Does Pregabalin cause weight gain?
Table of Contents
Does Pregabalin cause weight gain?
If you are asking “does pregabalin cause weight gain?”. The answer is yes.
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There are a lot of drugs that induce weight gain, weight gain is a very serious and annoying side effect. One of these drugs is pregabalin.
Weight gain can lead to stopping the therapy and exacerbating a lot of medical conditions, weight gain is a problem that can lead to glycemic control and increasing blood pressure or worsening lipid profile.
Patients can control weight gain by adhering to a suitable diet and exercise or even they can take drugs to control this problem.
This problem is common with most antipsychotics drugs like clozapine risperidone olanzapine and quetiapine, and also some antidepressant such as mirtazapine and amitriptyline, and this problem are not related to the disease severity but related to the drug itself.
The same phenomenon is related to some Antiepileptic drugs (AEDs) and mood stablilizers like carbamazepine, valproate, and gabapentin.
A meta-analysis (a study that analyses the results of independent studies of the same topic to determine overall trends) included 106 studies and 43,525 patients, that published in 2012 by the Current Medical Research and Opinion concluded that 70% of pregabalin users by a dose of 150 to 600 mg once daily maintained 7% of baseline weight.
1 in 6 patients gained more than 7% from baseline One in six patients gained ≥7% weight from baseline.
In pregabalin controlled clinical trials in adult patients which lasted for 14 weeks, a gain of 7% or more over baseline weight was observed in 9% of pregabalin-treated patients. Few patients treated with pregabalin (0.3%) could not complete the controlled trials due to weight gain.
pregabalin associated weight gain was related to dose and duration of exposure, increasing the dose increases the chances of weight gain as doses of 600 mg were associated with a higher percentage of weight gain but the percentage did not appear to be associated with baseline BMI, gender, or age.
Although weight gain related to pregabalin was not associated with clinically important changes in blood pressure in short-term use, the long-term cardiovascular effects of pregabalin-associated weight gain are not clear.
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Pregabaline and diabetes:
If you are a diabetic patient you should ask about does pregabalin cause weight gain?
Among diabetic patients, pregabalin-treated patients gained an average of 1.6 kg (range: -16 to 16 kg), In a study of 333 diabetic patients who received pregabalin for at least 2 years, the average weight gain was 5.2 kg.
While the effects of pregabalin-associated weight gain on glycemic control have not been systematically assessed, in controlled and longer-term clinical trials with diabetic patients, pregabalin treatment did not appear to be associated with loss of glycemic control.
Pregabaline and heart failure:
Pregabaline can cause peripheral oedema (swelling of limbs), so caution must be paid to the patient with heart failure and with patients using other drugs that cause peripheral oedema like thiazolidinedione antidiabetic drug (rosiglitazone, pioglitazone).
The incidence of peripheral oedema associated with pregabalin was 6% and only 0.5% stopped the medication and withdraw from controlled clinical trials.
There are a lot of studies that tried to relate between pregabalin and heart failure as pregabalin can cause fluid retention and weight gain which may be an overload to the heart, but none of them was able to confirm that pregabalin can cause heart failure or exacerbation to chronic heart failure.
This may answer the patient who always asking ‘Does pregabalin cause heart failure?’ ‘Does pregabalin cause weight gain?’.
There are a lot other common adverse events related to pregabalin such as:
Common adverse events:
- Sore throat.
- Increased appetite.
- Decrease in sexual interest, feeling of elation, confusion, disorientation, irritability.
- Disturbance in attention, clumsiness, memory impairment, loss of memory, tremor, difficulty with speaking, tingling feeling, numbness, sedation, lethargy, insomnia, fatigue, feeling abnormal.
- Blurred vision, double vision.
- Vertigo, problems with balance, fall.
- Dry mouth, vomiting, flatulence, constipation, nausea, swollen abdomen, diarrhoea.
- Difficulties with erection.
- Abnormal style of walking, Feeling drunk.
- Joint pain, pain in limb, muscle cramp, back pain.
Rare adverse event:
- Swinging vision, vision loss, abnormal sense of smell, visual brightness, altered perception of depth.
- Dilated pupils, cross eyes.
- Cold sweat, tightness of the throat, swollen tongue.
- Inflammation of the pancreas.
- Difficulty in swallowing.
- Slow or reduced movement of the body.
- Difficulty with writing properly.
- Increased fluid in the abdomen.
- Fluid in the lungs.
- Changes in heart rhythm.
- Muscle damage.
- Abnormal breast growth, breast discharge, breast growth in males.
- Interrupted menstrual periods.
- Kidney failure, reduced urine volume, urinary retention.
- Decrease in white blood cell count.
- Inappropriate behaviour.
- Jaundice (yellowing of the skin and eyes).
Serious adverse events:
- life-threatening allergic reactions.
- Suicidal thoughts.
- Swelling of peripheral limbs.
- Serious problems with breathing.
We hope that we explain if “Does Pregabalin cause weight gain?” was useful to you. Rememberer always to ask your doctor or pharmacist before any medical decision.
Gabapentin V Pregabalin
Table of Contents
Gabapentin V Pregabalin
A better drug with lower cost, it is also used in lower doses, yes, it is Gabapentin V Pregabalin but of course, Pregabalin has always won the competition.
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What is Gabapentin?
Gabapentin is an anticonvulsant drug that affects chemicals and nerves causing seizures and some types of pain.
It is used in combination with other drugs to treat partial seizures in adults and children older than 3 years old.
Gabapentin is also used for treating neuropathic pain (pain due to damaged or diseased nerve) caused by the herpes virus or herpes zoster (shingles) in adults.
Gabapentin V Pregabalin, so What is Pregabalin?
Pregabalin is also an anticonvulsant drug; it slows down the impulses causing seizures in the brain.
It also affects the chemicals that send signals of pain through the nervous system, so it is used to treat pain caused by fibromyalgia (condition distinguished by pain throw out the body, or neuropathic pain of diabetic patients, neuralgia caused by herpes zoster (severe pain due to damaged nerve), or that pain coming after spinal cord injury.
Pregabalin is used as adjunctive therapy in treating partial-onset seizures in adults and children older than 1 month old.
It also has off-label uses, generalized anxiety disorder, social anxiety disorder, bipolar disorder, insomnia, and chronic pain disorders like sciatica and others.
So both of them are used for peripheral neuropathic pain and post-herpetic neuralgia, but what are the differences of Gabapentin V Pregabalin?
Let’s take the point after the other.
-
Cost:
According to a hypothetical cohort of 1000 patients, Pregabalin was found to be much more cost-effective than gabapentin.
According to a retrospective cohort of palliative care outpatients at the University of Arkansas for medical sciences (UAMS) palliative care clinic (PCC), no significant difference was found in terms of effectiveness.
But there was a significant difference in the number of pills taken and the discontinuation of the drug as a result of side effects.
Gabapentin V Pregabalin showed an advantage over Pregabalin as the average number of pills needed for Pregabalin was 0.01, while gabapentin was 1.8.
Pregabalin also showed superiority in the number decreasing the dose due to adverse effects caused, as those treated with gabapentin were decreasing the dose more than Pregabalin.
Pregabalin was much more tolerated than gabapentin.
gabapantin v pregabalin
Gabapentin is more likely to cause speaking difficulties, fever, and increased susceptibility to viral infections, unusual eye movements, and jerky movements (fast uncontrollable movements with no purpose.
Pregabalin is more likely to cause dry mouth, constipation, edema (swelling), breast enlargement, and weight gain.
- Absorption:
Gabapentin V Pregabalin, Pregabalin also shows superiority in absorption, it is absorbed faster and works more quickly than gabapentin.
Pregabalin reaches the maximum concentration in the blood within an hour, whereas gabapentin takes about 3-4 hours.
-
Interactions:
Although Gabapentin V Pregabalin has similar interactions as they belong to the same class of medicine, gabapentin also interacts with NSAIDs (Non-steroidal Anti-inflammatory drugs) such as ibuprofen, naproxen, and diclofenac.
As Gabapentin V Pregabalin belongs to the same class of medicine, they have similarities between them.
- They work with the mechanism, which makes them having almost similar effectiveness.
- Both of them may cause abuse, that’s why they were declared from 1 April 2019 as a schedule 3 controlled drugs under the Misuse of Drugs Regulations 2001, and Class C of the Misuse of Drugs Act 1971.
- Similar side effects like dizziness, drowsiness, incoordination, memory problems, tremors, and blurred vision were caused by both drugs.
- Gabapentin V Pregabalin has shown withdrawal side effects on sudden stopping, both of them must be decreased gradually.
gabapantin v pregabalin
Abstract:
Gabapentin V Pregabalin has shown almost similar effectiveness, but Pregabalin outweighed gabapentin in a number of taken pills, cost-effectiveness, faster onset of action, tolerance, and fewer interactions.
- So if your doctor prescribed Pregabalin for your medical condition, make sure to inform your doctor about the following conditions before consuming the drug:
- Lung problems
- Mood changes like depression, or suicidal thoughts
- Heart problems
- Bleeding disorder
- Kidney problems
- diabetes, unless you are taking it for the neuropathic pain caused by diabetes
- Severe allergic reactions to Pregabalin or any other
- Pregabalin should not be used in patients younger than 18 years old for the treatment of pain caused by several reasons including fibromyalgia, diabetes, herpes zoster, or spinal cord injury
- It is not also approved for use by patients younger than 1-month-old for the treatment of seizures
- If you become pregnant, don’t start nor stop taking Pregabalin without the advice of your doctor, as seizure control during pregnancy is highly important
- Pregabalin may affect the fertility of men, as it can decrease the number of sperms
It also showed birth defects in the offsprings of males using Pregabalin as the animal studies showed
Always confirm with your health care provider the information you read on any medical article to make sure this information is convenient for your medical condition.
How long does it take for Pregabalin to work
Table of Contents
How long does it take for Pregabalin to work?
Pregabalin, this relatively new drug first stated in 2004 with Pfizer on the regulatory status of it, then obtained approval from the FDA (Food and Drug Administration) for the treatment for neuropathic pain on the last day of 2004.
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In 2007, FDA approved Pregabalin as the first drug for the management of fibromyalgia.
In 2012, it approved Pregabalin for controlling the neuropathic pain (damage or disease affecting a part of the sensory nervous system called the somatosensory system which causes pain in the nerves) caused by spinal cord injury.
And the successes continue when the FDA approved Pregabalin extended-release tablets for neuropathic pain conditions in 2017.
Pregabalin is also used for postherpetic neuralgia (severe pain sensed as stabbing or burning sensation caused by the irritating or damaged nerve), and as adjunctive therapy in treating partial-onset seizures.
And if we are going to talk about the successes of Pregabalin, we have to talk about how long does it take for Pregabalin to work?
Pregabalin is a fast-acting drug with high absorption after oral administration.
How to use Pregabalin?
Before taking any medication, you have to read the medication guide carefully.
If you have any inquiries, consult with your health care professional.
This is an orally available drug only.
It is not available as neither injectable nor rectal forms.
The dosage is based on the age and weight of the patient, medical condition, kidney function, and response to treatment.
If you are using the oral solution, use a special measuring device or spoon, don’t use a household spoon as it may give an incorrect dose which affects the effect of the drug.
You should start the medication with a low dose, then the physician can increase the dose as needed till reaches the lowest effective dose.
The dose must be taken at the same times every day to ensure a constant level of Pregabalin to make sure that the patient takes the most benefit of it.
To take the best on the drug, you have to understand how the drug works and how long does it take for Pregabalin to work?
How does Pregabalin work?
Pregabalin works by slowing down the impulses of the brain causing seizures, that’s how it works as an anti-epileptic drug and as an adjunctive drug to treat partial-onset seizures in adults and children who are 1 month and older.
It also affects the chemicals that send signals for pain through the nervous system, that’s how it works to treat pain caused by fibromyalgia, or the neuropathic pain caused by diabetes, or neuralgia that happens after the infection with herpes zoster, or the pain produced after a spinal cord injury.
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How long does it take for Pregabalin to work?
Pregabalin is a fast-acting drug; the peak of concentration after oral administration happens after 1.5 hours, it has greater than 90% bioavailability (the percentage available to the intended destination) no matter what the dose is.
Pregabalin can be taken with food as food doesn’t affect the total absorption of Pregabalin.
However, it was found that food affects and decreases the concentration in the plasma by 25%-30%.
And also increases the time to reach the peak of the drug to 3 hours approximately.
How long does it take for Pregabalin to work
Contraindications:
Before taking Pregabalin, make sure to inform your doctor if you suffer from any of the following conditions,
- Lung problems
- Depression
- Suicidal thoughts
- Mood disorder
- Heart problems
- Bleeding disorder
- Kidney problems
- Diabetes, except you, are taking it to manage the neuropathic pain associated with diabetes
- Any sort of abuse either drug or alcohol abuse
- Severe allergic reactions
Pregabalin is not approved for:
- seizures in patients younger than 1-month-old
- pain caused by fibromyalgia, diabetes, herpes zoster, or spinal cord injury in patients younger than 18 years old
Interactions:
Before taking Pregabalin, you must make sure that you are not taking a drug or food that interacts with it.
Drugs causing serious interactions and you have to use an alternative:
- benazepril
- captopril
- enalapril
- everolimus
- fosinopril
- imidapril
- lisinopril
- metoclopramide intranasal
- moexipril
- perindopril
- quinapril
- ramipril
- sirolimus
- temsirolimus
- trandolapril
Several drugs need close monitoring while being used with Pregabalin, some of them are:
- alprazolam
- amitriptyline
- amobarbital
- belladonna and opium
- benzhydrocodone/acetaminophen
- buspirone
- butabarbital
- carbinoxamine
- cenobamate
- cetirizine
- chloral hydrate
- chlordiazepoxide
- chlorpheniramine
- citalopram
- codeine
- diazepam
- doxepin
- duloxetine
- escitalopram
- eszopiclone
- ethanol
- fentanyl
- midazolam
And many others always tell your doctor about the medications you are taking before taking a new one.
Pregabalin-Alcohol interactions:
Alcohol can increase the side effects of Pregabalin especially those affecting the nervous system, like dizziness, drowsiness, and concentration problems.
We must not also forget about the absorption effect caused by food, so it is preferable to take Pregabalin away from meals.
Pregabalin has many advantages including effectiveness and how long does it take for Pregabalin to work?
Don’t forget to buy Pregabalin from trusted sources such as pharma stores to make sure about the drug you are buying, and also to get the best offers.
Pregabalin 75mg
Table of Contents
Pregabalin 75mg
Pregabalin 75mg is an antiepileptic drug, that is used to help control seizures (convulsions), It acts by slowing down the impulses in the brain that cause seizures.
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Pregabalin also affects chemicals in the brain that send pain signals across the central nervous system (CNS), but it will not cure epilepsy, it will only work to control seizures caused by it.
Pregabalin also is known for its good effect as an anticonvulsant and neuropathic pain agent.
Also, this medication is used to reduce pain caused by nerve damage due to diabetes or
shingles (herpes zoster), or a spinal cord injury.
It can be also used to treat fibromyalgia (muscle pain and stiffness).
Sometimes it is used “off-label” (not approved by FDA), to prevent migraine attacks. but your doctor can prescribe it to you if it seems to help.
Dosage Forms:
Pregabalin is available in many forms such as capsule, oral solution, or tablet (extended-release) with different available concentrations.
Proper Use
Do not take more of Pregabalin 75mg, and do not take it for a longer time than your doctor prescribed, to reduce the chance of side effects occurrence.
Read and follow the instructions carefully.
Pregabalin may be taken with or without food, if you take the tablet form it should be after an evening meal. Swallow it whole. Do not break or chew it.
Dosing:
The dose of this medicine will be different for each patient according to the medical condition.
For diabetic nerve pain:
- 50 mg 3 times a day for adults.
- Children’s dose must be determined by your doctor.
For partial-onset seizures:
- 150 mg per day given in 2 or 3 divided doses for adults.
- The usual dose is 2.5 mg/kg per day given in 2 or 3 divided doses for children one month of age and older weighing 30 kg or more.
- The usual dose is 3.5 mg/kg per day given in 3 divided doses for children one month of age and older weighing less than 30 kg.
For children younger than one month dose must be determined by your doctor.
- 75 mg 2 times a day for adults.
For children, check with your doctor.
For post herpetic neuralgia:
For oral dosage forms (capsules and solution):
- 75 to 150 mg 2 times a day, or 50 to 100 mg 3 times a day for adults.
For children, check with your doctor.
For oral dosage forms (extended-release tablets):
- 165 mg once a day for 1 week for adults.
For children, check with your doctor.
For spinal cord injury nerve pain:
For oral dosage forms (capsules and solution):
- 75 mg 2 times a day for adults.
For children, check with your doctor.
Consult your doctor:
This medicine is only taken as prescribed by your doctor, your doctor may recommend starting this medication at a low dose and gradually increase it, though in some cases that experience allergy or other side effects the doctor may reduce the dose gradually.
To get the most benefit from it use this medication regularly, at evenly spaced intervals.
Although it has many benefits, this medication may sometimes cause addiction.
You should follow your doctor’s instructions carefully to lower the risk of addiction.
Do not stop taking this medication suddenly without consulting your doctor as it may worsen your condition.
Precautions:
Your doctor must check the progress of treatment at regular visits, especially at the beginning of treatment. He may need to perform dose adjustments and to make sure this medicine is working properly. Blood analysis may be recommended to ensure safety from any unwanted effects.
Before taking Pregabalin 75mg, the following should be considered:
Allergies:
Tell your doctor if you are allergic to this medicine or any other medicines.
Any other allergies should be monitored such as allergies to food, dyes, animals, or preservatives.
Geriatric Patients:
Elderly patients are more susceptible to side effects such as dizziness, confusion, blurred vision, or clumsiness, which may require an adjustment in the dose.
Breastfeeding:
There are no adequate studies for determining infant risk when using this medication during breastfeeding. However, weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Other Medical Problems:
Make sure you tell your doctor if you have any of the following conditions:
- Alcohol or drug abuse.
- Angioedema (severe swelling).
- Congestive heart failure.
- Behavior changes.
- Bleeding disorder.
- History of Depression.
- Edema (body swelling or fluid retention).
- Heart rhythm problems.
- Lung or breathing problems (respiratory depression).
- Thrombocytopenia (low platelets in the blood).
- Kidney disease.
Safety of Pregabalin 75mg in Pregnancy:
Pregabalin use in pregnancy is best restricted to circumstances in which the risk-benefit ratio is favorable, (the risks of taking the medicine must be weighed against the good it will do).
Side Effects:
You should call your doctor immediately if any of the following side effects occur:
Less common
- Chest pain
- pale skin
- cough
- muscle aches, or weakness
- noisy breathing
- seizures
- tightness in the chest
Some other side effects may occur but do not need medical attention such as:
More common:
- Accidental injury
- blurred vision
- burning
- acute pain in the hands, feet, arms, or legs
- numbness
- tingling
- change in walking and balance
- headache
- loss of memory
- pain in the lower back or side
- painful or difficult urination
- poor insight and judgment
- problems with memory or speech
- rapid weight gain
- difficulty with speaking
- double vision
- dry mouth
- the sensation of pins and needles
Less common
- Anxiety
- feeling of fullness
- decrease or change in vision
- depression
- eye disorder
- false or unusual sense of well-being
- the general feeling of discomfort or illness
- increased hunger
- loss of appetite
- loss of bladder control
- loss of strength or energy
- nervousness
- nightmares
- pain
Storage:
Store Pregabalin in a closed container at room temperature, away from heat, moisture, and direct light.
Avoid freezing and keep out of reach of children.
Pregabalin for pain
Table of Contents
Pregabalin for pain
Pain, this sensation that ranges from just an annoying feeling to a debilitating feeling that can impede the life of the patient.
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Two kinds of pain are specifically very irritating, Neuropathy and Neuralgia.
Neuropathy is pain, numbness, tingling, swelling, or muscle weakness in different parts of the body, it usually occurs in the hands or feet, and worsens with time.
Neuralgia happens as a result of damage or irritation to the nerve which causes pain along the nerve pathway.
This pain is illustrated as burning, stabbing, sharp or shocking pain.
And we have the drug for both kinds of pain, and other kinds of pain also, Pregabalin for pain.
What is Pregabalin for pain?
Pregabalin got approval from the United States FDA (Food and Drug Administration) for the management of neuropathic pain caused by diabetes, spinal cord injury, and postherpetic neuralgia.
It is also got approval for the management of pain caused by fibromyalgia.
Pregabalin is used for chronic pain conditions not approved by FDA.
Pregabalin is not just for pain, it is also used as adjunctive therapy for partial-onset seizures.
Off-label uses like generalized anxiety disorder, social anxiety disorder, bipolar disorder, and insomnia.
How does Pregabalin for pain work?
Pregabalin for pain controls the chemicals which send the pain signals to nerves, to reduce how much you feel the pain you suffer from.
Dosage and administration:
Pregabalin for pain is found in many dosage forms and concentrations.
Capsules, extended-release tablets, and oral solutions.
It is not found as injectable forms.
In the management of peripheral neuropathic pain caused by diabetes:
Regular-release capsules
- Start the dose by 50 mg orally every 8 hours.
- It may be increased to 100 mg orally every 8 hours within 1 week according to the medical condition.
- Maximum dose: The dose should not exceed 300 mg per day.
pregabalin for pain
- Start the dose by 165 mg orally every 24 hours.
- It may be increased to 330 mg orally every 24 hours within 1 week according to the medical condition.
- Maximum dose: The dose should not exceed 330 mg per day.
In the management of postherpetic neuralgia:
Regular-release capsules
- Start the dose by 150-300 mg orally every 8-12 hours.
- It may be increased to 300 mg orally every 8-12 hours within 1 week according to the medical condition.
Extended-release tablets
- Start the dose by 165 mg orally every 24 hours.
- It may be increased to 330 mg orally every 24 hours within 1 week according to the medical condition.
- Maximum dose: 330 mg orally per day.
After 2-4 weeks, the patient may develop tolerance to the dose, so according to the doctor’s advice, the dose may be increased to 660 mg orally per day.
In the management of fibromyalgia (a condition that is characterized by pain as the main symptom of it):
Regular-release capsules and oral solutions are the only forms used for the management of fibromyalgia.
- Start the dose by 75 mg orally every 12 hours.
- It may be increased to 150 mg every 12 hours within 1 week according to the medical condition.
- Doses more than 450 mg per day are not recommended.
In the management of neuropathic pain caused by spinal cord injury:
Regular-release capsules and oral solutions are the only forms used for the management of neuropathic pain caused by spinal cord injury.
- Start the dose by 75 mg orally every 12 hours.
- It may be increased to 150 mg every 12 hours within 1 week according to the medical condition.
After 2-3 weeks, tolerance to the dose may occur; the doctor may advise increasing the dose to 600 mg per day.
- For patients suffering from any form of renal impairment, the doctor will change the dose according to the condition of the patient.
Warnings:
- Patients who suffer from hypersensitivity to Pregabalin for pain cannot take this drug at all.
- If you suffer from any kind of hypersensitivity, you must tell your doctor before taking pregabalin for pain.
- If you are taking thiazolidinedione antidiabetic drugs, peripheral edema and weight gain are highly susceptible to occur.
- Before consuming Pregabalin for pain, you must understand how you will react to the dizziness and somnolence caused by it before driving or performing any hazardous activities.
This may cause dangerous accidents.
- Symptoms like insomnia, nausea, headache, anxiety and diarrhea were stated after the sudden stop of Pregabalin for pain, even increased seizures with patients with seizures disorder.
Pregabalin for pain should not be stopped suddenly; it should be decreased gradually to avoid withdrawal symptoms.
Pregabalin for pain is potent, very effective, and fewer side effects causing drugs.
Consult with your doctor about the benefits and harms of Pregabalin for pain, and how effective it will be for your condition.
Pregabalin withdrawal symptoms
Table of Contents
Pregabalin withdrawal symptoms
Pregabalin, the ultimately famous drug, has so many uses, in so many different diseases.
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It is used in relieving nerve pain, some types of seizures, in addition to other anticonvulsants in the treatment of partial-onset seizures, neuropathic pain associated with diabetes or spinal cord injury, treatment of fibromyalgia, postherpetic neuralgia.
Pregabalin may be also used off-label for generalized anxiety disorder, hot flashes, restless leg syndrome (the urge to move your legs, it usually happens during the night), and social anxiety disorder.
But Pregabalin is not always that good, inappropriately taking Pregabalin may cause Pregabalin withdrawal symptoms when trying to stop it.
Always use Pregabalin exactly as described by your physician to take the ultimate benefit from it, and avoid the risks.
What is Pregabalin?
Pregabalin is a prescription need drug that is available in many dosage forms, capsules, solutions, and extended-release tablets.
All the dosage forms of Pregabalin are taken orally, not available as neither injection nor rectal forms.
How does it work?
- It is used in epilepsy by reducing the abnormal electrical activity in the brain.
- It also blocks pain by interfering with the messages of pain moving through the brain and down the spine that’s how it is used in nerve pain.
- In treating anxiety, Pregabalin stops the brain from releasing the chemicals responsible for the feeling of anxiety.
Pregabalin withdrawal symptoms
Dosage:
To avoid suffering from Pregabalin withdrawal symptoms, you must follow the directions of your physician strictly.
The dose is usually based on age, weight, and medical condition.
The dose may always be modified by your physician according to the response to treatment.
Pediatrics
For the treatment of partial-onset seizures:
Extended-release tablets are not used in pediatrics, with regular capsules and oral solutions only.
It is used in patients older than 1-month-old.
From 1 month – 17 years old:
Starting dose: 3.5 mg/kg/day taken orally in divided doses every 8 hours from 1 month – 4 years or every 8-12 hours for those older than 4 years old.
Maintenance dose: The dose may be increased weekly till it reaches 10 mg/kg/day.
Maximum dose: The dose not to exceed 600 mg/day.
Older than 17 years old:
Starting dose: 150 mg/day taken orally in divided doses every 8-12 hours.
Maintenance dose: The dose may be increased daily, but not to exceed 600 mg/day.
The use in children with renal impairment has not been studied.
Adults
For the treatment of the neuropathic pain caused by diabetes:
Regular-release capsules
Starting dose: 50 mg orally every 8 hours
Maintenance dose: The dose may be increased to 100 mg orally every 8 hours within 1 week if needed, but not to exceed 300 mg/day.
Extended-release tablets
Starting dose: 165 mg orally per day
Maintenance dose: the dose may be increased to 330 mg orally per day within 1 week, and it is the maximum dose allowed.
For the treatment of postherpetic neuralgia:
Regular-release tablets
Starting dose: 150-300 mg/day orally divided every 8-12 hours
Maintenance dose: The dose may be increased to 300 mg/day divided every 8-12 hours after 1 week if needed.
Extended-release tablets
Starting dose: 165 mg orally per day
Maintenance dose: The dose may be increased to 330 mg orally per day within 1 week, and it the maximum dose allowed
For the treatment of fibromyalgia:
It is treated using regular-release capsules and oral solution only.
Starting dose: 75 mg orally every 12 hours
Maintenance dose: The dose may be increased to 150 mg every 12 hours after 1 week if needed.
Maximum dose: 300-400 mg/day
For the treatment of partial-onset seizures:
It is used as adjunctive therapy using regular-release capsules and oral solution only.
Starting dose: 150 mg/day orally divided every 8-12 hours
Maximum dose: 600 mg/day
For the treatment of neuropathic pain caused by an injury to the spinal cord:
It is treated using regular-release capsules and oral solution only.
Starting dose: 75 mg orally every 12 hours
Maintenance dose: The dose may be increased to 300 mg/day orally divided every 12 hours
If tolerance occurred the dose may be increased to 600 mg/day divided every 12 hours
Stopping Pregabalin suddenly may cause withdrawal symptoms; the dose should be decreased gradually.
Your doctor will tapper the dose for you to avoid pregabalin withdrawal symptoms.
Pregabalin withdrawal symptoms:
- Seizures
- Dizziness
- Diarrhea
- Nausea
- Headaches
- Vomiting
- Irritability
- Sleeping troubles
- Nightmares
- Tingling feelings
Pregabalin withdrawal symptoms especially happen when taking high doses for a long time or abusing it.
If you feel any of the above symptoms, make sure to contact your doctor immediately.
Pregabalin is a very good and effective drug to be used for intended medical conditions, not for addictive reasons.
Don’t take Pregabalin without being prescribed by a physician and without a prescription or else you may suffer from Pregabalin withdrawal symptoms.
Get Pregabalin from trusted sources like pharma stores to avoid any unwanted effects.
Pregabalin anxiety
Table of Contents
Pregabalin anxiety
Anxiety is a normal feeling that haunts mankind; you can feel anxiety due to a job interview, the first day of school, or about what is going to happen in the future.
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This kind of anxiety can encourage you to accomplish what you want.
But this feeling may transform into a disorder, feelings become extreme, and last for longer than six months, interferes with your life, and cause a pause from accomplishments.
Generalized anxiety disorder is persistent worrying about several things, not one.
Pregabalin anxiety is one of the very effective drugs to control this disorder and return your life to normal.
It took 79% positive reviews on the treatment of generalized anxiety disorder.
According to a placebo-controlled trial published in the American Journal of Psychiatry in March 2003, Pregabalin anxiety was almost as effective as benzodiazepines.
It even overweighs benzodiazepines that it has fewer withdrawal symptoms.
Generalized anxiety disorder signs and symptoms:
- Fatigue
- Sleeping problems
- Tension
- Muscle aches
- Trembling
- Nervousness
- Sweating
- Nausea
- Diarrhea
- Irritability
The use of Pregabalin doesn’t stop on generalized anxiety disorder, it has many other uses.
It is used in:
- Peripheral neuropathic pain associated with diabetes.
- Postherpetic neuralgia.
- Partial onset seizures.
- Neuropathic pain after spinal cord injury.
Before taking this drug, make sure to inform your doctor about:
- Heart problems
- Kidney problems
- Breathing problems
- History of drug or alcohol use
Dosage and administration:
Pregabalin is available in oral dosage forms only.
Capsules with 25, 50, 75, 100, 150, 200, 225, and 300 mg concentrations
Oral solution with concentration of 20 mg/ ml
Extended-release tablets with 82.5, 165, and 330 mg concentrations
Dosage for Generalized anxiety disorder treatment:
The dose ranges between 150-600 mg daily divided every 8-12 hours.
Starting with 150 mg daily.
The dose may be increased according to the medical condition and response to treatment; it can be increased to 300 mg daily after 1 week.
Then to 450 mg after another week if needed.
Maximum dose: pregabalin 600 mg daily
For those who suffer from any kind of renal impairment, the dose should be adjusted according to the results of the lab tests.
- Take Pregabalin anxiety with or without food, it doesn’t matter.
- If you missed a dose, take it as soon as possible except it is the time for the next one, skip it and go back to the normal regimen.
Don’t double the dose.
- If you are using extended-release tablets, don’t split, crush nor chew the tablet.
- Take Pregabalin anxiety at the same time every day.
- It is preferable to be taken after the evening meal.
- If you missed the dose, take it till after the morning meal, don’t take it after that.
- If you overdosed, go to the nearest hospital or call an ambulance.
- Never stop taking Pregabalin anxiety suddenly, the dose should be decreased gradually, or else the patient will suffer from withdrawal symptoms.
- Seizures
- Dizziness
- Diarrhea
- Nausea
- Headaches
- Vomiting
- Irritability
- Sleeping problems
- Nightmares
- Tingling feeling
If you suffer from any of the above symptoms, consult with your doctor at once.
Always read the pamphlet (Patient information and instructions for use) of the drug before taking it.
Also, talk to your health care provider about any inquiries about the drug.
Side effects:
Common side effects:
- Dizziness
- Drowsiness
- Hands and feet swelling
- Concentrating troubles
- Increased appetite and weight gain
- Dry mouth
- Blurred vision
- Accidental injuries may occur
- Burning feeling in the limbs
- Incoordination
- Confusion
- Speaking difficulties
Less common side effects:
- Chest pain
- Cold sweats
- Pale skin
- Productive cough
- Breathing difficulties
- Muscle aches
- Seizures
This is not a full list of side effects; always talk to your doctor about any symptoms you are experiencing.
Warnings:
- Pregabalin anxiety may cause severe hypersensitivity, if you experience any signs of hives, itching, or swelling of lips and tongue, contact your doctor immediately.
- Don’t drive nor perform hazardous activities before you understand how the drug will affect you.
It causes dizziness and somnolence which may be very dangerous leading to accidents.
- If you have diabetes and noticed any weight gain, you may have to adjust your hypoglycemic drug.
- Dizziness and drowsiness may exacerbate when concomitantly used other drugs used to depress the CNS (Central nervous system).
- Patients with seizure disorders may suffer from increased seizures when they discontinued the drug rapidly.
- Monitor the patient for any signs of depression, suicidal thoughts, or behavior.
If you noticed any of these, contact your doctor at once.
- Using this drug with alcohol will increase the drowsiness caused by Pregabalin anxiety.
- Elders are more sensitive to side effects especially drowsiness, dizziness, unsteadiness, confusion, and shallow breathing.
Pregabalin anxiety is a very good drug that showed great efficacy in many disorders and diseases make sure to consult with your doctor if Pregabalin is suitable for your case especially if you are suffering from generalized anxiety disorder (GAD).
zopiclone tablets
Table of Contents
Zopiclone tablets
Zopiclone is one of the ideal hypnotics.
Hypnotics existed since the introduction of benzodiazepines which offer lots of advantages, they are effective and safe to some extent but the ideal hypnotics must have some characteristic like:
- induce and maintain sleep without any hangover effects over the next day.
- Safe use away from abuse (use a drug by a wrong way or for the wrong purpose) and dependence (adaptive state result from long term use of drug and result in withdrawal symptoms if drug stopped).
Zopiclone advantages
Zopiclone tablets is a new ideal hypnotic (sleeping pills) that belongs to a new chemical class, has a lot of advantages:
- Eliminated rapidly from the body; so no residual effects and no residual impairment of cognitive functions.
- No accumulation exists upon repeated administration.
- Its properties are not modified with kidney diseases or with the elderly.
- All clinical trials showed that zopiclone tablets 7.5mg are effective as hypnotic and can improve sleep variables in case of insomnia.
- Discontinuation of zopiclone tablets is not accompanied by rebound effect and relevant withdrawal symptoms.
- Craving studies failed to prove any dependence on zopiclone tablets.
- Side-effects are represented mainly by a bitter taste and dry mouth with a minimal incidence of CNS depressant effects.
- zopiclone tablets have no effect on respiratory functions, all the studies failed to prove any relation.
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Evaluation
Evaluation of the accumulated evidence of zopiclone tablets’ use from over 2.5 billion units dispensed in more than 30 countries indicates that it is effective with almost no side effects and an excellent alternative to benzodiazepines as a short-term treatment of insomnia.
zopiclone tablets
Tips about zopiclone use
- Don’t use zopiclone for more than 4 weeks; zopiclone is not an option for chronic insomnia( lasts for 3 nights a week for more than 3 months). The cause in these cases must be evaluated and treated first.
- Don’t drink any alcoholic beverages while using zopiclone, this may have an additive effect and leads to central nervous system depression.
- Don’t use zopiclone if you are younger than 18 years old.
- Tell your doctor if you have depression or any psychiatric illness or personality disorder.
- You shouldn’t use zopiclone tablets if you have any degree of respiratory failure or sleep apnea (episodes of breathing stopping or shallow breathing during sleeping).
- Use zopiclone tablets with caution if you suffer from any kidney or liver disease.
- Zopiclone tablets contain lactulose so if you have sugar intolerance avoid using them.
Drug-drug interaction:
There are some drugs that interact with zopiclone and change the way zopiclone tablets work some of these drugs:
- Other hypnotics (sleeping pills).
- Antiepileptics drugs like carbamazepine, phenobarbital, and phenytoin.
- Antipsychotics drugs (drugs used to treat psychosis).
- Some pain killers especially those that contain opioids like morphine, oxycodone, pethidine, codeine, and tramadol.
- Drugs used for the treatment of allergy-like chlorpheniramine, promethazine.
- Some antibiotics like rifampicin, clarithromycin, or erythromycin.
- Drugs to treat fungal infections like ketoconazole, itraconazole.
Zopiclone with alcohol
Alcohol consumption must be stopped during taking zopiclone tablets, as alcohol increases the effect of zopiclone be a bad manner and may be a difficulty in waking the next day.
Pregnancy and breast-feeding
If you are pregnant or have a plan to get pregnant talk with your doctor or pharmacist before taking zopiclone tablets.
If you already took it during pregnancy there is an increased risk of cleft lip and palate in the baby.
Taking zopiclone during the last six months of pregnancy can lead to abnormal fetal movement and fetal heart rate changes.
Do not take zopiclone during the last 3 months of pregnancy or during labor, the baby may have low body temperature, muscle weakness, breathing difficulties, difficulty feeding, and show withdrawal symptoms such as shaking after birth or agitation. The newborn should be closely monitored in these cases during the postnatal period.
Breast-feeding
Zopiclone can’t be used during breastfeeding or planning to breastfeed. This is because zopiclone can pass in the mother milk, talk to your doctor or pharmacist before taking any medicine in this situation.
Driving and using machines
Like other sleeping pills, Zopiclone tablets can cause the slowing of your normal mental function (central nervous system CNS depression). The risk of this impairment including driving ability is increased if:
- Within 12 hours of taking zopiclone and performing activities that require alertness
- A higher dose than recommended has been used.
- You are using other sleeping pills or other drugs that cause CNS depression or alcohol or drugs that increase the level of zopiclone tablets.
It is better to avoid driving or using heavy machinery or tools on the day after taking Zopiclone tablets 7.5mg especially if you are feeling drowsy or sleepy.
zopiclone tablets
Using valium for sleep
Table of Contents
Valium for sleep
Tranquilizers
are a group of drugs that are used to control anxiety, fear, tension, agitation, and any other mental problems.
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It can be either:
Minor tranquilizers: Anxiolytics (medication reduces anxiety).
Major tranquilizers: Antipsychotics (medication used to manage psychosis which affects how the brain functions).
Valium for sleep is one of the minor tranquilizers that are used for treating anxiety, alcohol withdrawal symptoms, and muscle spasms or stiffness.
Valium is used to treat seizures in combination with other medicines.
It works by controlling the hyperactivity of brain function to relieve severe stress and anxiety.
Valium must be taken under a doctor’s supervision as its dose changes according to the patient’s condition, age, and response to medication and the dose must never be increased by yourself as it may cause some serious side effects and overdose effect as we will discuss later in this article.
You can use valium for sleep and it should be individualized for better effects and the least side effects.
Usual daily doses:
Anxiety: 2mg to 10 mg from 2 to 4 times daily according to the condition.
Alcohol withdrawal: 10 mg 3 to 4 times for the first day then reduced to 5 mg 3 to 4 times daily.
Muscle spasms or stiffness: 2 to 10 mg 3 to 4 times daily.
Elder patients: 2 mg to 2.5 mg, 1 or 2 times daily the can be increased gradually as needed.
Dosage modifications:
if you want to use valium for sleep, please take care if you are suffering from:
Renal impairment: No modification is needed unless for prolonged treatment decrease in dose is recommended.
Hepatic impairment: 50% of the dose should be given only.
You must tell your doctor if you suffer from any of the following medical conditions before you start taking Valium for sleep as they may interfere with the drug:
-
Myasthenia gravis (a disorder of muscle weakness).
-
Severe breathing problems.
-
Sleep apnoea (stop breathing during sleep for short time).
-
Narrow-angle glaucoma.
-
Uncontrolled open-angle glaucoma.
-
Severe liver diseases.
-
Allergy to it.
-
Drug or Alcohol addiction.
-
Any kind of depression including (mood changes or suicidal thoughts).
-
Seizures unless you are taking it for a seizure disorder.
Valium for sleep is a long-acting medication compared to other drugs with the same action; it takes from 30 to 56 hours to get out from the body.
Valium for sleep is very effective, potent, and has a fast onset of action but if it is misused it will easily lead to addiction.
Taking Valium for sleep for longer than 4-6 weeks and with a dose more than acceptable even with a doctor’s prescription will lead to addiction to the drug.
Symptoms of Valium addiction:
- Feeling the need to have more pills to reach the desired effect.
- Craving for the drug before the time for the next dose.
- Become isolated from family and friends.
- Continuation in using the drug although has caused me many problems.
- Loss of interest in any activities or work.
- Ignoring the must-do things.
Even though you must not stop the drug from your own, Valium can cause very serious withdrawal symptoms that may lead to coma and even death.
Valium should be reduced gradually under the supervision of a doctor.
“Taking up to 60 tablets per day was not enough anymore to reach euphoria they were barely enough to reach somehow normal”
Valium is more likely to be used for those who struggle with the daily stress which affects their sleeping quality, it gives them calmness and euphoria especially with high doses, and those who are most vulnerable to addiction.
“Valium was making me not caring for the world anymore even if the house got on fire, I would say so what?!”
Overdosing is highly dangerous as it may lead to:
- Bluish lips.
- Double vision.
- Difficulty breathing.
- General weakness.
- Difficulty in coordination.
“Benzodiazepines (tranquilizers like Valium and Xanax) and opioids (it is a class of drugs that include illegal heroin, synthetic opioids such as fentanyl, and pain relievers legally available by a prescription like oxycodone, hydrocodone, codeine, morphine, and many others) strengthen each other giving higher effects of both of them but they can also cause death.”
– Dr. Michael Kelley, NPR, 2014
Valium may also counteract with some food like grapefruit, consuming large amounts of grapefruit or grapefruit juice strengthen the effects of Valium and can cause serious side effects.
Side effects:
- Severe allergic reaction.
- Hives (Urticaria).
- Difficulty breathing.
- Swelling of face, lips, tongue, and throat.
- Severe drowsiness or dizziness.
- Mood or behavior changes.
- Anxiety, depression, or worsening of both of them.
- Suicidal thoughts.
- Sleeping problems.
In 2011, 14.7 million prescriptions of Valium were written to patients.
Abuse of Valium was first noticed in 2013 as 1.2 million persons were reported to have abused Valium.
Addiction rehab centers are always there for those who fall into addiction with the help of very good and specialized doctors and psychiatrists.
valium for sleep reviews
Viagra for sale online
Table of Contents
Viagra for sale online
“Viagra for sale”, is that what you are searching for? You have reached the right destination. Pharmastores, easy and quick access to your drugs.
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Nowadays erectile dysfunction is a very common case. Viagra is a drug used to treat erectile dysfunction, let’s go through what’s Viagra, what is it used for, and other commonly asked questions.
Erectile dysfunction
Erectile dysfunction (ED) is defined as the inability to get and maintain an erection sufficient to have sexual intercourse.
Origin can be medical as the result of a medical condition affecting the blood supply of the penis and/or nerves. It also can be psychological due to stress.
Some recreational drugs, smoking, and alcohol can also cause erectile dysfunction.
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Viagra for sale in the UK
Pharmastores, trusted site to get your drug.
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What is Viagra?
Viagra is the brand name of sildenafil. Sildenafil is used for the treatment of erectile dysfunction. It belongs to a class of drugs called PDE5 inhibitors.
How does Viagra work?
PDE5 inhibitors work by inhibiting the degradative action of the PDE5 enzyme (phosphodiesterase type 5), which plays an important role in regulating blood flow to the penis.
Viagra works by increasing blood flow into the spongy-like tissue (the penis). This makes it easier to have and maintain a firm erection.
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What if you drink alcohol while taking Viagra?
It’s heavily advised not to combine alcohol with Viagra. Viagra lowers your blood pressure, as does alcohol, so you may experience unwanted side effects. These include:
- Dizziness
- Headache
- Heart palpitations
- Fainting
In another perspective, drinking alcohol has a negative impact on getting an erection. Therefore alcohol directly interferes with the Viagra pharmacological effect.
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How long does Viagra take to work?
Viagra is taken orally and absorbed quickly by the bloodstream.
Usually, it starts to work within half an hour.
It’s preferred to take Viagra on a relatively empty stomach about one hour before having sex as heavy meals may delay its action.
How long does the Viagra effect last?
Generally, everyone metabolizes medications differently. However,
Most people will feel the strongest effects of the drug for three to four hours.
Small amounts of Viagra could remain in your body for up to 20 hours.
What is the recommended dose of Viagra?
Viagra or sildenafil is available in several different doses. Available doses are 25mg, 50 mg, and 100 mg.
Generally, a dose of 50 mg is recommended for men with mild to moderate erectile dysfunction. However, your doctor will advise you with a suitable dose depending on the severity of your erectile dysfunction symptoms.
What can you do to have a good erection other than taking viagra?
- Eat healthy food.
- Do some exercise.
- Quit smoking.
- Manage your stress.
If you’re considering taking Viagra:
- Talk to your doctor and discuss if it’s suitable for you or not.
- Tell your doctor about your health condition.
- Tell your doctor about all the medications you take, including prescription drugs, nonprescription drugs, and herbal medicines.
Having good sexual health is a very important issue to maintain a good life, don’t hesitate to consult your family doctor about any problems you have.
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