Tag: diazepam
Does diazepam lower blood pressure
Does diazepam lower blood pressure?
Does diazepam lower blood pressure is an important question, you will find the answer by reading this topic.
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What is blood pressure?
Blood pressure is the pressure force blood in the circulatory system to deliver nutrient and oxygen to tissues and organs, not only that role but to remove toxic waste products pf metabolism including carbon dioxide that exhale with every breath and toxin that clear through liver and kidney.
What is the normal range of blood pressure?
The normal blood pressure range should be less than 120 systolic pressure, 80 diastolic pressure, regardless of your age you need to keep your pressure at this level.
How to measure blood pressure?
- A sphygmomanometer is a device we use to measure blood pressure, it consists of a rubber armband-the cuff that is inflated by hand, inflated until no blood can flow. Then the air is let out.
- The reading is expressed in terms of millimeters of mercury, abbreviated to mmHg.
How to keep your blood pressure under control and healthy?
There are few tips to keep your blood pressure under control without medication:
- Weight loss is one of the most effective lifestyle modifications to control your blood pressure.
- Physical activity and regular exercise: 30 minutes per day can lower blood pressure by about 5-8 mm Hg.
Example of aerobic exercise that helps you:
- Walking
- Cycling
- Swimming
- Jogging
- Dancing
- Eat a healthy diet: diet rich in fruits, vegetables, whole grains, and low-fat dairy products and skimps on saturated fat and cholesterol.
- Reduce sodium in your diet: small reduction in sodium in your diet has a great effect in reducing your elevated blood pressure.
- Limit alcohol intake
- Quit smoking: Quitting smoking can reduce your risk of heart disease and improve your overall health.
- Reduce your stress: avoiding stress triggers and make time to relax will help you.
- Regularly monitor your blood pressure and visit your doctor if you cannot control it.
- Cut back on caffeine: effect of caffeine on elevated blood pressure does not clear till now, talk to your doctor about the effect of caffeine on your blood pressure.
What is diazepam?
Diazepam: is a medicine of the benzodiazepines family, commonly used for treating the following condition:
- Anxiety disorder
- Muscle spasm
- Alcohol withdrawal symptom
- Insomnia
- Restless leg syndrome
- Seizures
How can you take diazepam?
You can take diazepam by:
- Mouth
- inserted to the rectum.
- Injected into muscle.
- Injected into a vein.
- Nasal spray
Warning and precautions:
- An allergic reaction may occur when using diazepam, this reaction includes swelling of lips, tongue, and face.
- Respiratory depression especially when used with opioids.
- Sedation: you must be cautioned about performing a task that requires mental alertness (e.g., driving, operating machinery).
- Hepatic impairment: oral tablet is contraindicated in patients with severe hepatic impairments.
- Renal impairment: Use with caution.
- Glaucoma
- Abuse, misuse may lead to physical dependence.
Side effect:
- Diarrhea
- Muscle weakness.
- Respiratory depression.
- Urinary retention.
- Blurred vision.
- Abdominal pain.
- Change in salivation.
Drug-drug interaction:
Many medications may affect the efficacy of diazepam if it is used concomitant with diazepam.
Effect of diazepam may decrease by:
- Tocilizumab
- Theophylline derivatives.
Drugs should be avoided in concomitant use with diazepam:
- Fusidic acid (systemic).
- Metronidazole (systemic).
Does diazepam lower blood pressure?
Does diazepam lower blood pressure is a good question, as it is known that benzodiazepine has a hypotensive effect.
What is hypotension?
It is a drop in blood pressure, may cause the following symptom:
- Clammy skin.
- Blurred vision.
Many studies have shown that there was a significant decrease in systolic blood pressure after the administration of diazepam.
But the mechanism is still not known.
One of these studies answered the question does diazepam lower blood pressure?
A total of 30 subjects were included in the analysis of this study, and Aim was to assess the effects of evening chronic administration of diazepam on 24-hour blood pressure and heart rate in healthy young adults.
By the end of the study, the results show that there was a significant reduction in systolic blood pressure, were observed in the morning hours.
Things must not do when you take diazepam:
- Do not drive or operate machinery until you know how diazepam affects you.
- Do not take diazepam for a longer time than your doctor has prescribed.
- Do not stop taking diazepam or lower the dose without first checking your doctor.
- Do not suddenly stop taking diazepam if you suffer from a seizure.
- Do not give diazepam to anyone else even if their symptoms seem like yours.
- Be careful if you are elderly, drinking alcohol, or taking other medications.
Diazepam and pregnancy
Diazepam and pregnancy
Diazepam and pregnancy is a very important topic, we will try here to illustrate the risk of using diazepam during pregnancy, and give you more information about it
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What is diazepam?
Diazepam is a benzodiazepine drug, used as an anti-anxiety medication, to treat muscle spasms and fits (seizure) in combination with other anti-seizure drugs. Diazepam and
Also, there is off-label use in treating insomnia, a symptom of alcohol withdrawal.
Diazepam is found in different forms: tablets, liquid, rectal gels, injection: intravenous injection, and intramuscular.
Precautions:
- Abuse, misuse, and addiction: the continued use of diazepam for several weeks may lead to physical dependence.
- Sedation and respiratory depression when concomitant use with opioids.
- The hepatic disorder is considered a contraindication for using diazepam.
- Renal impairment needs caution for use.
Adverse reactions:
- Drowsiness
- Hypotension
- Abdominal pain
- Diarrhea
- Agitation
- Dizziness
- Asthma
- Nasal congestion
- Pruritus
- Urinary tract infection
- Neutropenia
- Mydriasis
- Hyperkinetic muscle activity
- Cough
- Ataxia
- Skin rash
- Muscle weakness
- Urinary retention
- Incontinence ( inability to control urination or defecation)
- Change in salivation
- Fatigue
- Dysarthria
- Jaundice
- Thrombophlebitis
- Tissue necrosis
- Carpal tunnel syndrome
What should I need to monitor during the use of diazepam?
- Heart rate
- Respiratory rate
- Blood pressure
- Mental status
- Liver enzyme
- CBC
- Serum creatinine
- You shouldn’t use diazepam if you have an allergy to benzodiazepine (a pharmacological group that diazepam belongs to).
Will using another medication affect diazepam efficacy?
- Concomitant use of another medication may have a great effect on diazepam, that’s why there is a list of medication should be avoided during using diazepam
- Abametapir
- Azelastine
- Bromperidol
- Conivaptan
- Fusidic acid ( systemic)
- Metronidazole(systemic)
- Olanzapine
- Orphenadrine
- Thalidomide
- Oxomemazine
Another list of medications may decrease the diazepam effect
- Dabrafenib
- Deferasirox
- Enzalutamide
- Erdafitinib
- Ombitasvir
- Ritonavir
- Theophylline derivatives
- Tocilizumab
List of medication increase diazepam effect:
- Conivaptan
- Bromopride
- Disulfiram
- Metronidazole
- Ritonavir
- Magnesium sulfate
- Melatonin
Special population:
- Elderly: The effect of diazepam is extended in an elderly patient, that’s required the use of the smallest effective dose and increased gradually as tolerated to avoid undesirable side effects.
- Obese: benzodiazepine in an obese patient may have prolonged action.
- Psychotic: not recommended in place of appropriate therapy.
- Pediatric: can be used in a specified dose.
- Breastfeeding: sedation and weight loss have been observed in infants exposed to diazepam through breast milk.
Diazepam and pregnancy
Although the safety of diazepam in pregnant women hasn’t been established, It should not be used in the first and third trimesters.
Floppy infant syndrome can occur if the product is administered during the late phase of pregnancy or labor at high doses.
Floppy infant syndrome is hypotonia (low muscle tone), sluggishness, and trouble latching on feed.
Teratogenic effects have been observed however there’s a need for additional studies
- Infant risk may include :
- Premature birth
- Low birth weight
- Hypoglycemia
- Respiratory problem
- Smaller head circumference
- Cleft lip
- Cleft palate
Any pregnant woman should talk to her healthcare provider before stopping or changing the dose. A sudden stop of diazepam may cause withdrawal symptoms, which may include:
- Headache
- Nausea
- Vomiting
- Stomach pain
- Cramps
- Tremors
- Increase blood pressure
- Increase heart rate
- Confusion
- Seizure
- Mood swings
- Depression
- Panic attack
- Rebound anxiety
- Drug craving
Gradually decreasing the dose till stopping diazepam under medical supervision is a good way to minimize any adverse effect that may occur
What is the withdrawal symptom in the infant after delivery?
After delivery, withdrawal symptoms may occur spontaneously or after several days, that symptoms may include :
- Breathing problem
- Jitteriness
- Excessive crying
- Trouble maintaining body temperature
- Floppy infant syndrome
- Sleeping problem
- Seizures
- Stuffy nose
- Sneezing
- Poor feeding
- Vomiting
- Diarrhea
- Dehydration
- Sweating
- Yawing
All these symptoms may be required to stay in hospital for monitoring, and by several weeks all symptoms disappear.
After all that, there is no data said that there is a long term effect on behavior by using diazepam during pregnancy
Diazepam and breastfeeding
It is not recommended to take diazepam during breastfeeding, as diazepam and its metabolites are present in breast milk. Due to the long half-life of diazepam, it accumulates in the breastfed infant. Infants should be closely monitored for drowsiness, decreased feeding, and poor weight gain.
Overdose of diazepam
If you accidentally take an overdose you need to call your doctor immediately.
Sign and symptoms of overdose
- poor coordination or trouble speaking
- feeling sleepy
- a slow or irregular heartbeat
- uncontrolled eye movements
- muscle weakness
- feeling overexcited
to make sure it is safe for you to start diazepam, talk to your health care provider if you have any of the following condition
- have an allergic reaction to diazepam
- muscle weakness conditions like myasthenia gravis
- breathing problem conditions like sleep apnea
- having depression or other behavioral condition
- have a problem related to alcohol or drug abuse
- age over 65
- have general anesthesia for an operation
- severe liver disease
- have kidney problem
- have arteriosclerosis
- have narrow-angle glaucoma
- seizures
Diazepam and Propranolol
Diazepam and Propranolol
Diazepam and propranolol are two different drugs that can be used for the same purpose which is treating anxiety.
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They are also used for other reasons.
Diazepam and propranolol can be used individually and in combination with each other.
Using them in combination increases the effect of diazepam being more effective in treating anxiety than diazepam on its own.
So, let’s get to know diazepam and propranolol.
Family, uses, and indications:
Propranolol is from a drug family called beta-blockers, which are usually used to treat hypertension (high blood pressure) and heart problems, and used off-label in treating anxiety, and diazepam belongs to a drug family called benzodiazepines, a family used to treat anxiety.
So, diazepam and propranolol are common in treating anxiety.
Propranolol and beta-blockers are used for the physical symptoms (symptoms occurring to the body) of anxiety-like fast heart rate, chest tightness, and sweating, they are not related to the psychological and emotional symptoms like worrying and stress feeling.
Diazepam and benzodiazepines cause sedation, but they can be taken during acute bouts of anxiety and panic attacks, relieving stress and worry.
How do diazepam and propranolol work?
Beta-blockers and propranolol block certain neurotransmitters called epinephrine and norepinephrine, which help in dilating blood vessels, and decreasing heart rate and blood pressure.
Benzodiazepines and diazepam work by enhancing the activity of certain neurotransmitters called GABA (Gama Amino-butyric acid) that produces a calming effect on the brain and nerves.
Side effects:
There are common side effects between diazepam and propranolol and uncommon ones.
Common side effects are diarrhea, rash, blurred vision, diplopia (double vision), insomnia (sleeping problem), muscle spasms and stiffness, and fatigue.
The uncommon side effects of propranolol different from diazepam are stomach cramps, nausea, vomiting, disorientation (loss of sense of direction), hair loss, weakness, sexual dysfunction.
Uncommon side effects of diazepam different from propranolol are drowsiness, euphoria (intense excitement and happiness), loss of balance, excitability due to paradoxical reactions, rage, confusion, and speech problems.
Withdrawal symptoms:
Diazepam and propranolol are common in another aspect, both of them should not be stopped suddenly, they must be withdrawn gradually or they may cause withdrawal symptoms.
Propranolol may cause withdrawal symptoms like heart attacks, worsened chest pain (angina), serious abnormal rhythm of the heart, or even sudden death.
Diazepam may also cause withdrawal symptoms, especially after long use, like insomnia, headaches, nausea, vomiting, lightheadedness, sweating, anxiety, fatigue, and seizures.
Warning: Diazepam may cause dependency and addiction, especially when using high doses for a long duration, also a trigger effect when you have a history of abuse or addiction to any drugs or alcohol.
Drug-drug interactions with diazepam and propranolol:
Propranolol interactions
- Propranolol with thioridazine or chlorpromazine may cause a decrease in blood pressure (hypotension) and abnormal rhythms of the heart because they interfere with the elimination of propranolol and increase the concentration of the drug in the blood.
- Combination with clonidine may cause a dangerous increase in blood pressure, that’s why close monitoring should be done after the starting or stopping of the concurrent use of clonidine and propranolol, as stopping them suddenly may also cause an increase in blood pressure.
- Phenobarbital and similarities increase the breaking and blood levels of propranolol which may reduce the effectiveness of the drug.
- Aspirin and NSAIDs (Non-steroidal anti-inflammatory drugs) may reduce the effects of propranolol by reducing the effects of prostaglandins that help in controlling the blood pressure.
- Propranolol elongates hypoglycemia (low blood sugar) and masks the symptoms in diabetic patients.
Diazepam interactions
- CNS (Central Nervous System) depressants that cause sedation to increase the sedative effects of diazepam, alcohol can cause the same effects.
- Drugs that inhibit the liver enzymes responsible for eliminating diazepam and causing prolongation of their effects, their doses may be decreased if concomitantly used like:
- cimetidine
- ketoconazole
- itraconazole
- omeprazole
- erythromycin
- clarithromycin
- darunavir
- fluvoxamine
- fluoxetine
- On the opposite, drugs increasing the elimination of diazepam by liver enzymes and decreasing the levels of diazepam, like carbamazepine, rifampin, and St. John’s wort.
Warnings and precautions:
- Before taking propranolol, you have to tell your doctor if you have:
- Asthma
- Bradycardia (very slow heartbeats)
- Sick sinus syndrome (a serious heart condition) or another heart problem called AV block (a condition that needs a pacemaker)
- Muscle disorder
- Breathing problems like bronchitis or emphysema
- Diabetes or low blood pressure
- Congestive heart failure
- Depression
- Liver or kidney problems
- A thyroid disorder
- A condition caused by a tumor of the adrenal gland called pheochromocytoma
- Raynaud’s syndrome (circulation problem)
Before taking diazepam, you have to tell your doctor if you have:
- Myasthenia gravis (a condition causing weakness of muscles)
- A severe breathing problem
- Sleep apnea (breathing stops for a short period during sleep)
- Eye problems like narrow-angle glaucoma or uncontrolled open-angle glaucoma
- Severe liver diseases
The combination between diazepam and propranolol may be effective due to increasing the medical effects of diazepam but also should be taken with care as the side effects also may increase.
Omeprazole and Diazepam
Omeprazole and Diazepam
Omeprazole and diazepam are two completely different drugs, with different uses, and mechanisms of action.
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So, what happens when combining omeprazole and diazepam?
First, we have to understand the nature of both drugs.
Omeprazole is a proton pump inhibitor drug, a family of drugs that help to reduce the production of acid in the stomach.
Acid is responsible for ulcers in the esophagus, stomach, and duodenum.
Decreasing the acid prevents the formation of ulcers, and if they are already formed, they help in their healing.
Omeprazole also helps in relieving acid reflux, heartburn, swallowing difficulties, and persistent cough.
It is available in many dosage forms, packets, suspension, delayed-release tablets, delayed-release capsules, and orally disintegrating tablets, with many concentrations.
It takes from 1 to 4 days to work and has a full effect.
Omeprazole can be used as an over-the-counter drug, that’s why you have to read the package instructions carefully, and don’t take it for more than 14 days unless you reviewed the case with a doctor.
It can be taken concomitantly with antacids like sucralfate.
Side effects:
Common side effects
- Headache
- Abdominal pain
- Diarrhea
- Nausea
- Vomiting
- Flatulence
- Dizziness
- Upper respiratory infection
- Acid regurgitation
- Constipation
- Rash
- Cough
Less common side effects
- Fracture of bone because of it increases the chance of osteoporosis
- Hepatotoxicity
- Agranulocytosis (life-threatening medical condition concluding low white blood cells)
- Anorexia (eating disorder related to a mental health condition)
- Gastric polyps (abnormal growth of the stomach lining)
- Hip fracture
- Alopecia (hair loss)
- Atrophic gastritis (inflammation of the gastric mucosa)
- Interstitial nephritis (kidney problem)
- Pancreatitis (inflammation in the pancreas)
- Rhabdomyolysis (a serious medical condition caused by muscle injury)
- Metallic taste
- Abnormal dreams
- Toxic epidermal necrolysis (a very serious and rare skin condition)
Warnings:
- Omeprazole may cause a serious hypersensitivity reaction, take care of any signs of hives, blisters, and swelling of the face, lips, and tongue.
- Omeprazole and proton pump inhibitors family may cause a serious condition of diarrhea called CDAD
- If you are suffering from liver disease, you will need to decrease the dosage.
- Omeprazole was proven to cause carcinoid tumors with increased doses in rats, but this condition was not confirmed in humans.
- It may decrease the activity of Clopidogrel (a drug used to prevent blood clots).
Pregnancy:
While the woman is pregnant, it is always better to treat any conditions like indigestion without using drugs.
Indigestion can be managed by eating smaller meals and avoid spicy and fatty meals.
However, omeprazole can be taken safely in pregnancy.
Breastfeeding:
Omeprazole is known to be secreted in mother’s milk in small amounts, however, it is safe to be taken while breastfeeding.
Back to the relation between omeprazole and diazepam, let’s now talk about diazepam.
Diazepam is a member of the benzodiazepines family.
Benzodiazepines are drugs slowing down the messages between the brain and body, they are also minor tranquilizers.
Diazepam is used in treating anxiety, alcohol withdrawal symptoms, seizures, relaxation of muscle spasms, and to induce sedation before surgeries and dental procedures.
It is available in many dosage forms, tablets, oral solutions, rectal gels, injectable solutions, and intramuscular devices.
Side effects:
Happens in 1 – 10% of patients
- Ataxia (disorder causing symptoms similar to those when you are drunk, problems with balance, speech, and coordination)
- Euphoria (extensive excitement and happiness)
- Incoordination
- Somnolence (drowsiness and sleepiness)
- Rash
- Diarrhea
Common side effects
- Hypotension
- Fatigue
- Muscle weakness
- Respiratory depression
- Urinary retention
- Depression
- Incontinence (inability to control urination and defecation)
- Blurred vision
- Headache
- Changes in salivation
- Muscles responsible for speech are damaged
Warnings:
Opioids are a group of drugs widely known for pain-relieving, like morphine which is naturally produced from the poppy plant, and fentanyl which is synthesized in a laboratory.
A combination of diazepam and opioids is very dangerous, that may result in profound sedation, respiratory depression, coma, and death.
- FDA (Food and drug administration) addressed that benzodiazepines may cause serious addiction, abuse, and misuse.
These may result in overdosing and death.
- Diazepam should not be stopped suddenly, if so, irritating and maybe even life-threatening withdrawal symptoms.
Withdrawal symptoms:
- Tremors
- Anxiety
- Confusion
- Seizures
The withdrawal period may last from 3 to 4 weeks.
- Diazepam using may disable your ability to drive and to perform hazardous activities, you should not do any of them before understanding how your body will react to the drug.
Pregnancy:
Diazepam pregnancy category: D
It should only be used in life-threatening conditions when no other alternative is available.
Breastfeeding:
Diazepam is secreted in human milk and may cause harm to the baby.
It should not be used during lactation, alternative drugs or feeding options may be recommended.
Omeprazole and diazepam should be used together with extreme care, omeprazole may increase the concentration of diazepam in blood, which may cause an increase in the side effects caused by diazepam.
Using them together may need a dose adjustment or monitoring by your medical health provider.
A combination of drugs may be dangerous, need close monitoring, or mildly interacted, always tell your doctor about the drugs you are taking before taking another one.
Diazepam and Asthma
Diazepam and Asthma
Diazepam and asthma can be discussed from two points of view,
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one is the use of Diazepam in respiratory failure associated with Status Asthmaticus who need mechanical ventilation, the other point is that Diazepam and Asthma should be used with extreme caution as it may lead to apnea or cardiac arrest.
But first, before the discussion of the relationship between diazepam and asthma, we have to know about diazepam and asthma.
Asthma is a medical condition where the airways are narrow, swell, and produce extra mucus, which can cause breathing difficulties, triggering cough, and wheezing when breathing.
For some patients, Asthma may be a minor problem, and for others, it is a major problem, which interferes with the quality of life, and can lead to asthmatic attacks which can be life-threatening.
Asthma is a chronic medical condition that has no cure but can be controlled.
Symptoms:
Symptoms of Asthma differ from one patient to another.
They include,
- Short or shallow breathing
- Tightness or pain in the chest
- Wheezing with exhalation, which is especially common in children
- Shortness of breath, coughing, and wheezing can also interfere with your sleeping
- Cold and Flu worsens the coughing and wheezing attacks
Signs of worsened Asthma:
- More frequent signs and symptoms
- Breathing difficulties increase
- The use of a quick-relief inhaler is more frequent
Factors worsening Asthma:
- It may be worsened by exercise
- It may be increased by chemical fumes, gases, and dust
- It also may be increased by allergens like pollen grains, mold spores, cockroach wastes, and others
Asthma attacks can be deadly, always monitor your symptoms with your doctor to control the symptoms and avoid the worsening of them.
How about Diazepam?
Diazepam is one of the benzodiazepines family, that works by inducing the effect of some neurotransmitters in the brain which produces a calming effect.
It is used in treating anxiety disorders, alcohol withdrawal symptoms, muscle spasms and stiffness, and as adjunctive therapy in treating seizures.
It is also used in inducing sedation before having surgery or having an endoscopy.
According to our first point of view about Diazepam and Asthma, Diazepam is used in inducing sedation in the ICU (Intensive Care Unit) to put the patient on mechanical ventilation to treat the respiratory failure associated with Status Asthmaticus to help to restore ventilation and gas exchange.
Diazepam is given by a dosage of 0.2 – 0.3 mg/Kg every 1 – 3 hours.
Dosing and administration:
Diazepam is available in many dosage forms, tablets, oral solutions, rectal gels, injectable solutions, and intramuscular devices.
Oral solutions are only taken with the calibrated dropper coming with the drug, or with any special measuring device.
Don’t use the household spoons to avoid incorrect dosing.
If you are going to use the injectable methods, inspect the product for particulates, and for change in color before administration.
If you are using the intravenous injection, ensure there are facilities to assist respiration if needed.
Don’t use the small veins found in the hand or wrist, and inject it slowly for 1 minute for each 5 mg.
Storage:
When using the oral solution, throw the bottle after 90 days of opening.
Store it away from light.
Store it at a temperature between 68 and 77 degrees F.
Contraindications and precautions:
- If you experienced extreme hypersensitivity to diazepam or other benzodiazepines.
- When using the intravenous method, inject it very slowly, and don’t use small veins, to avoid venous thrombosis (a blood clot in the vein), phlebitis (inflammation of the vein), and irritation at the site of injection.
- Diazepam may cause depression and suicidal thoughts, if they already exist, they may be worsened by the use of diazepam, and so, you have to be monitored carefully if you are going to use diazepam or other anti-epileptic drugs.
- The doctor prescribes the smallest dose effective to reduce the risk of side effects and overdose.
- Activities requiring mental alertness should not be done when using drugs causing CNS (Central Nervous System) depression without understanding the effect of the drug on your mental alertness, activities like operating heavy machinery, and driving, as this may lead to bad falls, and dangerous accidents.
- Using diazepam with other CNS depressants such as opioids may cause severe side effects like profound sedation (unconsciousness where the patient can’t be awakened easily), respiratory depression, coma, and death.
The other point of view of Diazepam and Asthma, diazepam is not used in patients with severe respiratory problems and sleep apnea (Inability to breathe while sleeping for a short period), and used with extreme caution in patients with asthma, pneumonia, or neurologic damage as they may cause apnea (stop of breathing) or cardiac arrest.
So, diazepam is a life-saving drug when used when mechanical ventilation is needed to induce sedation in case of very severe status asthmaticus, and if it is going to be used with asthmatic patients, it should be used with extreme caution as it may cause severe side effects.
Diazepam and Tramadol
Diazepam and Tramadol
Mixing diazepam and tramadol may lead to serious side effects, but first, we should know about diazepam and tramadol individually.
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What is tramadol?
Tramadol is a synthetic opioid analgesic that has narcotic-like painkiller action, used in treating moderate to severe pain cases in adults.
Warnings:
- Seizures were reported in patients using tramadol.
They happen more frequently if you are taking higher doses more than recommended if you already suffer from a seizure disorder, or with those taking antidepressants or opioid medications.
- If you have ever suffered from suicidal thoughts, behaviors, or if you are susceptible to addiction or abuse, you shouldn’t use tramadol in these cases.
- You should not also use it if you have severe breathing problems, stomach or intestines blockage.
Before taking tramadol, you should not take it if:
- You are allergic to tramadol
- You have breathing problems or severe asthma
- You have obstructive stomach or bowel (like paralytic ileus)
- You are consuming alcohol, using sedatives, tranquilizers, and narcotic medications
- You are taking a drug from the group MAO inhibitors or took it in the past 14 days (like isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine)
Tramadol is not used in children younger than 12 years old.
It is not given to any patient younger than 18 years old who removed the tonsils or adenoids recently.
Don’t give tramadol to patients between 12 and 18 years old who have breathing problems.
Tramadol and pregnancy are contraindicated.
It may cause withdrawal side effects that may even lead to death.
It was noticed that babies nursing to mothers taking tramadol signs of severe drowsiness and shallow breathing, talk to your doctor about alternative drugs or feeding options.
To make sure tramadol is suitable for your condition, you have to tell your doctor if you have ever had:
- liver problems
- Kidney problems
- Breathing problems like sleep apnea (stop of breathing for a short period while sleeping)
- urination problems
- Gallbladder, pancreas, or thyroid problems
- Stomach problems
- Mental problems
- Suicidal thoughts or behaviors
Mixing alcohol with tramadol cause serious side effects leading to death.
Don’t perform hazardous activities or operate heavy machines while taking tramadol as drowsiness may cause serious falls or accidents.
What is diazepam?
Diazepam is a benzodiazepine drug, used in treating anxiety disorders, alcohol withdrawal symptoms, muscle spasms, and stiffness, and as adjunctive therapy in treating seizures.
It is also used to help you get in relaxation before any surgical or dental procedures.
Diazepam is available in many dosage forms, tablets, oral solutions, rectal gels, injectable solutions, and intramuscular devices.
Warnings:
- Diazepam may cause slow or shallow breathing, especially if used with an opioid medication, alcohol, or other drugs that may cause slow or shallow breathing
- Unfortunately, diazepam may cause addiction, overdose, which may lead to death, use this drug exactly as the doctor prescribed to avoid these side effects
- Diazepam may cause a severe allergic reaction, including swelling of face, lips, and tongue, don’t use it if you have ever experienced allergy with diazepam or other benzodiazepines
- Efficacy and safety have not been established in children younger than 6 months, so they should not be used at that age
Before taking diazepam, you have to tell your doctor if you have ever had:
- Myasthenia gravis (a medical condition causing weakened and tired muscles)
- Severe breathing problems
- Sleep apnea (stop of breathing for a short period while sleeping)
- Narrow-angle glaucoma
- Uncontrolled open-angle glaucoma
- Severe liver problems
Having seizures during pregnancy may harm both mother and baby, but as well diazepam should not be used started not stopped during pregnancy without the doctor’s advice.
It may cause dependence if was used during pregnancy, which may cause deadly withdrawal symptoms in newborn babies.
Diazepam should not be used in breastfeeding mothers, talk to your doctor about alternative drugs or feeding options.
To make sure tramadol is suitable for your condition, you have to tell your doctor if you have ever had:
- Breathing problems
- Glaucoma
- Kidney problems
- Liver problems
- Seizures, unless you are taking it for the same reason
- An addiction to drugs or alcohol
- Depression
- Suicidal thoughts or behaviors
Diazepam and tramadol are CNS (Central Nervous System) depressants.
The combination of diazepam and tramadol abolished seizures, but the CNS depression caused by this combination is very severe.
Serious side effects caused by diazepam and tramadol combination include respiratory distress, coma, and death.
If the combination between them is conditional, dose adjustment or more frequent monitoring must be done to safely use both medications.
But using alternatives is more appropriate.
Consuming alcohol with diazepam and tramadol, or using unprescribed medications can be very dangerous if done without the supervision of your doctor.
Don’t alter the doses, frequency, or duration of use without consultation from your doctor.
Diazepam and tramadol may cause dizziness, drowsiness, concentration difficulties, and judgment, speed, and motor coordination impairment.
So, don’t combine diazepam and tramadol, as it may be really dangerous.
Using valium for sleep
Valium for sleep
Tranquilizers
are a group of drugs that are used to control anxiety, fear, tension, agitation, and any other mental problems.
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It can be either:
Minor tranquilizers: Anxiolytics (medication reduces anxiety).
Major tranquilizers: Antipsychotics (medication used to manage psychosis which affects how the brain functions).
Valium for sleep is one of the minor tranquilizers that are used for treating anxiety, alcohol withdrawal symptoms, and muscle spasms or stiffness.
Valium is used to treat seizures in combination with other medicines.
It works by controlling the hyperactivity of brain function to relieve severe stress and anxiety.
Valium must be taken under a doctor’s supervision as its dose changes according to the patient’s condition, age, and response to medication and the dose must never be increased by yourself as it may cause some serious side effects and overdose effect as we will discuss later in this article.
You can use valium for sleep and it should be individualized for better effects and the least side effects.
Usual daily doses:
Anxiety: 2mg to 10 mg from 2 to 4 times daily according to the condition.
Alcohol withdrawal: 10 mg 3 to 4 times for the first day then reduced to 5 mg 3 to 4 times daily.
Muscle spasms or stiffness: 2 to 10 mg 3 to 4 times daily.
Elder patients: 2 mg to 2.5 mg, 1 or 2 times daily the can be increased gradually as needed.
Dosage modifications:
if you want to use valium for sleep, please take care if you are suffering from:
Renal impairment: No modification is needed unless for prolonged treatment decrease in dose is recommended.
Hepatic impairment: 50% of the dose should be given only.
You must tell your doctor if you suffer from any of the following medical conditions before you start taking Valium for sleep as they may interfere with the drug:
-
Myasthenia gravis (a disorder of muscle weakness).
-
Severe breathing problems.
-
Sleep apnoea (stop breathing during sleep for short time).
-
Narrow-angle glaucoma.
-
Uncontrolled open-angle glaucoma.
-
Severe liver diseases.
-
Allergy to it.
-
Drug or Alcohol addiction.
-
Any kind of depression including (mood changes or suicidal thoughts).
-
Seizures unless you are taking it for a seizure disorder.
Valium for sleep is a long-acting medication compared to other drugs with the same action; it takes from 30 to 56 hours to get out from the body.
Valium for sleep is very effective, potent, and has a fast onset of action but if it is misused it will easily lead to addiction.
Taking Valium for sleep for longer than 4-6 weeks and with a dose more than acceptable even with a doctor’s prescription will lead to addiction to the drug.
Symptoms of Valium addiction:
- Feeling the need to have more pills to reach the desired effect.
- Craving for the drug before the time for the next dose.
- Become isolated from family and friends.
- Continuation in using the drug although has caused me many problems.
- Loss of interest in any activities or work.
- Ignoring the must-do things.
Even though you must not stop the drug from your own, Valium can cause very serious withdrawal symptoms that may lead to coma and even death.
Valium should be reduced gradually under the supervision of a doctor.
“Taking up to 60 tablets per day was not enough anymore to reach euphoria they were barely enough to reach somehow normal”
Valium is more likely to be used for those who struggle with the daily stress which affects their sleeping quality, it gives them calmness and euphoria especially with high doses, and those who are most vulnerable to addiction.
“Valium was making me not caring for the world anymore even if the house got on fire, I would say so what?!”
Overdosing is highly dangerous as it may lead to:
- Bluish lips.
- Double vision.
- Difficulty breathing.
- General weakness.
- Difficulty in coordination.
“Benzodiazepines (tranquilizers like Valium and Xanax) and opioids (it is a class of drugs that include illegal heroin, synthetic opioids such as fentanyl, and pain relievers legally available by a prescription like oxycodone, hydrocodone, codeine, morphine, and many others) strengthen each other giving higher effects of both of them but they can also cause death.”
– Dr. Michael Kelley, NPR, 2014
Valium may also counteract with some food like grapefruit, consuming large amounts of grapefruit or grapefruit juice strengthen the effects of Valium and can cause serious side effects.
Side effects:
- Severe allergic reaction.
- Hives (Urticaria).
- Difficulty breathing.
- Swelling of face, lips, tongue, and throat.
- Severe drowsiness or dizziness.
- Mood or behavior changes.
- Anxiety, depression, or worsening of both of them.
- Suicidal thoughts.
- Sleeping problems.
In 2011, 14.7 million prescriptions of Valium were written to patients.
Abuse of Valium was first noticed in 2013 as 1.2 million persons were reported to have abused Valium.
Addiction rehab centers are always there for those who fall into addiction with the help of very good and specialized doctors and psychiatrists.
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Valium is a very potent and effective drug but has a lot of safety issues which you should know before starting to use it.
How to buy valium online legally?
Special Alerts about benzodiazepines use
The FDA (Food and Drug Administration) announces that it is requiring an update to benzodiazepine products’ Boxed Warning to include the risks of misuse, addiction, abuse, withdrawal reactions, and physical dependence to improve their safe use. The FDA is also requiring other changes to the Warnings and Precautions, Drug Abuse and Dependence, and Patient Counseling Information sections of the prescribing information for all benzodiazepine products.
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Risks from concomitant use with opioids:
Concomitant use of benzodiazepines and opioids may result in respiratory depression, profound sedation, coma, and death. Reserve concomitant prescribing only if no alternatives are available. Limit dosages and durations to the minimum required. Follow up on the signs and symptoms of respiratory depression and sedation.
Abuse, misuse, and addiction:
The use of benzodiazepines, including Valium, exposes users to risks of misuse, abuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing Valium and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction.
Dependence and withdrawal reactions:
The continued use of benzodiazepines, including Valium, for several days to weeks can result in significant physical dependence. sudden discontinuation or rapid dosage reduction of Valium after continued use may cause acute withdrawal reactions, which can be life-threatening. To reduce this risk, use a gradual taper to discontinue Valium or reduce the dosage.
Adverse Reactions
Incidence higher than 10%: Nervous system: Drowsiness (23%)
Incidence from 1% to 10%:
- Cardiovascular: Hypotension (1% to 2%), vasodilation (1% to 2%)
- Dermatologic: Skin rash (3%)
- Gastrointestinal: diarrhea (4%) ,abdominal pain (≥1%), dysgeusia (2%)
- Nervous system: emotional lability (≥1%), agitation (≥1%), headache (5%), confusion (≥1%), dizziness (3%), abnormality in thinking (1% to 2%) , euphoria (3%), nervousness (≥1%), speech disturbance (≥1%), pain (≥1%).
- Neuromuscular & skeletal: lack of energy and strength (1% to 2%)
- Respiratory: Asthma (2%), bleeding per nose (3%), nasal congestion (3%), nasal discomfort (6%), inflammation and swelling of the mucous membrane of the nose (≥1%)
Incidence less than 1%:
- Cardiovascular: decrease in heartbeats, syncope.
- Dermatologic: increase sweating of skin, pruritus, urticaria.
- Gastrointestinal: anorexia, vomiting.
- Genitourinary: urinary tract infection
- Hematologic & oncologic: anemia, decrease in white blood cell count.
- Infection: Infection.
- Nervous system: convulsions.
- Neuromuscular & skeletal: hyper muscle activity.
- Respiratory: cough.
Frequency not defined:
- Endocrine & metabolic: Change in libido
- Gastrointestinal: altered salivation, constipation, gastrointestinal distress, hiccups, nausea
- Genitourinary: urinary incontinence, urinary retention
- Hematologic & oncologic: neutropenia
- Hepatic: increase in liver function tests.
- Nervous system: drug dependence, central nervous system depression, depression, anterograde amnesia, drug withdrawal, dysarthria, fatigue, hypoactivity, paradoxical central nervous system stimulation, psychiatric signs and symptoms, vertigo, slurred speech
- Neuromuscular & skeletal: Tremor
- Ophthalmic: Blurred vision, diplopia
Contraindications
- untreated open-angle glaucoma.
- infants <6 months of age.
- myasthenia gravis.
- severe respiratory impairment.
- severe hepatic impairment.
- sleep apnea syndrome.
Pregnancy Considerations
Valium crosses the placenta. Teratogenic effects have been observed with Valium; however, more studies are needed. The incidence of low birth and premature birth weights may be increased following maternal use of Valium.
Hypoglycemia and respiratory problems are common with the neonate following exposure late in pregnancy. Neonatal withdrawal symptoms may occur within days to weeks after birth. Monotherapy with the lowest dose should be considered in women with epilepsy. Avoidance of medications with a high incidence of teratogenic effects is recommended.
Breast-Feeding Considerations
Valium and its metabolites are present in breast milk.
Sedation and weight loss have been observed in some infants exposed to Valium via breast milk.
Valium has a long half-life and may accumulate in the breastfed infant, especially preterm infants or those exposed to chronic maternal doses. Significant accumulation may occur even if the maternal dose is low. A single maternal dose may be compatible with breastfeeding.
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In this article we will review some important information you should know about this medication, what it’s used for, and how it’s used, Let’s go through.
What is diazepam?
Diazepam oral tablet is a drug that’s available as the brand name Valium and also available as a generic drug with lower cost.
Diazepam is also available as a liquid nasal spray, an oral solution, and an intravenous injection.
What is it used for?
Diazepam oral tablet is indicated for the following conditions:
Anxiety
agitation or tremors caused by alcohol withdrawal
Adjuvant therapy for skeletal muscle spasms
Adjuvant therapy for certain types of seizure
Adjuvant therapy means that It may be used as part of combination therapy, you still need to take it with other drugs.
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How does it work?
Diazepam belongs to a class of drugs called benzodiazepines (a group of drugs that has a similar chemical structure, attaches to the same receptors so works similarly, and is often used to treat similar conditions).
Diazepam increases the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that can send signals throughout your nervous system. If you don’t have enough GABA, your body may have anxiety and you may have difficulty falling asleep.
By taking diazepam, GABA will be increased in your body. This will help decrease your restlessness spasms, and/or seizures.
What are the common side effects if you buy diazepam 10mg?
Diazepam can cause mild or severe side effects, but we will go through the common side effects:
Headache
Nausea
Dizziness
Drowsiness
Tremor
Spinning sensation,
Tired feeling or fatigue
Muscle weakness
Inability to control muscle movements
Memory problems
Dry mouth or excessive saliva
Constipation
For more information on the possible side effects of diazepam and if you developed any unusual symptoms, talk with your doctor or pharmacist.
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Before you buy diazepam 10mg
Before starting and during diazepam use, your doctor will put you on monitoring
Liver function: Liver function tests are done to help your doctor decide if diazepam is safe for you and if you need a special dose adjustment.
Kidney function: Kidney function tests are done to help your doctor decide if diazepam is safe for you and if you need a special dose adjustment.
Breathing rate: Your doctor will monitor your breathing rate during treatment as diazepam could make your breathing rate too low.
Mental status: Your doctor will monitor you during treatment as diazepam could cause changes in thinking or memory.
IMPORTANT INFORMATION
- Don’t drink alcohol while taking diazepam, this combination can cause serious side effects. Problems with thinking, judgment and motor skills could happen. It can make you drowsy and cause your breathing to slow down or stop.
Also, your body processes alcohol and this drug in similar bath ways, so if you drink alcohol, diazepam could take longer to get out of your body. This may worsen your side effects.
- Don’t use opioid drugs while taking diazepam, this can cause serious side effects. These can include severe drowsiness, slowed breathing, coma, and death.
- Diazepam may interact with other medications, tell your doctor about any drug you use including prescription drugs and nonprescription drugs, and herbal medicines.
- Don’t begin using new drugs without your doctor’s prescription.
Generally
The information contained here is not absolute, inclusive, or totally complete.
It doesn’t cover all possible uses, precautions, drug or food interactions or side is a prescription drug, we don’t admit this drug is safe or effective for you or it’s not.
Ask your healthcare provider about any information you need to know.
