Know What’s Lyrica, use and possible drug interactions.
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What is Lyrica?
Lyrica is a brand name of a prescription medication called pregabalin. It’s an FDA-approved medication. It’s indicated for use in adults with the following conditions:
- diabetic neuropathic pain
- neuropathic pain from a spinal cord injury
- fibromyalgia (a rheumatic condition distinguished by musculoskeletal pain)
- neuropathic pain after shingles
- partial-onset seizures (as adjuvant therapy with other seizure drugs)
How long does it take to work?
Lyrica pills begin to work very fast. Almost as soon as you take your dose. However, your pain may not be relieved instantly.
Some studies showed that some adults taking this medication reported a decrease in pain within 7 days of starting treatment. You may still need several weeks on this medication to feel that your symptoms are relieved.
How long does Lyrica stay in your system?
After taking the last dose, Lyrica can stay in your body for about 31 hours.
Lyrica in specific populations
There are no adequate reports and well-controlled studies on Lyrica pill use in pregnant women. However, it could be given during pregnancy when there are no alternatives to the underlining case and benefits outweigh the risks.
Studies on animals have shown increased incidences of fetal structural and functional abnormalities. The fetus might be at risk of skeletal malformations, retarded ossification, and decreased fetal body weight.
Women using Lyrica should be informed of the potential risk to a fetus.
Fertile Women should be advised to use reliable contraception during treatment with this medication.
It’s thought that 7% of the maternal weight-adjusted dose will be excreted in breast milk.
Breastfeeding while using these Lyrica pills is not recommended.
Animal Studies showed tumorigenicity in 2 different strains of mice.
Due to the potential risk of carcinogenicity, mothers who are breastfeeding their babies shouldn’t take this medication.
In controlled clinical studies of pregabalin in neuropathic pain associated with diabetic peripheral neuropathy, neuropathic pain associated with postherpetic neuralgia and epilepsy, it’s found that No overall differences in safety and efficacy were observed between patients older than 75 years old and younger patients.
In controlled clinical studies of LYRICA in fibromyalgia, the adverse reaction profile was similar between the two age groups, but some side effects were more frequent in patients 65 years or older. These side reactions include a balance disorder, dizziness, tremor, confusional state, blurred vision, and coordination abnormality.
Lyrica pill is mainly excreted by the kidney. Patients with impaired renal function may be at higher risk of toxicity.
The dosing should be modified for older patients with renal impairment.
Lyrica, like any medication, can cause interactions with other substances taken by the patient (drug, alcohol or even food).
Before taking this medication, inform your doctor and pharmacist of all the medications you use, (including prescription drugs, nonprescription drugs, vitamins, supplements and herbal medicines).
Detailed information can help you avoid potential interactions.
Here is a list of medications that may interact with Lyrica pills. This list includes but is not limited to:
Lyrica and CNS depressants
Your CNS (your brain and spinal cord) could be affected by Lyrica. To help understand, your brain sends signals throughout your body through nerves originated from the spinal cord.
A CNS depressant (such as Lyrica) works by slowing down your CNS. This may cause side effects such as sedation, drowsiness and respiratory depression. Other CNS depressants affect your body in the same way. Combining two or more CNS depressants exaggerates the sedative effect of each other.
Some examples of CNS depressants include:
- opioid medications (pain killers)
- benzodiazepines (alprazolam, diazepam,.. etc)
- muscle relaxers like cyclobenzaprine and baclofen
Before you take Lyrica pills, tell your doctor if you’re using any of the previous drugs.
You probably will be monitored for any symptoms of increased sedation or respiratory problems during your treatment period.
Your doctor may decide to alter your medication doses or try different drugs for your condition.
Lyrica and alcohol
Lyrica shouldn’t be taken while drinking alcohol. Alcohol is a central nervous system sedative.
Combining the two substances could raise your risk for certain neurogenic side effects, such as drowsiness, sleepiness, dizziness, and respiratory depression.
Before you begin treatment with Lyrica, Tell your doctor if you drink alcohol.
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This is a part of what you should know about Lyrica pills.
Ask your doctor and pharmacist for further explanation and make sure that the information here is suitable for your circumstances.