Pregabalin withdrawal symptoms
Pregabalin withdrawal symptoms
Pregabalin, the ultimately famous drug, has so many uses, in so many different diseases.
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It is used in relieving nerve pain, some types of seizures, in addition to other anticonvulsants in the treatment of partial-onset seizures, neuropathic pain associated with diabetes or spinal cord injury, treatment of fibromyalgia, postherpetic neuralgia.
Pregabalin may be also used off-label for generalized anxiety disorder, hot flashes, restless leg syndrome (the urge to move your legs, it usually happens during the night), and social anxiety disorder.
But Pregabalin is not always that good, inappropriately taking Pregabalin may cause Pregabalin withdrawal symptoms when trying to stop it.
Always use Pregabalin exactly as described by your physician to take the ultimate benefit from it, and avoid the risks.
What is Pregabalin?
Pregabalin is a prescription need drug that is available in many dosage forms, capsules, solutions, and extended-release tablets.
All the dosage forms of Pregabalin are taken orally, not available as neither injection nor rectal forms.
How does it work?
- It is used in epilepsy by reducing the abnormal electrical activity in the brain.
- It also blocks pain by interfering with the messages of pain moving through the brain and down the spine that’s how it is used in nerve pain.
- In treating anxiety, Pregabalin stops the brain from releasing the chemicals responsible for the feeling of anxiety.
Pregabalin withdrawal symptoms
Dosage:
To avoid suffering from Pregabalin withdrawal symptoms, you must follow the directions of your physician strictly.
The dose is usually based on age, weight, and medical condition.
The dose may always be modified by your physician according to the response to treatment.
Pediatrics
For the treatment of partial-onset seizures:
Extended-release tablets are not used in pediatrics, with regular capsules and oral solutions only.
It is used in patients older than 1-month-old.
From 1 month – 17 years old:
Starting dose: 3.5 mg/kg/day taken orally in divided doses every 8 hours from 1 month – 4 years or every 8-12 hours for those older than 4 years old.
Maintenance dose: The dose may be increased weekly till it reaches 10 mg/kg/day.
Maximum dose: The dose not to exceed 600 mg/day.
Older than 17 years old:
Starting dose: 150 mg/day taken orally in divided doses every 8-12 hours.
Maintenance dose: The dose may be increased daily, but not to exceed 600 mg/day.
The use in children with renal impairment has not been studied.
Adults
For the treatment of the neuropathic pain caused by diabetes:
Regular-release capsules
Starting dose: 50 mg orally every 8 hours
Maintenance dose: The dose may be increased to 100 mg orally every 8 hours within 1 week if needed, but not to exceed 300 mg/day.
Extended-release tablets
Starting dose: 165 mg orally per day
Maintenance dose: the dose may be increased to 330 mg orally per day within 1 week, and it is the maximum dose allowed.
For the treatment of postherpetic neuralgia:
Regular-release tablets
Starting dose: 150-300 mg/day orally divided every 8-12 hours
Maintenance dose: The dose may be increased to 300 mg/day divided every 8-12 hours after 1 week if needed.
Extended-release tablets
Starting dose: 165 mg orally per day
Maintenance dose: The dose may be increased to 330 mg orally per day within 1 week, and it the maximum dose allowed
For the treatment of fibromyalgia:
It is treated using regular-release capsules and oral solution only.
Starting dose: 75 mg orally every 12 hours
Maintenance dose: The dose may be increased to 150 mg every 12 hours after 1 week if needed.
Maximum dose: 300-400 mg/day
For the treatment of partial-onset seizures:
It is used as adjunctive therapy using regular-release capsules and oral solution only.
Starting dose: 150 mg/day orally divided every 8-12 hours
Maximum dose: 600 mg/day
For the treatment of neuropathic pain caused by an injury to the spinal cord:
It is treated using regular-release capsules and oral solution only.
Starting dose: 75 mg orally every 12 hours
Maintenance dose: The dose may be increased to 300 mg/day orally divided every 12 hours
If tolerance occurred the dose may be increased to 600 mg/day divided every 12 hours
Stopping Pregabalin suddenly may cause withdrawal symptoms; the dose should be decreased gradually.
Your doctor will tapper the dose for you to avoid pregabalin withdrawal symptoms.
Pregabalin withdrawal symptoms:
- Seizures
- Dizziness
- Diarrhea
- Nausea
- Headaches
- Vomiting
- Irritability
- Sleeping troubles
- Nightmares
- Tingling feelings
Pregabalin withdrawal symptoms especially happen when taking high doses for a long time or abusing it.
If you feel any of the above symptoms, make sure to contact your doctor immediately.
Pregabalin is a very good and effective drug to be used for intended medical conditions, not for addictive reasons.
Don’t take Pregabalin without being prescribed by a physician and without a prescription or else you may suffer from Pregabalin withdrawal symptoms.
Get Pregabalin from trusted sources like pharma stores to avoid any unwanted effects.
Pregabalin anxiety
Pregabalin anxiety
Anxiety is a normal feeling that haunts mankind; you can feel anxiety due to a job interview, the first day of school, or about what is going to happen in the future.
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This kind of anxiety can encourage you to accomplish what you want.
But this feeling may transform into a disorder, feelings become extreme, and last for longer than six months, interferes with your life, and cause a pause from accomplishments.
Generalized anxiety disorder is persistent worrying about several things, not one.
Pregabalin anxiety is one of the very effective drugs to control this disorder and return your life to normal.
It took 79% positive reviews on the treatment of generalized anxiety disorder.
According to a placebo-controlled trial published in the American Journal of Psychiatry in March 2003, Pregabalin anxiety was almost as effective as benzodiazepines.
It even overweighs benzodiazepines that it has fewer withdrawal symptoms.
Generalized anxiety disorder signs and symptoms:
- Fatigue
- Sleeping problems
- Tension
- Muscle aches
- Trembling
- Nervousness
- Sweating
- Nausea
- Diarrhea
- Irritability
The use of Pregabalin doesn’t stop on generalized anxiety disorder, it has many other uses.
It is used in:
- Peripheral neuropathic pain associated with diabetes.
- Postherpetic neuralgia.
- Partial onset seizures.
- Neuropathic pain after spinal cord injury.
Before taking this drug, make sure to inform your doctor about:
- Heart problems
- Kidney problems
- Breathing problems
- History of drug or alcohol use
Dosage and administration:
Pregabalin is available in oral dosage forms only.
Capsules with 25, 50, 75, 100, 150, 200, 225, and 300 mg concentrations
Oral solution with concentration of 20 mg/ ml
Extended-release tablets with 82.5, 165, and 330 mg concentrations
Dosage for Generalized anxiety disorder treatment:
The dose ranges between 150-600 mg daily divided every 8-12 hours.
Starting with 150 mg daily.
The dose may be increased according to the medical condition and response to treatment; it can be increased to 300 mg daily after 1 week.
Then to 450 mg after another week if needed.
Maximum dose: pregabalin 600 mg daily
For those who suffer from any kind of renal impairment, the dose should be adjusted according to the results of the lab tests.
- Take Pregabalin anxiety with or without food, it doesn’t matter.
- If you missed a dose, take it as soon as possible except it is the time for the next one, skip it and go back to the normal regimen.
Don’t double the dose.
- If you are using extended-release tablets, don’t split, crush nor chew the tablet.
- Take Pregabalin anxiety at the same time every day.
- It is preferable to be taken after the evening meal.
- If you missed the dose, take it till after the morning meal, don’t take it after that.
- If you overdosed, go to the nearest hospital or call an ambulance.
- Never stop taking Pregabalin anxiety suddenly, the dose should be decreased gradually, or else the patient will suffer from withdrawal symptoms.
- Seizures
- Dizziness
- Diarrhea
- Nausea
- Headaches
- Vomiting
- Irritability
- Sleeping problems
- Nightmares
- Tingling feeling
If you suffer from any of the above symptoms, consult with your doctor at once.
Always read the pamphlet (Patient information and instructions for use) of the drug before taking it.
Also, talk to your health care provider about any inquiries about the drug.
Side effects:
Common side effects:
- Dizziness
- Drowsiness
- Hands and feet swelling
- Concentrating troubles
- Increased appetite and weight gain
- Dry mouth
- Blurred vision
- Accidental injuries may occur
- Burning feeling in the limbs
- Incoordination
- Confusion
- Speaking difficulties
Less common side effects:
- Chest pain
- Cold sweats
- Pale skin
- Productive cough
- Breathing difficulties
- Muscle aches
- Seizures
This is not a full list of side effects; always talk to your doctor about any symptoms you are experiencing.
Warnings:
- Pregabalin anxiety may cause severe hypersensitivity, if you experience any signs of hives, itching, or swelling of lips and tongue, contact your doctor immediately.
- Don’t drive nor perform hazardous activities before you understand how the drug will affect you.
It causes dizziness and somnolence which may be very dangerous leading to accidents.
- If you have diabetes and noticed any weight gain, you may have to adjust your hypoglycemic drug.
- Dizziness and drowsiness may exacerbate when concomitantly used other drugs used to depress the CNS (Central nervous system).
- Patients with seizure disorders may suffer from increased seizures when they discontinued the drug rapidly.
- Monitor the patient for any signs of depression, suicidal thoughts, or behavior.
If you noticed any of these, contact your doctor at once.
- Using this drug with alcohol will increase the drowsiness caused by Pregabalin anxiety.
- Elders are more sensitive to side effects especially drowsiness, dizziness, unsteadiness, confusion, and shallow breathing.
Pregabalin anxiety is a very good drug that showed great efficacy in many disorders and diseases make sure to consult with your doctor if Pregabalin is suitable for your case especially if you are suffering from generalized anxiety disorder (GAD).
zopiclone tablets
Zopiclone tablets
Zopiclone is one of the ideal hypnotics.
Hypnotics existed since the introduction of benzodiazepines which offer lots of advantages, they are effective and safe to some extent but the ideal hypnotics must have some characteristic like:
- induce and maintain sleep without any hangover effects over the next day.
- Safe use away from abuse (use a drug by a wrong way or for the wrong purpose) and dependence (adaptive state result from long term use of drug and result in withdrawal symptoms if drug stopped).
Zopiclone advantages
Zopiclone tablets is a new ideal hypnotic (sleeping pills) that belongs to a new chemical class, has a lot of advantages:
- Eliminated rapidly from the body; so no residual effects and no residual impairment of cognitive functions.
- No accumulation exists upon repeated administration.
- Its properties are not modified with kidney diseases or with the elderly.
- All clinical trials showed that zopiclone tablets 7.5mg are effective as hypnotic and can improve sleep variables in case of insomnia.
- Discontinuation of zopiclone tablets is not accompanied by rebound effect and relevant withdrawal symptoms.
- Craving studies failed to prove any dependence on zopiclone tablets.
- Side-effects are represented mainly by a bitter taste and dry mouth with a minimal incidence of CNS depressant effects.
- zopiclone tablets have no effect on respiratory functions, all the studies failed to prove any relation.
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Evaluation
Evaluation of the accumulated evidence of zopiclone tablets’ use from over 2.5 billion units dispensed in more than 30 countries indicates that it is effective with almost no side effects and an excellent alternative to benzodiazepines as a short-term treatment of insomnia.
zopiclone tablets
Tips about zopiclone use
- Don’t use zopiclone for more than 4 weeks; zopiclone is not an option for chronic insomnia( lasts for 3 nights a week for more than 3 months). The cause in these cases must be evaluated and treated first.
- Don’t drink any alcoholic beverages while using zopiclone, this may have an additive effect and leads to central nervous system depression.
- Don’t use zopiclone if you are younger than 18 years old.
- Tell your doctor if you have depression or any psychiatric illness or personality disorder.
- You shouldn’t use zopiclone tablets if you have any degree of respiratory failure or sleep apnea (episodes of breathing stopping or shallow breathing during sleeping).
- Use zopiclone tablets with caution if you suffer from any kidney or liver disease.
- Zopiclone tablets contain lactulose so if you have sugar intolerance avoid using them.
Drug-drug interaction:
There are some drugs that interact with zopiclone and change the way zopiclone tablets work some of these drugs:
- Other hypnotics (sleeping pills).
- Antiepileptics drugs like carbamazepine, phenobarbital, and phenytoin.
- Antipsychotics drugs (drugs used to treat psychosis).
- Some pain killers especially those that contain opioids like morphine, oxycodone, pethidine, codeine, and tramadol.
- Drugs used for the treatment of allergy-like chlorpheniramine, promethazine.
- Some antibiotics like rifampicin, clarithromycin, or erythromycin.
- Drugs to treat fungal infections like ketoconazole, itraconazole.
Zopiclone with alcohol
Alcohol consumption must be stopped during taking zopiclone tablets, as alcohol increases the effect of zopiclone be a bad manner and may be a difficulty in waking the next day.
Pregnancy and breast-feeding
If you are pregnant or have a plan to get pregnant talk with your doctor or pharmacist before taking zopiclone tablets.
If you already took it during pregnancy there is an increased risk of cleft lip and palate in the baby.
Taking zopiclone during the last six months of pregnancy can lead to abnormal fetal movement and fetal heart rate changes.
Do not take zopiclone during the last 3 months of pregnancy or during labor, the baby may have low body temperature, muscle weakness, breathing difficulties, difficulty feeding, and show withdrawal symptoms such as shaking after birth or agitation. The newborn should be closely monitored in these cases during the postnatal period.
Breast-feeding
Zopiclone can’t be used during breastfeeding or planning to breastfeed. This is because zopiclone can pass in the mother milk, talk to your doctor or pharmacist before taking any medicine in this situation.
Driving and using machines
Like other sleeping pills, Zopiclone tablets can cause the slowing of your normal mental function (central nervous system CNS depression). The risk of this impairment including driving ability is increased if:
- Within 12 hours of taking zopiclone and performing activities that require alertness
- A higher dose than recommended has been used.
- You are using other sleeping pills or other drugs that cause CNS depression or alcohol or drugs that increase the level of zopiclone tablets.
It is better to avoid driving or using heavy machinery or tools on the day after taking Zopiclone tablets 7.5mg especially if you are feeling drowsy or sleepy.
zopiclone tablets
Using valium for sleep
Valium for sleep
Tranquilizers
are a group of drugs that are used to control anxiety, fear, tension, agitation, and any other mental problems.
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It can be either:
Minor tranquilizers: Anxiolytics (medication reduces anxiety).
Major tranquilizers: Antipsychotics (medication used to manage psychosis which affects how the brain functions).
Valium for sleep is one of the minor tranquilizers that are used for treating anxiety, alcohol withdrawal symptoms, and muscle spasms or stiffness.
Valium is used to treat seizures in combination with other medicines.
It works by controlling the hyperactivity of brain function to relieve severe stress and anxiety.
Valium must be taken under a doctor’s supervision as its dose changes according to the patient’s condition, age, and response to medication and the dose must never be increased by yourself as it may cause some serious side effects and overdose effect as we will discuss later in this article.
You can use valium for sleep and it should be individualized for better effects and the least side effects.
Usual daily doses:
Anxiety: 2mg to 10 mg from 2 to 4 times daily according to the condition.
Alcohol withdrawal: 10 mg 3 to 4 times for the first day then reduced to 5 mg 3 to 4 times daily.
Muscle spasms or stiffness: 2 to 10 mg 3 to 4 times daily.
Elder patients: 2 mg to 2.5 mg, 1 or 2 times daily the can be increased gradually as needed.
Dosage modifications:
if you want to use valium for sleep, please take care if you are suffering from:
Renal impairment: No modification is needed unless for prolonged treatment decrease in dose is recommended.
Hepatic impairment: 50% of the dose should be given only.
You must tell your doctor if you suffer from any of the following medical conditions before you start taking Valium for sleep as they may interfere with the drug:
-
Myasthenia gravis (a disorder of muscle weakness).
-
Severe breathing problems.
-
Sleep apnoea (stop breathing during sleep for short time).
-
Narrow-angle glaucoma.
-
Uncontrolled open-angle glaucoma.
-
Severe liver diseases.
-
Allergy to it.
-
Drug or Alcohol addiction.
-
Any kind of depression including (mood changes or suicidal thoughts).
-
Seizures unless you are taking it for a seizure disorder.
Valium for sleep is a long-acting medication compared to other drugs with the same action; it takes from 30 to 56 hours to get out from the body.
Valium for sleep is very effective, potent, and has a fast onset of action but if it is misused it will easily lead to addiction.
Taking Valium for sleep for longer than 4-6 weeks and with a dose more than acceptable even with a doctor’s prescription will lead to addiction to the drug.
Symptoms of Valium addiction:
- Feeling the need to have more pills to reach the desired effect.
- Craving for the drug before the time for the next dose.
- Become isolated from family and friends.
- Continuation in using the drug although has caused me many problems.
- Loss of interest in any activities or work.
- Ignoring the must-do things.
Even though you must not stop the drug from your own, Valium can cause very serious withdrawal symptoms that may lead to coma and even death.
Valium should be reduced gradually under the supervision of a doctor.
“Taking up to 60 tablets per day was not enough anymore to reach euphoria they were barely enough to reach somehow normal”
Valium is more likely to be used for those who struggle with the daily stress which affects their sleeping quality, it gives them calmness and euphoria especially with high doses, and those who are most vulnerable to addiction.
“Valium was making me not caring for the world anymore even if the house got on fire, I would say so what?!”
Overdosing is highly dangerous as it may lead to:
- Bluish lips.
- Double vision.
- Difficulty breathing.
- General weakness.
- Difficulty in coordination.
“Benzodiazepines (tranquilizers like Valium and Xanax) and opioids (it is a class of drugs that include illegal heroin, synthetic opioids such as fentanyl, and pain relievers legally available by a prescription like oxycodone, hydrocodone, codeine, morphine, and many others) strengthen each other giving higher effects of both of them but they can also cause death.”
– Dr. Michael Kelley, NPR, 2014
Valium may also counteract with some food like grapefruit, consuming large amounts of grapefruit or grapefruit juice strengthen the effects of Valium and can cause serious side effects.
Side effects:
- Severe allergic reaction.
- Hives (Urticaria).
- Difficulty breathing.
- Swelling of face, lips, tongue, and throat.
- Severe drowsiness or dizziness.
- Mood or behavior changes.
- Anxiety, depression, or worsening of both of them.
- Suicidal thoughts.
- Sleeping problems.
In 2011, 14.7 million prescriptions of Valium were written to patients.
Abuse of Valium was first noticed in 2013 as 1.2 million persons were reported to have abused Valium.
Addiction rehab centers are always there for those who fall into addiction with the help of very good and specialized doctors and psychiatrists.
valium for sleep reviews
