Diazepam mechanism

Diazepam mechanism

Diazepam mechanism:

• Diazepam, which is commonly known in the market by Valium, belongs to the benzodiazepine group.

• Benzodiazepine groups act by binding with a specific receptor in the brain and spinal cord, this binding causing inhibitory effect of nerves.
• Due to this action, diazepam and benzodiazepine have anxiolytic effects.
• Benzodiazepines contain diazepam, alprazolam, flurazepam, clonazepam, lorazepam, estazolam, chlordiazepoxide, clorazepate and other.

Diazepam mechanism indications for use:

• Sedations before surgery.
• Sleeping disorder.
• Alcohol withdrawal symptoms.
• Neuroleptic malignant syndrome.

Diazepam mechanism dosage forms and strengths:

Diazepam is available in different dosage forms and variant concentrations:

• Tablets: are available 2mg, 5mg, 10mg.
• Oral solutions: available in concentration 5mg/5ml
• Injections: available in concentration 5mg/ml.
• Rectal gel: available in concentration 2.5mg, 10mg, 20mg.

Diazepam mechanism tips and instructions for use:

You should follow your doctors’ instructions about the use and administration of diazepam:

• You should swallow the whole tablet with a glass of water.
• You should not try to chew or crush the tablet.
• You should not use diazepam for a long duration.
• You should not stop diazepam suddenly.

Diazepam mechanism side effects:

There are many side effects of diazepam, you should carefully read the drug leaflet and talk with your doctor if you feel one of the following.

More common side effects of diazepam:

• Allergic and hypersensitivity reaction.
• Abdominal pain.
• Blurred vision.
• Difficulty in urination.
• Dry mouth.
• Elevated liver enzyme.
• Increase appetite.
• Impaired motor ability.
• Memory impairment.
• Muscle weakness.
• Nasal congestion.
• Respiratory depression.
• Skin rash and urticaria.
• Trouble in speaking.

In severe cases, you may feel more severe symptoms, so in that case, you should call your doctor immediately.

Example of severe side effects:

• Anxiety as the new onset.
• Worsening anxiety.
• Change in behavior and mood.
• Excessive increase in activity and talking.
• Panic attacks.
• Trouble in sleeping.
• Thought about suicides.

Things you should not do during the treatment with the diazepam mechanism:

• You should not drive.
• You should not operate machinery.
• You should not drink alcohol.
• You should not eat or drink grapefruits.
• you should not stop diazepam suddenly.
• You should not use diazepam for a long duration.
• You should not use diazepam in concomitant use with another CNS depressant.
• You should not use diazepam if you age above 65 years.
• You should not use diazepam if your pregnancy test is positive.
• You should not use diazepam if you are planning to be pregnant.

Diazepam mechanism contraindications:

You need to discuss with your doctor if you have the following medical conditions:

• If you have an allergy or hypersensitivity reaction to diazepam or benzodiazepines.
• If you have a psychotic disorder like depression.
• If you have myasthenia gravis disease which is a medical condition causing muscle weakness due to an autoimmune condition.
• If you have a respiratory disorder like respiratory depression or sleep apnea.
• If you have severe liver disease.
• If you are planning to be pregnant or are already pregnant.
• If you have porphyria which is an inherited medical condition causing skin blisters, abdominal pain, nervous system disorder.

Diazepam mechanism withdrawal symptoms:

• Withdrawal symptoms occur when using diazepam for a longer duration or stopping diazepam suddenly.
• Under the supervision of your doctor, to stop the medication you will taper the dose gradually.

Symptoms of withdrawal:

• Upset stomach.
• Mood changes.
• Panic attacks.
• Suicidal thoughts.

Diazepam mechanism overdosing:

Causes of diazepam overdose:

• If you have taken a lot of tablets.
• Concomitant use of medications increases the effect of diazepam.
• Concomitant drinking alcohol or grapefruits.

Overdosing symptoms:

 

• Low blood pressure.
• Upset stomach.
• Respiratory depression.
• Muscle weakness.
• Blurred vision.
• Reflex problems.
• Breathing difficulties.

Treatment of diazepam overdosing:

If you feel one of the overdosing symptoms:

• You should stop diazepam.
• Call your doctor immediately.
• Visit the emergency department of the nearest hospital.

Management of diazepam overdose:

Under the supervision of the doctor:

• The doctor may give you an activated charcoal to decrease the amount absorbed from the gut.
• The doctor will protect your airway.
• The doctor will manage the low blood pressure.
• The doctor may give you an antidote called flumazenil.

Antidote flumazenil act by counteracting the effect of diazepam.

Diazepam mechanism missed dose:

• You should not take a double dose, if you missed one
• Take the second dose at the right scheduled time.

Diazepam mechanism warnings and precautions:

Talk to your doctor or pharmacist before using diazepam if you have one of the following conditions:

• If you have severe renal impairment.
• If you are smoking.
• If you have suicidal thoughts.
• If you have breathing difficulties.
• If you are elderly.
• If you have heart or lung problems.
• If you have arteriosclerosis: poor blood supply to the brain.

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Diazepam action