased to 600 mg a day if tolerated

Lyrica dosage modifications:

Renal impairment: dose adjustment is needed; the doctor will adjust your dose if you suffer from renal impairment

Elderly patients may also need Lyrica dosage adjustment as they may have decreased renal function.

Hepatic impairment: No dose adjustment is needed.

Pediatric population: the safety and efficacy of Lyrica are not established in children younger than 12 years old.

What are the adverse effects caused by Lyrica?

Lyrica dosage is one of the most important factors affecting the adverse effects the patient suffers from.

Common adverse effects

• Dizziness
• Somnolence (sleepiness)
• Peripheral edema (swelling of the limbs)
• Ataxia (problems with coordination, balance, and speech)
• Fatigue
• Xerostomia (dry mouth)
• Weight gain
• Tremors
• Blurred vision
• Diplopia (double vision)

Less common adverse effects

• Vertigo (spinning sensation)
• Headache
• Balance problems
• Constipation or diarrhea
• Nausea
• Swelling of joints
• Nasopharyngitis (inflamed pharynx and nasal cavities)
• Increased liver enzymes
• Weakness and lack of energy
• Edema (swelling caused by trapped fluid in the tissues of the body) especially swelling of the face
• Hypotension (low blood pressure)
• Neuropathy (damage of one or more than one nerve)
• Pain
• Disorientation (altered mental status)
• Accidental injury
• Abnormal thoughts
• Confusion
• Amnesia (memory loss)

Regular Lyrica dosage is the average recommended dosage by the doctors for each medical condition, however, the dosage for any drug is determined based on many factors, type of medical condition, the severity of it, age of the patient, and others.

Lyrica tablets

Lyrica pregabalin

Lyrica capsules

 

Lyrica pregabalin

• Lyrica is a brand name of an active ingredient called pregabalin.
• Lyrica pregabalin is one of the most common medications in treatment seizures so it is known as an anticonvulsant medication.
• Also due to anti-anxiety effect, known as anxiolytic.

What are Lyrica pregabalin indications?

Due to its pharmacological activity, there are many indications:

• Certain types of seizures (anticonvulsant).
• Neuropathic pain: one of the diabetic complications causing severe nerve pain.
• Spinal cord injury associated with neuropathic pain.
• Postherpetic neuralgia: post herpes zoster infection.
• Fibromyalgia: as an alternative agent for a patient who does not respond or tolerate preferred agents.
• Generalized anxiety disorder.

What are the adverse effects of Lyrica pregabalin?

Lyrica pregabalin adverse effects:

 

• Blurred vision.
• Chest pain.
• Hypertension or hypotension.
• Contact dermatitis.
• Decreased libido.
• Abdominal pain.
• Weight gain.
• Dry mouth.

Most serious adverse effects, need to call your doctor immediately and stop medication:

• Severe allergic reaction.
• Severe dizziness.
• Trouble breathing.
• Suicidal attempt.
• Mental problems.
• Unusual change in your mood.

Lyrica pregabalin warnings and precautions:

Warnings and precautions of Lyrica pregabalin:

• Hypersensitivity: allergic reaction to Lyrica pregabalin, including skin redness, rash, dyspnea, and wheezing.
• Respiratory depression: which is a serious life-threatening condition. This risk increases with chronic obstructive pulmonary disease and in the elderly.
• Cardiovascular disease: Use with caution in heart failure patients.
• Renal impairment: use with caution and dosage adjustment is required.
• Peripheral edema: common adverse effect, so use with cautions in a patient with heart failure, and concomitant use of medications causing weight gain or peripheral edema.

Lyrica pregabalin and other medications interactions:

Revise all your medications before starting Lyrica pregabalin with your doctor.

Many drug-drug interactions may occur, so a dose adjustment may require.

Examples of these interactions:

Medications avoid concomitant use of pregabalin:

Medications decrease the effect of pregabalin:

Medications increase effects of pregabalin:

 

• Kava-kava.
• Magnesium sulfate.

Lyrica pregabalin may increase the effect of the following medications:

 

• CND depressants.
• Oxybate salt products.

Before starting Lyrica pregabalin:

You need to tell your doctor if you have one of the following medical conditions before starting Lyrica pregabalin:

• Heart problem: especially heart failure.
• Bleeding disorders: like thrombocytopenia (low platelets level).
• Lung disease: like a chronic obstructive pulmonary disease.
• Suicidal thoughts.
• Renal impairment.
• Drugs or alcohol abuse.
• Severe allergic and hypersensitivity reactions.

Things should be avoided during treatment with Lyrica pregabalin:

• Avoid driving.
• Avoid operate machinery.
• Avoid drinking alcohol.
• Avoid stopping Lyrica suddenly.
• Avoiding the use if you had a previous allergy history.

Special populations and use of Lyrica pregabalin:

There are many concerns of using Lyrica pregabalin in certain populations:

• Elderly: Lyrica should be used with caution in the elderly and dosage adjustment is required, so starting with the lowest dose is mandatory.
• Pediatric: Lyrica not approved in pediatric at age below 18.
• Pregnant: use of Lyrica in some cases may be necessary to control seizures, your doctor will help you to make a decision.
• Breast-feeding: it is not recommended to use Lyrica in breastfeeding.
• Renal impairment: use of Lyrica in renal impairment required specific dose adjustment according to the degree of impairment.
• Cardiac patients: use with caution especially with a congestive heart patient.

Lyrica pregabalin dosage and strengths:

Lyrica is available in many forms:

 

• Oral solutions.

Many strengths are available:

• Capsules: there are capsules contains 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, and 300mg.
• Oral solutions: 20mg/ml.
• Tablets: extended-release tablets 24 hour 82.5mg, 165mg, 330mg.

How to use Lyrica pregabalin?

• Take Lyrica by your mouth as your doctor’s instructions.
• You can use Lyrica with or without meals.
• You should swallow the whole tablet.
• You should not crush or chew tablets.
• You should take it at the same scheduled time.
• You should not stop the medication suddenly, need to tapper the dose under the supervision of your doctor.
• You should avoid drinking alcohol during use of Lyrica.
• You should store away from heat and light.
• If you missed dose, you should take it immediately. Only skipped if it is a time of the scheduled dose.

Lyrica pregabalin overdose:

Overdosing of Lyrica may cause by:

• Ingestion of too much dose.
• Concomitant use of medications increases the effects of Lyrica and may cause toxicity.

Overdosing signs and symptoms:

 

• Reduced consciousness.
• Trouble breathing.
• Heart block.

Call your doctor immediately and visit the emergency department of the nearest hospital.

Overdosing management:

Under the supervision of healthcare provider in hospital:

• induce emesis and gastric lavage.
• Maintain the airway.
• Monitoring vital signs.
• Lyrica may be removed by hemodialysis.
• There is no antidote for Lyrica.

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Lyrica tablets

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Lyrica V Gabapentin

Lyrica V gabapentin belongs to the same group of drugs called gabapentinoids.

They are both drugs used for treating neuropathic pain, and both of them have separated other uses.

Neuropathic pain happens as a result of damage occurring to the nervous system that causes the nerves to send incorrect messages causing different types of pain.

People describe the pain by the following words:

• tight
• shooting
• electric
• tingling
• burning
• piercing
• freezing
• stabbing

Lyrica V Gabapentin is also an antiepileptic drug used in controlling partial seizures in combination with other drugs.

Lyrica can also be used in:

• Fibromyalgia
• Off-label uses like generalized anxiety disorder, social anxiety disorder, bipolar disorder, insomnia (type of sleeping problems), and chronic pain conditions.

 

 

Gabapentin can also be used in:

• Amyotrophic lateral sclerosis (disease that affects nerve cells in the brain and the spinal cord)
• Off-label uses like restless leg syndrome, cocaine withdrawal, Insomnia, diabetic neuropathy, tremors in multiple sclerosis, and cancer-related hot flashes

How do they both work?

Lyrica V Gabapentin work by affecting the messages responsible for pain, reducing their effect on the nerve, and reducing pain.

How should I take them?

Lyrica V Gabapentin is available in oral forms only.

Capsules, extended-release tablets, and oral solutions

If you are taking the extended-release tablets, take them without chewing, crushing, or breaking

You should also take it at the same time every day to keep a constant level of the drug in the blood.

If you are taking the oral solution, you have to take it with a measuring syringe or special measuring device, don’t take it with household spoons, or else the dose will not be accurate

Lyrica V Gabapentin is usually taken two or three times daily

The doctor usually describes the lowest dose first, then increases it when needed till reaches the lowest effective dose.

Food doesn’t affect the absorption and bioavailability of the drugs.

If you missed a dose, take it as soon as you remember, if it is the time for the next dose, don’t double the dose, or else you may suffer from overdose symptoms.

If you overdosed on any of the two drugs, you should seek medical attention immediately.

Side effects:

There are common side effects between Lyrica and gabapentin

• Drowsiness
• Dizziness
• Tiredness
• Mood changes
• Edema in the limbs (swelling of them)

But as Lyrica is being absorbed more quickly, it causes fewer side effects.

Different side effects are:

Lyrica	Gabapentin
Dry mouth Constipation Breast enlargement Weight gain especially if you have diabetes	Speaking difficulties Fever Increased chance to get infected with viral infections Uncontrolled eye movements Fast uncontrollable movements (jerky movements)

 

 

 

Absorption:

Lyrica is absorbed more rapidly than gabapentin.

The peak concentration of Lyrica happens within 1 hour, while that of Gabapentin happens within 3-4 hours.

Potency:

Lyrica is a more potent antiepileptic drug resulting in the reduction of the frequency of seizures.

It is also more effective in controlling neuropathic pain caused by any of the mentioned conditions.

Both Lyrica V Gabapentin should not be stopped suddenly, the dose should be decreased gradually or else they may cause serious withdrawal symptoms.

Withdrawal symptoms of Gabapentin:

• Drowsiness
• Inability to control muscle movements
• Fatigue
• Nausea
• Vomiting
• Dizziness
• Anxiety
• Insomnia
• Sweating

Withdrawal symptoms of Lyrica:

• Headache
• Nausea
• Diarrhea
• Sleeping problems
• Sweating
• Anxiety

If you experience any of the above symptoms, you should consult with your doctor as soon as possible.

Lyrica V Gabapentin has similar interactions except that Gabapentin interacts also with NSAIDs (Non-steroidal anti-inflammatory drugs) such as ibuprofen, naproxen, and diclofenac.

Lyrica serious drug-drug interactions,

these drugs should not be used with Lyrica and you have to use an alternative drug.

• benazepril
• captopril
• enalapril
• everolimus
• fosinopril
• imidapril
• lisinopril
• metoclopramide intranasal
• moexipril
• perindopril
• quinapril
• ramipril
• sirolimus
• temsirolimus
• trandolapril

Gabapentin has similar serious interactions with some drugs.

• metoclopramide intranasal
• valerian

There are other lists for both drugs that need close monitoring when concomitantly used, always inform your physician about the drugs taken before taking either one of them.

Pregnancy and lactation:

Both Lyrica and Gabapentin should not be used in pregnant and breastfeeding women under normal conditions.

For Lyrica, there are not enough studies on pregnant women, so it should only be used if the benefits outweigh the risks and under close monitoring of the physician.

For Gabapentin, animal studies have given evidence of toxicity during the development of the fetus (abnormalities in the skeleton and increased mortality), it also should not be used except if the benefits way outweigh the risks.

Both of them have been detected in the mother’s milk, that’s why you should consult with your midwife about alternative feeding options, or with your doctor about alternative drugs.

Lyrica has been found to overweigh the effectiveness and potency of Gabapentin, fewer and less severe side effects, faster onset of action, and less needed dose.

Make sure to buy the drug of choice from a trusted source, such as pharmastores.

 

Difference between gabapentin and pregabalin

Pregabalin Overdose

 

Pregabalin half-life