How does pregabalin work
How does pregabalin work?
Pregabaline is a famous drug to treat neuropathic pain but how does pregabalin work? And what are the other indications of pregabalin?
Pregabalin approved by the FDA for the treatment of fibromyalgia, neuropathic pain and as add-on therapy for partial-onset seizures in adults with epilepsy
There are other Off-label uses that are not approved by FDA include social anxiety disorder, generalized anxiety disorder, chronic pain conditions, insomnia, and bipolar disorder.
This article will highlight how does pregabalin work? how to take it? adverse event profile, monitoring parameters, contraindication, and toxicity.
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How does pregabalin work?
Pregabalin resembles the structure of the inhibitory neurotransmitter gamma-aminobutyric acid GABA. It has lipophilic properties to enhance the crossing of it to the blood-brain barrier. However, pregabalin indirectly binds to GABA receptors results in decreasing the influx of calcium into neurons and reduces the release of excitatory neurotransmitters.
This is why pregabalin is used as an anticonvulsant and analgesic.
How to take pregabalin?
Pregabalin is available in capsules or oral solution and administered orally. Following oral administration, pregabalin reaches max concentration in the blood within 1.5 hours and achieves a complete action within 24 to 48 hours.
The absorption of pregabalin from the stomach is independent of the dose. Pregabalin can cross the blood-brain barrier. Humans cannot significantly metabolize pregabalin. It eliminates unchanged by renal excretion. In patients with normal renal function, the elimination takes 6.3 hours.
Dosages up to 600 mg/day did not provide additional benefit and were not well-tolerated due to several side effects.
Don’t stop pregabalin suddenly but taper the dose gradually over 1 week to avoid withdrawal symptoms or exacerbation of seizures.
How much do you need from pregabalin?
Diabetic Peripheral Neuropathy:
The therapeutic dose is 300 mg/day. The start with 50 mg three times per day. Increase The dose up to 300 mg/day within one week of treatment.
Postherpetic Neuralgia:
The dose is 150 mg to 300 mg per day, and can be taken twice or three times daily. Start with a dose of 75 mg two times per day or 50 mg three times per day.
Increase the dose up to 300 mg per day within one week of treatment. If no optimal pain control within 2 to 4 weeks of treatment with 300 mg per day, increase the dose to 600 mg per day, divided into twice per day or three times per dosing.
Spinal Cord Injury:
The dose ranges from 150 mg to 600 mg per day. start with a dose of 75 mg twice per day. Increase the dose to 150 mg twice per day within one week of treatment.
The dose may be increased up to 300 mg twice per day with suboptimal pain control following 2 to 3 weeks of treatment with 150 mg twice a day. In spinal cord injury, the improvement can be seen within one week after initiating treatment. However, it is recommended to try the medication for 4 to 6 weeks.
Adjunctive Therapy with Partial Onset Seizures:
The dose is 150 mg to 600 mg per day, divided into twice per day or three times per dosing. Start the dose with no greater than 150 mg per day and increase to a maximum of 600 mg per day.
Management of Fibromyalgia:
The therapeutic dose is 300 mg to 450 mg per day. Start with a dose of 150 mg/day divided into twice per day dosing. Increase The dose to 300 mg per day within one week of treatment. If no optimal pain control on 300 mg per day may be further increased to 450 mg per day, divided into twice per day dosing.
Dosing Modifications:
Pregabalin is eliminated by the kidney. Dose adjustment is required in impaired renal function. Patients with hepatic impairment do not require dosing modifications.
Adverse events
Most of the adverse effects related to pregabalin were mild to moderate intensity.
The severity of adverse events is not dose-dependent and occurred within the first two weeks of initiating treatment.
Somnolence and dizziness are the most common adverse events that have been reported with the use of pregabalin, and they are the most frequent cause of treatment discontinuation, and of course, this is related to how does pregabalin works.
In premarketing controlled trials, The most common adverse reactions reported which occurred in greater than or equal to 5% of patients and twice the rate reported by patients receiving placebo were: dizziness, somnolence, blurred vision, dry mouth, difficulty with concentration/attention, edema, and weight gain.
Weight gain occurred in up to 14% of patients receiving 600 mg per day and was dose-dependent.
Withdrawal symptoms can occur after rapid discontinuation of pregabalin including hyperhidrosis, insomnia, nausea, nervousness, irritability, headache, anxiety, and diarrhea.
Contraindications
Pregabalin is contraindicated in case of hypersensitivity to pregabalin. There are no enough studies on pregnant women. But there are some reported cases that Pregabalin may cause fetal harm, so use caution in case if you are pregnant.
Pregabalin is not recommended in breastfeeding as it can be detected in the milk of lactating women
Monitor patients for symptoms of new or worsening depression, suicidal behavior or ideation, and other changes in behavior or mood, as pregabalin is like the other antiepileptic drugs can increase the risk of suicidal thoughts or behavior.
Pregabalin and Alcohol
Pregabalin and Alcohol
Pregabalin is an anti-epileptic and anticonvulsant drug. It works to control seizures by slowing down impulses in the brain. Also, Pregabalin affects chemicals in the brain that send pain signals across the nerves.
Pregabalin is used in the treatment of fibromyalgia, diabetic neuropathy, herpes zoster, or spinal cord injury.
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Pregabalin and Alcohol:
There are two main questions to ask about while studying these two words Pregabalin and alcohol:
First: Can you drink alcohol while using Pregabalin?
Second: Does Pregabalin has a role in the treatment of alcohol dependence, alcohol withdrawal, or alcoholism?
1- Can you drink alcohol while using Pregabalin?
Drug Interaction Classification:
There are four classifications which are only a guideline for the determination of how far the risk of drug interaction with other factors:
- Major: the risk of interaction is bigger than the benefit, so, you should avoid combinations.
- Moderate: it is better to avoid combinations or it may be used only under specific circumstances.
- Minor: minimal clinically significant.
- Unknown: no available information about the interaction.
According to the previous classification, we can say that Pregabalin and Alcohol interaction is considered as a moderately clinically significant drug interaction.
So, patients are recommended to avoid alcohol generally while using Pregabalin or they may limit consumption of alcohol.
Why alcohol should be avoided or limited while using Pregabalin:
At the same time that Pregabalin acts on the central nervous system to manage pain or control seizures and convulsions by affecting nerves or affecting the release of other chemical substances in the brain, Alcohol also may potentiate some of the pharmacological effects of CNS active agents; using them simultaneously may lead to:
- excessive central nervous system depression
- excessive sleepiness or even coma
- confusion of thinking, judgment, or other psychomotor skills
- Increased drowsiness and dizziness
- Concentration issues
- It may depress the central nervous system causing breath issues leading to a potentially life-threatening condition
- Reduction of alertness
- Swelling of throat, lips, or tongue
- Itching
- Hives
How to cope with the side effects of Pregabalin?
You can avoid some factors while using Pregabalin to minimize the possible side effects that would happen:
- Headache: drink plenty of fluids, take a rest, don’t drink too much alcohol, you may ask your health provider for a suitable analgesic.
- Mood alteration: talk to your health provider as you may need to switch to a different medicine
- Feeling sick: take Pregabalin with or after a meal or snacks
- Blurred vision: during that avoid driving or using sharp or heavy tools
- Weight gain: Pregabalin increases the feeling of hunger so try to eat well healthy food, avoid too many snacks especially with meals, don’t take food with high calories. Between meals, you can eat fruits when you feel hungry. Regular sports will also help to keep your weight stable.
- For men, erection problems may occur: speak to your health care provider as he may recommend a different medicine
- Memory problems: speak to your health care provider as he may recommend a different medicine
- Swollen hands, arms, legs, or feet: avoid standing for a long time, try to sit with your feet up on a chair or bed, exercise may be useful for swollen arms.
- Feeling tired or sleepy: speak to your health care provider as he may recommend reducing the Pregabalin dose or increase it more slowly or switch to a different medicine.
2- Does Pregabalin has a role in the treatment of alcohol dependence?
Alcohol Dependence:
Alcohol dependence represents a severe pathological disorder in which patients are subjected to a high risk of morbidity or mortality. Although limited pharmacological agents are there to treat this disorder, studies are continued promising for new therapies.
- Pregabalin’s clinical use in alcoholic patients shows promise as a good treatment for the management of alcohol relapse.
- During the study made for detoxified alcohol-dependent patients receiving Pregabalin, 50%of patients remained completely alcohol-free, a significant improvement of withdrawal symptoms and alcohol craving was noticed.
- A greater beneficial effect was found in patients with comorbid conditions such as alcoholism and anxiety disorders.
- Pregabalin use appears to be safe and well-tolerated.
- Since seizures are a potential serious manifestation of alcohol withdrawal, Pregabalin’s anticonvulsant effect may be beneficial in this case.
Cautions for using Pregabalin with other medicines:
- Pregabalin can be safely used with other medicines, however, you should tell your doctor before starting Pregabalin if you take certain medicines such as strong pain killers like morphine or other medicines that make you feel dizzy or sleepy.
- There is no evidence for any problems resulting from mixing Pregabalin with supplements, vitamins, or herbal remedies.
Does Pregabalin affect fertility?
There is no evidence that Pregabalin reduces fertility in either men or women. However, if you are trying to get pregnant talk to your doctor before taking Pregabalin.
Does Pregabalin affect contraception?
Any type of contraception (including contraceptive pills and emergency contraception) is safe while using Pregabalin, it doesn’t stop contraception work.
Is Pregabalin a pain killer
Is Pregabalin a pain killer?
Pregabalin is used to treat some kinds of pain that are persisting and don’t easily go away.
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It is especially used for neuropathic pain that can occur to patients suffering from diabetes (pain that happens if the nervous system is damaged or diseased).
30% of neuropathic pain happens because of diabetes, but it can also happen due to drinking alcohol and the infection with herpes zoster.
But Pregabalin can also overcome these conditions; it can treat the pain happening after the infection with herpes zoster.
It is also the first approved therapy for fibromyalgia (a disorder characterized by pain accompanied by fatigue, sleep, memory problems, and mood changes).
Pregabalin is used in managing pain coming after a spinal cord injury.
It is also used off-label in chronic pain conditions.
So, Is Pregabalin a pain killer?
Well, after all these indications, we have to say yes, Pregabalin is a very good pain killer.
How does Pregabalin manage the pain?
It controls the chemicals that cause the brain to send pain signals through the nervous system.
It reduces them resulting in reducing the pain.
Dosage and administration:
Is Pregabalin a pain killer?
Well, Pregabalin is available in many dosage forms, capsules, extended-release tablets, and oral solution.
The doses should be taken exactly as the doctor said.
If you are taking the oral solution, take it with a special measuring device (dosing syringe) or with a medical spoon.
Don’t take it with a household spoon, to make sure you are taking the correct dose.
If you are taking the extended-release tablets, take them at the same time every day.
Swallow the whole tablet without crushing, chewing, or breaking the tablet.
The dose is determined according to the severity of the medical condition, age, and weight of the patient.
Contact your doctor if you are not improving, or if the symptoms are getting worse.
If you missed a dose, take it as soon as possible, but if it is the time for the next dose, skip it and don’t double the dose.
What if you overdosed?
Go to the nearest hospital or call an ambulance immediately to prevent suffering from any serious side effects.
Is Pregabalin a pain killer?
Yes, but before using it, make sure to understand the following precautions.
Warnings:
- Pregabalin can cause an allergic reaction which may be severe, if you suffered from any hives, breathing problems, swelling in the face or lips, or even blisters on your skin, ask for emergent medical help.
- Some patients using Pregabalin may experience suicidal thoughts or behaviors; you have to tell your doctor immediately and stay alert to these changes in your mood.
- Notice any weight gain or swelling of limbs especially if you are having diabetes or heart problems.
- Pregabalin is not a drug to be stopped suddenly, the dose should be decreased gradually or else you will suffer from withdrawal symptoms.
Withdrawal symptoms:
- Seizures
- Dizziness
- Diarrhea
- Nausea
- Headache
- Vomiting
- Agitation
- Insomnia (sleeping problem)
- Tingling
- Nightmares
Is Pregabalin a pain killer?
Before taking this drug, tell your doctor about the following conditions:
- Lung diseases
- Mood disorders
- Depression or suicidal thoughts
- Heart problems
- Bleeding disorders especially congestive heart failure (a chronic condition that affects how the heart pump blood)
- Kidney diseases
- Diabetes unless it is used because of the neuropathic pain caused by diabetes
- Any sort of addiction (alcohol or drug)
- Angioedema (swelling in the lower layer of skin and tissue, it may be in the face, tongue, larynx, or other parts of the body), happens as a result of allergic reactions
Is Pregabalin a pain killer?
Yes, but take care of its side effects.
Side effects that occur in more than 10% of patients:
- Dizziness
- Somnolence
- Peripheral edema (swelling in the limbs)
- Ataxia (lack of control of the muscles)
- Fatigue
- Xerostomia (reduced saliva causing dry mouth)
- Weight gain
- Tremors
- Blurred vision
- Diplopia (Double vision)
Side effects that occur in less than 10 % of patients:
- Vertigo (Weird feeling of moving objects while they are not)
- Headache
- Constipation
- Nausea
- Limbs swelling
- Amnesia (memory problems)
- Confusion
This is not a full list of side effects; always talk to your doctor about the unusual effects that you are experiencing.
Interactions:
Is Pregabalin a pain killer?
Yes, but take care of the drug and food interactions before taking it.
Serious drug interactions use an alternative:
- benazepril
- captopril
- enalapril
- everolimus
- fosinopril
- imidapril
- lisinopril
- metoclopramide intranasal
- moexipril
- perindopril
- quinapril
- ramipril
- sirolimus
- temsirolimus
- trandolapril
There are lists of drugs that cause unwantable interactions, and need close monitoring, discuss all the drugs you are taken before taking any other drug.
Is Pregabalin a pain killer?
Yes, a very effective, potent, with very few side effects.
It also has a rapid onset and a long duration of action.
If you are suffering from any kind of pain, make sure to talk to your doctor about Pregabalin.
How long does Pregabalin take to work
How long does Pregabalin take to work?
Before we talk about the time interval required for the Patient to feel better by using Pregabalin, how long does Pregabalin take to work, and to what extent Pregabalin is the drug of the choice, it’s important to know that the effect of Pregabalin differs from one patient to another, from case to another, and from dose to dose?
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Pregabalin treating different conditions:
- In fact, the way Pregabalin work for pain management, for example, is that it blocks the effect of damaged nerves responsible for sending false messages to the brain causing pain. Pregabalin changes the way these nerves work or it may calm overactive nerves which means it is a good helper with other analgesics to reduce pain by a different mechanism and shorter time to feel better.
- In patients with neuropathic pain (diabetic neuropathy or postherpetic neuralgia) time to onset of pregabalin analgesic effect under fixed-dose recorded a marked rapid onset of action.
- When you hear about the patients’ (suffering from anxiety disorders) reviews about this medicine, you find out that about 83 % of them were satisfied by its positive rapid action helping them cool down quickly. That is due to its capability to prevent the release of chemicals in the brain that makes you feel anxious.
The righter way of use, the better it works:
To get the best benefit and the fastest progress leading to a shorter time for Pregabalin to work, use Pregabalin in the right way:
- It is recommended to take Pregabalin exactly as the doctor prescribed without changing any of the instructions he said.
- Take Pregabalin at the same time every day.
- Take Pregabalin with or without food but it is preferred to take the evening dose after a good meal.
- Avoid missing pregabalin dose (if so take it once you remember that, however, avoid taking two doses at the same time).
- Avoid stopping it suddenly as it may lead to worsening the condition.
- Of course, do not stop it without talking to your medical health provider.
Back to the main question:
How long does Pregabalin take to work?
After following the previous instructions and using Pregabalin in the right way, considering the different conditions and doses for different patients:
- Some patients may experience pain decrease in the first week of treatment or even in the first few days.
- Other patients may start to feel better in the second week.
- For others, it may take a longer time according to the severity of the case, the dose of Pregabalin, and other factors. if so, you may ask your doctor for help by adjusting the dose or give you other recommendations according to the condition.
Pregabalin could be taken for a long period if it helps, you may need to gradually decrease the dose after a while to check if the pain still exists or you became much better now, but don’t stop it suddenly, you should refer to your doctor first.
The relation between Pregabalin Rapid Absorption and how long does Pregabalin take to work:
Pregabalin is rapidly absorbed after oral administration. In comparison to Gabapentin’s bioavailability (from 30 – 60%), the oral bioavailability of Pregabalin is over 90% whatever the dose received. Both Gabapentinoids (Pregabalin & Gabapentin) are absorbed across the gastrointestinal tract. The rate of Pregabalin absorption is threefold higher than that of Gabapentin, that’s why Pregabalin achieves faster peak blood concentration compared with Gabapentin
How long does Pregabalin stay in your body?
Depending on various personal factors, it stays about 33 hours higher or lower according to the patient’s age, food, and other medications.
Factors affecting how long it stays in your body:
- Age
- Dosage
- Kidney function
- Hydration
- Body mass
- PH of urine
- Duration of taking the medication
Pregabalin oral clearance is likely to decrease with increasing age, therefore, for older patients dose reduction should be considered.
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How long does Pregabalin stay in Blood, Urine, and Hair?
- In blood, it stays about 2 days after your last dose.
- In urine, it stays a litter bit longer than in blood (few days depending on the dosage).
- In hair, it stays much longer than in blood and urine, may be up to 3 months.
Too Much Pregabalin:
If you think you have taken too much of Pregabalin or you experience one or more of the following symptoms, call your health care provider at once:
- Drowsiness
- Dizziness
- Headache
- Nervousness
- Lack of control of the body movements
- Tremors
- Amnesia
Clinical Monitoring:
– To make sure that you stay safe while taking Pregabalin your doctor may ask you to do certain blood tests to check if you need to take a lower dose according to how well your kidneys are working.
– Changes in mood or behavior should be monitored as this drug may cause behavioral problems.
Pregabalin for depression
Pregabalin for depression
Depression is a mood disorder that causes the person to be sad and have lost interest in life and anything.
It affects how the patient’s feelings, behaviors, and thinkings.
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It can be severe that may lead the patient to feel that life doesn’t worth to be lived.
Depression is usually associated with signs and symptoms of anxiety.
So, before talking about Pregabalin for depression, let’s understand first the relation between depression and anxiety.
The U.S (United States) National Comorbidity Study declared that 58% of patients diagnosed with major depressive disorder we also diagnosed with comorbid anxiety disorder.
As reported by Zinbarg et al., in 1994. Patients suffering from depression can show strong signs of agitation and anxiety.
Those patients suffering from anxiety and major depression are identified to have anxious depression.
These kinds of depressed patients meet the diagnosis of a comorbid anxiety disorder combined with axis II clusters (dramatic, very emotional, or surprising thinking or behavior).
So when these patients start the treatment,
the doctor should take into consideration treating the anxiety symptoms as well as treating the depression.
It is highly important to take care of the anxiety symptoms to prevent the illness to be converted to a chronic one.
Patients with depression and comorbid anxiety symptoms suffer from severe depression and suicidal thoughts with a higher risk of performing suicide.
Pregabalin could become an excellent added drug to the antidepressant in patients suffering from depression associated with anxiety and agitation, which may also replace benzodiazepines during the first period of treatment as it outweighs them in the onset of action, which is a very big benefit for the patients.
Few studies had already shown the benefits of adding Pregabalin to the therapy regimen of patients suffering from depression not completely responding to antidepressant medications, or in elder patients suffering from a comorbid generalized anxiety disorder.
Pregabalin has already shown a very good anti-anxiety effect in patients with generalized anxiety disorder.
It is also very effective in the prevention of relapse of patients suffering from a generalized anxiety disorder.
Pregabalin for depression is a well-tolerated drug with fewer side effects and less risk for dependence.
Although new data have shown susceptibility of abuse when using Pregabalin for depression, it possesses comparable effectiveness with benzodiazepines, with no major interactions.
In treating depression and anxiety, the often-used were a combination of antidepressant drugs, which showed 2-4 weeks onset of action, which may cause complete disturbance for the patient and may cause him to stop the therapy.
Pregabalin for depression has proved to work from the first week by reducing the symptoms of anxiety and depression.
Anxiety symptoms were measured by the HAMA scale (Hamilton Anxiety Rating Scale), and the depressive symptoms were measured by the HAMD (Hamilton Depression Rating Scale), and those scales were found to decrease starting the treatment and throughout the therapy period.
So, what is Pregabalin?
Pregabalin for depression is an anti-epileptic drug.
It slows down the impulses send by the brain to cause seizures, and also affects the chemicals that send signs of pain across the nervous system.
Uses and indications:
Pregabalin is not just used for depression, it has many other uses.
- Peripheral neuropathic pain associated with diabetes
- Neuralgia happening after the infection with the herpes zoster virus
- The pain caused by fibromyalgia, the first drug approved for this case
- Partial-onset seizures
- Neuropathic pain happening after spinal cord injury
- used off-label in generalized anxiety disorder, bipolar disorder, insomnia (sleeping disorder), social disorders, and conditions of chronic pain
N.B. Neuropathic pain is pain happening from what is supposed to not be painful due to damage or disease affecting the nervous system.
Dosing and administration:
Pregabalin for depression is available in many dosage forms but all of them are orally taken forms, no injectable or rectal ones.
The dose should be taken exactly as prescribed by the doctor.
The dose depends on the age and weight of the patient and also on the medical condition.
Interactions:
As we clarified before, there are no contraindicated drugs to be concomitantly used with Pregabalin for depression, but there are drugs that may cause serious interactions that the patient should use an alternative drug in this case.
- benazepril
- captopril
- enalapril
- everolimus
- fosinopril
- imidapril
- lisinopril
- metoclopramide intranasal
- moexipril
- perindopril
- quinapril
- ramipril
- sirolimus
- temsirolimus
- trandolapril
Pregabalin should not be also used while consuming alcohol, as alcohol can increase the side effects of the nervous system, dizziness, drowsiness, and concentration problems.
Pregnancy and lactation:
Pregabalin for depression should only be given to pregnant women when there are no other alternatives, and when the benefits outweigh the risks.
Breastfeeding while on drug therapy with Pregabalin, tumorigenicity could happen (susceptibility for growing tumors either benign or malignant).
So breastfeeding is not recommended while using Pregabalin for depression.
This is not a full list of information about Pregabalin for depression; always talk to your doctor about the full information about any drug before taking it.
Does Pregabalin cause weight gain?
Does Pregabalin cause weight gain?
If you are asking “does pregabalin cause weight gain?”. The answer is yes.
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There are a lot of drugs that induce weight gain, weight gain is a very serious and annoying side effect. One of these drugs is pregabalin.
Weight gain can lead to stopping the therapy and exacerbating a lot of medical conditions, weight gain is a problem that can lead to glycemic control and increasing blood pressure or worsening lipid profile.
Patients can control weight gain by adhering to a suitable diet and exercise or even they can take drugs to control this problem.
This problem is common with most antipsychotics drugs like clozapine risperidone olanzapine and quetiapine, and also some antidepressant such as mirtazapine and amitriptyline, and this problem are not related to the disease severity but related to the drug itself.
The same phenomenon is related to some Antiepileptic drugs (AEDs) and mood stablilizers like carbamazepine, valproate, and gabapentin.
A meta-analysis (a study that analyses the results of independent studies of the same topic to determine overall trends) included 106 studies and 43,525 patients, that published in 2012 by the Current Medical Research and Opinion concluded that 70% of pregabalin users by a dose of 150 to 600 mg once daily maintained 7% of baseline weight.
1 in 6 patients gained more than 7% from baseline One in six patients gained ≥7% weight from baseline.
In pregabalin controlled clinical trials in adult patients which lasted for 14 weeks, a gain of 7% or more over baseline weight was observed in 9% of pregabalin-treated patients. Few patients treated with pregabalin (0.3%) could not complete the controlled trials due to weight gain.
pregabalin associated weight gain was related to dose and duration of exposure, increasing the dose increases the chances of weight gain as doses of 600 mg were associated with a higher percentage of weight gain but the percentage did not appear to be associated with baseline BMI, gender, or age.
Although weight gain related to pregabalin was not associated with clinically important changes in blood pressure in short-term use, the long-term cardiovascular effects of pregabalin-associated weight gain are not clear.
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Pregabaline and diabetes:
If you are a diabetic patient you should ask about does pregabalin cause weight gain?
Among diabetic patients, pregabalin-treated patients gained an average of 1.6 kg (range: -16 to 16 kg), In a study of 333 diabetic patients who received pregabalin for at least 2 years, the average weight gain was 5.2 kg.
While the effects of pregabalin-associated weight gain on glycemic control have not been systematically assessed, in controlled and longer-term clinical trials with diabetic patients, pregabalin treatment did not appear to be associated with loss of glycemic control.
Pregabaline and heart failure:
Pregabaline can cause peripheral oedema (swelling of limbs), so caution must be paid to the patient with heart failure and with patients using other drugs that cause peripheral oedema like thiazolidinedione antidiabetic drug (rosiglitazone, pioglitazone).
The incidence of peripheral oedema associated with pregabalin was 6% and only 0.5% stopped the medication and withdraw from controlled clinical trials.
There are a lot of studies that tried to relate between pregabalin and heart failure as pregabalin can cause fluid retention and weight gain which may be an overload to the heart, but none of them was able to confirm that pregabalin can cause heart failure or exacerbation to chronic heart failure.
This may answer the patient who always asking ‘Does pregabalin cause heart failure?’ ‘Does pregabalin cause weight gain?’.
There are a lot other common adverse events related to pregabalin such as:
Common adverse events:
- Sore throat.
- Increased appetite.
- Decrease in sexual interest, feeling of elation, confusion, disorientation, irritability.
- Disturbance in attention, clumsiness, memory impairment, loss of memory, tremor, difficulty with speaking, tingling feeling, numbness, sedation, lethargy, insomnia, fatigue, feeling abnormal.
- Blurred vision, double vision.
- Vertigo, problems with balance, fall.
- Dry mouth, vomiting, flatulence, constipation, nausea, swollen abdomen, diarrhoea.
- Difficulties with erection.
- Abnormal style of walking, Feeling drunk.
- Joint pain, pain in limb, muscle cramp, back pain.
Rare adverse event:
- Swinging vision, vision loss, abnormal sense of smell, visual brightness, altered perception of depth.
- Dilated pupils, cross eyes.
- Cold sweat, tightness of the throat, swollen tongue.
- Inflammation of the pancreas.
- Difficulty in swallowing.
- Slow or reduced movement of the body.
- Difficulty with writing properly.
- Increased fluid in the abdomen.
- Fluid in the lungs.
- Changes in heart rhythm.
- Muscle damage.
- Abnormal breast growth, breast discharge, breast growth in males.
- Interrupted menstrual periods.
- Kidney failure, reduced urine volume, urinary retention.
- Decrease in white blood cell count.
- Inappropriate behaviour.
- Jaundice (yellowing of the skin and eyes).
Serious adverse events:
- life-threatening allergic reactions.
- Suicidal thoughts.
- Swelling of peripheral limbs.
- Serious problems with breathing.
We hope that we explain if “Does Pregabalin cause weight gain?” was useful to you. Rememberer always to ask your doctor or pharmacist before any medical decision.
Gabapentin V Pregabalin
Gabapentin V Pregabalin
A better drug with lower cost, it is also used in lower doses, yes, it is Gabapentin V Pregabalin but of course, Pregabalin has always won the competition.
| Thumbnail | Name | Categories | Date | Price | Buy |
|---|---|---|---|---|---|
| Lyrica pregabalin 150mg generic | Pain relief | 2020-07-01 06:22 | £25.00 – £133.00 | Add to cart This product has multiple variants. The options may be chosen on the product page £25.00 £93.00 £133.00 |
What is Gabapentin?
Gabapentin is an anticonvulsant drug that affects chemicals and nerves causing seizures and some types of pain.
It is used in combination with other drugs to treat partial seizures in adults and children older than 3 years old.
Gabapentin is also used for treating neuropathic pain (pain due to damaged or diseased nerve) caused by the herpes virus or herpes zoster (shingles) in adults.
Gabapentin V Pregabalin, so What is Pregabalin?
Pregabalin is also an anticonvulsant drug; it slows down the impulses causing seizures in the brain.
It also affects the chemicals that send signals of pain through the nervous system, so it is used to treat pain caused by fibromyalgia (condition distinguished by pain throw out the body, or neuropathic pain of diabetic patients, neuralgia caused by herpes zoster (severe pain due to damaged nerve), or that pain coming after spinal cord injury.
Pregabalin is used as adjunctive therapy in treating partial-onset seizures in adults and children older than 1 month old.
It also has off-label uses, generalized anxiety disorder, social anxiety disorder, bipolar disorder, insomnia, and chronic pain disorders like sciatica and others.
So both of them are used for peripheral neuropathic pain and post-herpetic neuralgia, but what are the differences of Gabapentin V Pregabalin?
Let’s take the point after the other.
-
Cost:
According to a hypothetical cohort of 1000 patients, Pregabalin was found to be much more cost-effective than gabapentin.
According to a retrospective cohort of palliative care outpatients at the University of Arkansas for medical sciences (UAMS) palliative care clinic (PCC), no significant difference was found in terms of effectiveness.
But there was a significant difference in the number of pills taken and the discontinuation of the drug as a result of side effects.
Gabapentin V Pregabalin showed an advantage over Pregabalin as the average number of pills needed for Pregabalin was 0.01, while gabapentin was 1.8.
Pregabalin also showed superiority in the number decreasing the dose due to adverse effects caused, as those treated with gabapentin were decreasing the dose more than Pregabalin.
Pregabalin was much more tolerated than gabapentin.
gabapantin v pregabalin
Gabapentin is more likely to cause speaking difficulties, fever, and increased susceptibility to viral infections, unusual eye movements, and jerky movements (fast uncontrollable movements with no purpose.
Pregabalin is more likely to cause dry mouth, constipation, edema (swelling), breast enlargement, and weight gain.
- Absorption:
Gabapentin V Pregabalin, Pregabalin also shows superiority in absorption, it is absorbed faster and works more quickly than gabapentin.
Pregabalin reaches the maximum concentration in the blood within an hour, whereas gabapentin takes about 3-4 hours.
-
Interactions:
Although Gabapentin V Pregabalin has similar interactions as they belong to the same class of medicine, gabapentin also interacts with NSAIDs (Non-steroidal Anti-inflammatory drugs) such as ibuprofen, naproxen, and diclofenac.
As Gabapentin V Pregabalin belongs to the same class of medicine, they have similarities between them.
- They work with the mechanism, which makes them having almost similar effectiveness.
- Both of them may cause abuse, that’s why they were declared from 1 April 2019 as a schedule 3 controlled drugs under the Misuse of Drugs Regulations 2001, and Class C of the Misuse of Drugs Act 1971.
- Similar side effects like dizziness, drowsiness, incoordination, memory problems, tremors, and blurred vision were caused by both drugs.
- Gabapentin V Pregabalin has shown withdrawal side effects on sudden stopping, both of them must be decreased gradually.
gabapantin v pregabalin
Abstract:
Gabapentin V Pregabalin has shown almost similar effectiveness, but Pregabalin outweighed gabapentin in a number of taken pills, cost-effectiveness, faster onset of action, tolerance, and fewer interactions.
- So if your doctor prescribed Pregabalin for your medical condition, make sure to inform your doctor about the following conditions before consuming the drug:
- Lung problems
- Mood changes like depression, or suicidal thoughts
- Heart problems
- Bleeding disorder
- Kidney problems
- diabetes, unless you are taking it for the neuropathic pain caused by diabetes
- Severe allergic reactions to Pregabalin or any other
- Pregabalin should not be used in patients younger than 18 years old for the treatment of pain caused by several reasons including fibromyalgia, diabetes, herpes zoster, or spinal cord injury
- It is not also approved for use by patients younger than 1-month-old for the treatment of seizures
- If you become pregnant, don’t start nor stop taking Pregabalin without the advice of your doctor, as seizure control during pregnancy is highly important
- Pregabalin may affect the fertility of men, as it can decrease the number of sperms
It also showed birth defects in the offsprings of males using Pregabalin as the animal studies showed
Always confirm with your health care provider the information you read on any medical article to make sure this information is convenient for your medical condition.
How long does it take for Pregabalin to work
How long does it take for Pregabalin to work?
Pregabalin, this relatively new drug first stated in 2004 with Pfizer on the regulatory status of it, then obtained approval from the FDA (Food and Drug Administration) for the treatment for neuropathic pain on the last day of 2004.
| Thumbnail | Name | Categories | Date | Price | Buy |
|---|---|---|---|---|---|
| Lyrica pregabalin 150mg generic | Pain relief | 2020-07-01 06:22 | £25.00 – £133.00 | Add to cart This product has multiple variants. The options may be chosen on the product page £25.00 £93.00 £133.00 |
In 2007, FDA approved Pregabalin as the first drug for the management of fibromyalgia.
In 2012, it approved Pregabalin for controlling the neuropathic pain (damage or disease affecting a part of the sensory nervous system called the somatosensory system which causes pain in the nerves) caused by spinal cord injury.
And the successes continue when the FDA approved Pregabalin extended-release tablets for neuropathic pain conditions in 2017.
Pregabalin is also used for postherpetic neuralgia (severe pain sensed as stabbing or burning sensation caused by the irritating or damaged nerve), and as adjunctive therapy in treating partial-onset seizures.
And if we are going to talk about the successes of Pregabalin, we have to talk about how long does it take for Pregabalin to work?
Pregabalin is a fast-acting drug with high absorption after oral administration.
How to use Pregabalin?
Before taking any medication, you have to read the medication guide carefully.
If you have any inquiries, consult with your health care professional.
This is an orally available drug only.
It is not available as neither injectable nor rectal forms.
The dosage is based on the age and weight of the patient, medical condition, kidney function, and response to treatment.
If you are using the oral solution, use a special measuring device or spoon, don’t use a household spoon as it may give an incorrect dose which affects the effect of the drug.
You should start the medication with a low dose, then the physician can increase the dose as needed till reaches the lowest effective dose.
The dose must be taken at the same times every day to ensure a constant level of Pregabalin to make sure that the patient takes the most benefit of it.
To take the best on the drug, you have to understand how the drug works and how long does it take for Pregabalin to work?
How does Pregabalin work?
Pregabalin works by slowing down the impulses of the brain causing seizures, that’s how it works as an anti-epileptic drug and as an adjunctive drug to treat partial-onset seizures in adults and children who are 1 month and older.
It also affects the chemicals that send signals for pain through the nervous system, that’s how it works to treat pain caused by fibromyalgia, or the neuropathic pain caused by diabetes, or neuralgia that happens after the infection with herpes zoster, or the pain produced after a spinal cord injury.
| Thumbnail | Name | Categories | Date | Price | Buy |
|---|---|---|---|---|---|
| Lyrica pregabalin 150mg generic | Pain relief | 2020-07-01 06:22 | £25.00 – £133.00 | Add to cart This product has multiple variants. The options may be chosen on the product page £25.00 £93.00 £133.00 |
How long does it take for Pregabalin to work?
Pregabalin is a fast-acting drug; the peak of concentration after oral administration happens after 1.5 hours, it has greater than 90% bioavailability (the percentage available to the intended destination) no matter what the dose is.
Pregabalin can be taken with food as food doesn’t affect the total absorption of Pregabalin.
However, it was found that food affects and decreases the concentration in the plasma by 25%-30%.
And also increases the time to reach the peak of the drug to 3 hours approximately.
How long does it take for Pregabalin to work
Contraindications:
Before taking Pregabalin, make sure to inform your doctor if you suffer from any of the following conditions,
- Lung problems
- Depression
- Suicidal thoughts
- Mood disorder
- Heart problems
- Bleeding disorder
- Kidney problems
- Diabetes, except you, are taking it to manage the neuropathic pain associated with diabetes
- Any sort of abuse either drug or alcohol abuse
- Severe allergic reactions
Pregabalin is not approved for:
- seizures in patients younger than 1-month-old
- pain caused by fibromyalgia, diabetes, herpes zoster, or spinal cord injury in patients younger than 18 years old
Interactions:
Before taking Pregabalin, you must make sure that you are not taking a drug or food that interacts with it.
Drugs causing serious interactions and you have to use an alternative:
- benazepril
- captopril
- enalapril
- everolimus
- fosinopril
- imidapril
- lisinopril
- metoclopramide intranasal
- moexipril
- perindopril
- quinapril
- ramipril
- sirolimus
- temsirolimus
- trandolapril
Several drugs need close monitoring while being used with Pregabalin, some of them are:
- alprazolam
- amitriptyline
- amobarbital
- belladonna and opium
- benzhydrocodone/acetaminophen
- buspirone
- butabarbital
- carbinoxamine
- cenobamate
- cetirizine
- chloral hydrate
- chlordiazepoxide
- chlorpheniramine
- citalopram
- codeine
- diazepam
- doxepin
- duloxetine
- escitalopram
- eszopiclone
- ethanol
- fentanyl
- midazolam
And many others always tell your doctor about the medications you are taking before taking a new one.
Pregabalin-Alcohol interactions:
Alcohol can increase the side effects of Pregabalin especially those affecting the nervous system, like dizziness, drowsiness, and concentration problems.
We must not also forget about the absorption effect caused by food, so it is preferable to take Pregabalin away from meals.
Pregabalin has many advantages including effectiveness and how long does it take for Pregabalin to work?
Don’t forget to buy Pregabalin from trusted sources such as pharma stores to make sure about the drug you are buying, and also to get the best offers.
Pregabalin 75mg
Pregabalin 75mg
Pregabalin 75mg is an antiepileptic drug, that is used to help control seizures (convulsions), It acts by slowing down the impulses in the brain that cause seizures.
| Thumbnail | Name | Categories | Date | Price | Buy |
|---|---|---|---|---|---|
| Lyrica pregabalin 150mg generic | Pain relief | 2020-07-01 06:22 | £25.00 – £133.00 | Add to cart This product has multiple variants. The options may be chosen on the product page £25.00 £93.00 £133.00 |
Pregabalin also affects chemicals in the brain that send pain signals across the central nervous system (CNS), but it will not cure epilepsy, it will only work to control seizures caused by it.
Pregabalin also is known for its good effect as an anticonvulsant and neuropathic pain agent.
Also, this medication is used to reduce pain caused by nerve damage due to diabetes or
shingles (herpes zoster), or a spinal cord injury.
It can be also used to treat fibromyalgia (muscle pain and stiffness).
Sometimes it is used “off-label” (not approved by FDA), to prevent migraine attacks. but your doctor can prescribe it to you if it seems to help.
Dosage Forms:
Pregabalin is available in many forms such as capsule, oral solution, or tablet (extended-release) with different available concentrations.
Proper Use
Do not take more of Pregabalin 75mg, and do not take it for a longer time than your doctor prescribed, to reduce the chance of side effects occurrence.
Read and follow the instructions carefully.
Pregabalin may be taken with or without food, if you take the tablet form it should be after an evening meal. Swallow it whole. Do not break or chew it.
Dosing:
The dose of this medicine will be different for each patient according to the medical condition.
For diabetic nerve pain:
- 50 mg 3 times a day for adults.
- Children’s dose must be determined by your doctor.
For partial-onset seizures:
- 150 mg per day given in 2 or 3 divided doses for adults.
- The usual dose is 2.5 mg/kg per day given in 2 or 3 divided doses for children one month of age and older weighing 30 kg or more.
- The usual dose is 3.5 mg/kg per day given in 3 divided doses for children one month of age and older weighing less than 30 kg.
For children younger than one month dose must be determined by your doctor.
- 75 mg 2 times a day for adults.
For children, check with your doctor.
For post herpetic neuralgia:
For oral dosage forms (capsules and solution):
- 75 to 150 mg 2 times a day, or 50 to 100 mg 3 times a day for adults.
For children, check with your doctor.
For oral dosage forms (extended-release tablets):
- 165 mg once a day for 1 week for adults.
For children, check with your doctor.
For spinal cord injury nerve pain:
For oral dosage forms (capsules and solution):
- 75 mg 2 times a day for adults.
For children, check with your doctor.
Consult your doctor:
This medicine is only taken as prescribed by your doctor, your doctor may recommend starting this medication at a low dose and gradually increase it, though in some cases that experience allergy or other side effects the doctor may reduce the dose gradually.
To get the most benefit from it use this medication regularly, at evenly spaced intervals.
Although it has many benefits, this medication may sometimes cause addiction.
You should follow your doctor’s instructions carefully to lower the risk of addiction.
Do not stop taking this medication suddenly without consulting your doctor as it may worsen your condition.
Precautions:
Your doctor must check the progress of treatment at regular visits, especially at the beginning of treatment. He may need to perform dose adjustments and to make sure this medicine is working properly. Blood analysis may be recommended to ensure safety from any unwanted effects.
Before taking Pregabalin 75mg, the following should be considered:
Allergies:
Tell your doctor if you are allergic to this medicine or any other medicines.
Any other allergies should be monitored such as allergies to food, dyes, animals, or preservatives.
Geriatric Patients:
Elderly patients are more susceptible to side effects such as dizziness, confusion, blurred vision, or clumsiness, which may require an adjustment in the dose.
Breastfeeding:
There are no adequate studies for determining infant risk when using this medication during breastfeeding. However, weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Other Medical Problems:
Make sure you tell your doctor if you have any of the following conditions:
- Alcohol or drug abuse.
- Angioedema (severe swelling).
- Congestive heart failure.
- Behavior changes.
- Bleeding disorder.
- History of Depression.
- Edema (body swelling or fluid retention).
- Heart rhythm problems.
- Lung or breathing problems (respiratory depression).
- Thrombocytopenia (low platelets in the blood).
- Kidney disease.
Safety of Pregabalin 75mg in Pregnancy:
Pregabalin use in pregnancy is best restricted to circumstances in which the risk-benefit ratio is favorable, (the risks of taking the medicine must be weighed against the good it will do).
Side Effects:
You should call your doctor immediately if any of the following side effects occur:
Less common
- Chest pain
- pale skin
- cough
- muscle aches, or weakness
- noisy breathing
- seizures
- tightness in the chest
Some other side effects may occur but do not need medical attention such as:
More common:
- Accidental injury
- blurred vision
- burning
- acute pain in the hands, feet, arms, or legs
- numbness
- tingling
- change in walking and balance
- headache
- loss of memory
- pain in the lower back or side
- painful or difficult urination
- poor insight and judgment
- problems with memory or speech
- rapid weight gain
- difficulty with speaking
- double vision
- dry mouth
- the sensation of pins and needles
Less common
- Anxiety
- feeling of fullness
- decrease or change in vision
- depression
- eye disorder
- false or unusual sense of well-being
- the general feeling of discomfort or illness
- increased hunger
- loss of appetite
- loss of bladder control
- loss of strength or energy
- nervousness
- nightmares
- pain
Storage:
Store Pregabalin in a closed container at room temperature, away from heat, moisture, and direct light.
Avoid freezing and keep out of reach of children.
Pregabalin for pain
Pregabalin for pain
Pain, this sensation that ranges from just an annoying feeling to a debilitating feeling that can impede the life of the patient.
| Thumbnail | Name | Categories | Date | Price | Buy |
|---|---|---|---|---|---|
| Lyrica pregabalin 150mg generic | Pain relief | 2020-07-01 06:22 | £25.00 – £133.00 | Add to cart This product has multiple variants. The options may be chosen on the product page £25.00 £93.00 £133.00 |
Two kinds of pain are specifically very irritating, Neuropathy and Neuralgia.
Neuropathy is pain, numbness, tingling, swelling, or muscle weakness in different parts of the body, it usually occurs in the hands or feet, and worsens with time.
Neuralgia happens as a result of damage or irritation to the nerve which causes pain along the nerve pathway.
This pain is illustrated as burning, stabbing, sharp or shocking pain.
And we have the drug for both kinds of pain, and other kinds of pain also, Pregabalin for pain.
What is Pregabalin for pain?
Pregabalin got approval from the United States FDA (Food and Drug Administration) for the management of neuropathic pain caused by diabetes, spinal cord injury, and postherpetic neuralgia.
It is also got approval for the management of pain caused by fibromyalgia.
Pregabalin is used for chronic pain conditions not approved by FDA.
Pregabalin is not just for pain, it is also used as adjunctive therapy for partial-onset seizures.
Off-label uses like generalized anxiety disorder, social anxiety disorder, bipolar disorder, and insomnia.
How does Pregabalin for pain work?
Pregabalin for pain controls the chemicals which send the pain signals to nerves, to reduce how much you feel the pain you suffer from.
Dosage and administration:
Pregabalin for pain is found in many dosage forms and concentrations.
Capsules, extended-release tablets, and oral solutions.
It is not found as injectable forms.
In the management of peripheral neuropathic pain caused by diabetes:
Regular-release capsules
- Start the dose by 50 mg orally every 8 hours.
- It may be increased to 100 mg orally every 8 hours within 1 week according to the medical condition.
- Maximum dose: The dose should not exceed 300 mg per day.
pregabalin for pain
- Start the dose by 165 mg orally every 24 hours.
- It may be increased to 330 mg orally every 24 hours within 1 week according to the medical condition.
- Maximum dose: The dose should not exceed 330 mg per day.
In the management of postherpetic neuralgia:
Regular-release capsules
- Start the dose by 150-300 mg orally every 8-12 hours.
- It may be increased to 300 mg orally every 8-12 hours within 1 week according to the medical condition.
Extended-release tablets
- Start the dose by 165 mg orally every 24 hours.
- It may be increased to 330 mg orally every 24 hours within 1 week according to the medical condition.
- Maximum dose: 330 mg orally per day.
After 2-4 weeks, the patient may develop tolerance to the dose, so according to the doctor’s advice, the dose may be increased to 660 mg orally per day.
In the management of fibromyalgia (a condition that is characterized by pain as the main symptom of it):
Regular-release capsules and oral solutions are the only forms used for the management of fibromyalgia.
- Start the dose by 75 mg orally every 12 hours.
- It may be increased to 150 mg every 12 hours within 1 week according to the medical condition.
- Doses more than 450 mg per day are not recommended.
In the management of neuropathic pain caused by spinal cord injury:
Regular-release capsules and oral solutions are the only forms used for the management of neuropathic pain caused by spinal cord injury.
- Start the dose by 75 mg orally every 12 hours.
- It may be increased to 150 mg every 12 hours within 1 week according to the medical condition.
After 2-3 weeks, tolerance to the dose may occur; the doctor may advise increasing the dose to 600 mg per day.
- For patients suffering from any form of renal impairment, the doctor will change the dose according to the condition of the patient.
Warnings:
- Patients who suffer from hypersensitivity to Pregabalin for pain cannot take this drug at all.
- If you suffer from any kind of hypersensitivity, you must tell your doctor before taking pregabalin for pain.
- If you are taking thiazolidinedione antidiabetic drugs, peripheral edema and weight gain are highly susceptible to occur.
- Before consuming Pregabalin for pain, you must understand how you will react to the dizziness and somnolence caused by it before driving or performing any hazardous activities.
This may cause dangerous accidents.
- Symptoms like insomnia, nausea, headache, anxiety and diarrhea were stated after the sudden stop of Pregabalin for pain, even increased seizures with patients with seizures disorder.
Pregabalin for pain should not be stopped suddenly; it should be decreased gradually to avoid withdrawal symptoms.
Pregabalin for pain is potent, very effective, and fewer side effects causing drugs.
Consult with your doctor about the benefits and harms of Pregabalin for pain, and how effective it will be for your condition.
