Diazepam 25 mg
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Diazepam 25 mg
Have you ever heard about diazepam with a concentration of 25 mg?
The maximum dose we know is the rectal gel form with the concentration of 20 mg, till came the breakthrough of West-Ward Pharmaceuticals Corporation when they came out with Diazepam 25 mg in Diazepam Intensol Oral solution which contains 25 mg per 5 ml.
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Diazepam 25 mg is a benzodiazepine that has anti-anxiety, sedative, muscle-relaxant, anticonvulsant, and amnestic effects.
It works on the brain, on a certain type of transmitters, called GABA (Gamma-aminobutyric acid), which helps in the inhibition of the excessive activity of the Central Nervous System (CNS).
Indications:
Diazepam 25 mg is indicated for anxiety disorders and anxiety symptoms.
When we say anxiety, we don’t mean the daily anxiety coming from work or family, but we mean that type that is affecting our daily life and preventing us from doing our normal activities in a normal way.
Diazepam is also indicated in the symptomatic relief of alcohol withdrawal, like acute agitation, tremor, impending or acute delirium tremens, and hallucinosis.
It is used as adjunctive therapy for the relaxation of skeletal muscle spasms happening due to reflex spasms to local pathologies, such as inflammation of the muscles or joints, or it happens as a result of trauma.
Muscle spasms may also be a result of spasticity caused by upper motor neuron disorders, such as cerebral palsy (a group of disorders affecting the ability of the patient to move and maintain balance and posture) and paraplegia (a type of paralysis affecting the ability to move the lower half of the body), athetosis (slow, involuntary, and writhing movements of a group of muscles including the limbs, face, neck, tongue, and others), and stiff-man syndrome (a rare neurological syndrome with features of autoimmune disease).
Diazepam 25 mg may be also used adjunctively in convulsive disorders.
Diazepam is not intended for use for more than 4 months, that’s why the effectiveness and safety should be reassessed regularly by your physician.
Contraindications:
Diazepam 25 mg is contraindicated to be used in patients with known hypersensitivity to this active constituent.
It is contraindicated also in pediatrics under 6 months as there is no sufficient clinical experience for the use of diazepam in this age.
Diazepam should not be used in patients suffering from myasthenia gravis (weakness of muscles), severe respiratory insufficiency, severe hepatic impairment, and sleep apnea (breathing stops for a short period during sleep).
It may be used in patients with a controlled case of open-angled glaucoma, but may not be used with acute narrow-angled glaucoma.
Warnings:
Why did the FDA (Food and drug administration) issued a black box warning about using diazepam 25 mg with opioids?
Due to observational studies, the concomitant use of opioids and benzodiazepines was found to increase drug-related mortality, especially when compared with the use of opioids alone.
Using them together results in profound sedation, respiratory depression, coma, and death.
That’s why using opioids in combination with diazepam 25 mg is limited when alternatives are inadequate.
Why diazepam 25 mg can’t be given to patients with a history of substance abuse?
Using diazepam 25 mg may lead to misuse, abuse, and addiction.
This may cause overdosing which may lead to death.
Overdosing may be illustrated in the following symptoms:
- Extreme drowsiness
- Loss of balance or coordination
- Limp or weak muscles
- Slow breathing
- Coma which may eventually lead to death
Using diazepam 25 mg for a long time may cause withdrawal symptoms while stopping the drug.
Stopping the take of diazepam should be done gradually and under the supervision of a doctor to avoid withdrawal symptoms such as,
- Abdominal cramps
- Headache
- Tremors
- Sweating
- Muscles pain
- Vomiting
- Severe anxiety
- Confusion
- Restlessness and Insomnia (sleeping problems)
- Numbness
- Panic attacks
- Memory issues
- Weakness
- Reduced appetite
- Sensory hypersensitivity (high sensitivity to stimulation of the senses)
- Heart palpitations
- Muscle twitching
More serious symptoms including:
- Hallucinations
- Depersonalization
- Seizures
- Delirium
- Psychosis
- Convulsions
- Coma
- Death
Taking diazepam 25 mg with other drugs may also lead to undesirable side effects that may be serious.
Serious – use alternative
- abametapir
- apalutamide
- benzhydrocodone/acetaminophen
- calcium/magnesium/potassium/sodium oxybates
- carbamazepine
- cimetidine
- clarithromycin
- darunavir
- erythromycin base
- erythromycin ethylsuccinate
- erythromycin lactobionate
- erythromycin stearate
- fedratinib
- fexinidazole
- hydrocodone
- idelalisib
- ivosidenib
- ketoconazole
- lonafarnib
- metoclopramide intranasal
- mifepristone
- nefazodone
- rifabutin
Pregnancy:
Using benzodiazepines during pregnancy is associated with an increased risk of congenital malformations and other developmental abnormalities.
Respiratory and feeding difficulties have been reported with the use of diazepam 25 mg during pregnancy.
Nursing mothers:
Diazepam was proved to pass into breast milk. Therefore, breastfeeding is not recommended while using diazepam.
Diazepam 25 mg is characterized to be in an oral solution form, which makes it easier to be taken, with the higher concentration allowing the patient to take less amount for fewer times.
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