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Diazepam is a benzodiazepine drug, the widely known family, which works on certain receptors called GABA (gamma amino-butyric acid) in the brain affecting the central nervous system (CNS), and are used for several medical conditions.
They attach to these receptors lowering the sensitivity of the brain to stimulation producing a calming effect.
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Benzodiazepines use:
- Alcohol withdrawal symptoms
- Anxiety
- Muscles spasms and stiffness
- Panic disorder
- Seizures
- Sleep disorders
- To induce sedation and amnesia before surgical operations
Diazepam is on this family, acts in the same way, and is used to treat several medical conditions from these conditions handled by benzodiazepines.
Diazepam has similar uses in adults and children.
Buy diazepam UK next-day delivery if you need it for any of the following cases.
Therapeutic indications of diazepam:
Adults
- Severe anxiety, disabling, and exposing the patient to irritating stress, which happens alone or is associated with insomnia, or with physical and psychiatric illness.
- Cerebral palsy (disorders causing problems with moving, maintaining balance, and posture).
- Muscle spasms and stiffness.
- Adjunctive therapy in certain types of epilepsy.
- Managing the acute symptoms happening with withdrawing alcohol.
- Premedication for the nervous patient before dental procedures.
- Inducing sedation in the ICU (intensive care unit) and before having surgery.
Children
- In some cases, diazepam is used to control tension and irritability in cerebral spasticity (where the muscles become stiff and the movements become jerky and stiff).
- Adjunctive therapy for the muscle spasm caused by a bacterial infection called tetanus.
Before you buy diazepam UK next day delivery, you have to tell your doctor if you have,
- allergy to diazepam, or other inactive ingredients in the pamphlet of the drug
- breathing problems, like shallow or slow breathing which may be severe
- depression accompanied by anxiety or not
- hyperactivity
- phobia (continuous fear from a specific place or situation) or from any other mental illness
- myasthenia gravis (easily weakened or tired muscles)
- sleep apnea (abnormal pauses in breathing during sleep for a short period)
- severe liver disease
- porphyria (a medical condition inherited from the parents causing skin blisters, abdominal pain, and central nervous system disorders)
You have also to inform your health care provider about the following before you buy diazepam UK next day delivery,
- history of alcohol or drug abuse
- heart and lung problems
- having psychological trauma like the death of a relative or a friend
- severe kidney failure
- low blood levels of albumin (a protein made by the liver)
- personality disorder
- arteriosclerosis (low blood flow to the brain)
- breathing difficulties
- depression
- suicidal thoughts or behaviors
- epilepsy
- smoking
Other considerations:
Before you buy diazepam UK next day delivery, consider the following,
- Mental side effects, like agitation, hyperactivity, restlessness, aggressiveness, nightmares, and hallucinations.
All of these side effects may occur with the use of diazepam especially with children and elders, contact your doctor immediately if you experience any of these symptoms.
- Amnesia, temporary memory loss which can happen with diazepam, it can be total or partial amnesia, especially with high doses, you have to contact your doctor at once if you experienced that.
- Dependence, if you feel that you need higher doses and longer duration, this is due to developing dependence on the drug, especially with those having a history of alcohol or drug abuse, you have also to contact your doctor and inform him about that.
- Tolerance, if the drug is not working as well as at the beginning of the treatment, talk to your doctor about that.
- Withdrawal, diazepam should be withdrawn gradually and not stopped suddenly, stopping the drug suddenly, withdrawal symptoms may occur.
Withdrawal symptoms:
- depression
- nervousness
- sleeping difficulties
- irritability
- sweating
- stomach cramps
- diarrhea
- worsening of the symptoms you are treated from is also a sign of withdrawing
- Withdrawal symptoms don’t stop at this point, other symptoms may also occur, mood changes, anxiety, restlessness, and changes in sleeping schedules, this may happen after taking the drug at low doses for a short period.
- If sudden stopping after taking high doses, confusion, hallucinations, shaking, and fast heartbeats may occur.
Driving and using machines:
Diazepam may cause sleepiness and poor coordination that can affect your ability to perform everyday activities, like driving, operating heavy machinery, and taking part in risky activities that can put you or others at risk.
You can only drive while taking diazepam if it is not affecting alertness.
Diazepam and lactose intolerance (a type of sugar):
If you are using diazepam tablets, be aware that they contain lactose, which may cause you problems if you suffer from lactose intolerance.
Buy diazepam UK next day delivery from trusted sources only, online websites may be trusted or non-trusted ones buy diazepam from pharma stores to make sure you are buying them from good places, but always take these drugs under the supervision of a doctor.
Paracetamol and Diazepam
Paracetamol and Diazepam
Two drugs are taken together and there is no problem with it?
Two drugs, one for anxiety and the other one for pain, two that are solving your most irritating drugs, and with no interactions happening.
Yes, these two drugs are Paracetamol and Diazepam.
So, what are Paracetamol and Diazepam?
Let’s go to know them together.
Paracetamol, known in the United States as acetaminophen, the most commonly known drug for pain and fever.
It is known as the safest drug to use, it is safe to be used in pregnant women, breastfeeding, and even in neonates.
Paracetamol is used in many conditions, like headache, muscle aches, arthritis (Swelled and tendered joints, distinctive by pain and stiffness of joints), backache, toothaches, colds, and fevers.
It relieves pain but doesn’t affect the inflammation and swelling of joints.
Warnings:
The maximum dose taken from Paracetamol is 1 gram per dose and 4 grams per day.
Taking care of the dose and knowing the maximum dose is very important to avoid overdosing.
Overdose can cause serious harm, like damaging the liver.
If you drink more than 3 alcoholic drinks per day, or if you are suffering from alcoholic liver disease (liver cirrhosis), you should not use Paracetamol without a consult with your doctor.
If the doctor decided you can take Paracetamol when you are drinking more than 3 alcoholic drinks per day, the maximum dose approved is 2 grams per day.
Using over-the-counter cold, cough, allergy, and pain medications may cause overdose, as most of these drugs contain Paracetamol.
Read the medication guide to make they don’t contain Paracetamol in them.
Interactions:
There are no completely contraindicated drugs to be used with Paracetamol, but there is a list of drugs that cause serious interaction, and an alternative drug should be used.
- lonafarnib
- pexidartinib
- pretomanid
There is another list of drugs that when concomitantly used with Paracetamol, close monitoring is needed.
- apalutamide
- avapritinib
- axitinib
- bupivacaine implant
- busulfan
- dapsone topical
- eltrombopag
- exenatide injectable solution
- exenatide injectable suspension
- flibanserin
- imatinib
- isoniazid
- ivacaftor
- lemborexant
- levonorgestrel oral/ethinylestradiol/ferrous bisglycinate
- lixisenatide
- lomitapide
- midazolam intranasal
- mipomersen
- tazemetostat
- tetracaine
- tinidazole
- warfarin
These are not the only drugs interacting with Paracetamol, always consult with your doctors about the drugs you are taking before taking a new one.
Side effects:
- Angioedema (swelling below the skin, it may be due to an allergy to a trigger or a medicine)
- Disorientation
- Dizziness
- Pruritic maculopapular rash (blisters on a flat and red patch of skin)
- Rash
- Hyperammonemia (Excess ammonia in the blood leading to brain injury and death)
- Stevens-Johnson syndrome (a rare and dangerous disorder of the skin and mucous membrane)
- Urticaria
- Gastrointestinal hemorrhage
- Toxic epidermal necrolysis (a rare and serious skin condition)
- Laryngeal edema (Complication happens as a result of intubation)
- Agranulocytosis (very dangerous blood disorder)
- Leukopenia (low count of white blood cells)
- Neutropenia (lower number of neutrophils than normal, a type of white blood cells)
- Hepatotoxicity
- Liver failure
- Nephrotoxicity (a kidney problem)
- Pneumonitis (inflammation of lung tissues)
What about Diazepam?
Diazepam is a benzodiazepine, used in conditions like anxiety, alcohol withdrawal symptoms, seizures, and muscle spasms.
It is also used in providing sedation before having surgery, a dental procedure, or if sedation is required in the ICU (Intensive care unit).
Diazepam works by affecting certain neurotransmitters calming the brain and nerves.
Warnings:
Opioid medications like hydrocodone, oxymorphone, morphine, codeine, and fentanyl, can cause a serious case of shallow breathing or even stop breathing if used with diazepam.
Diazepam may cause misuse, if you have a history of abuse or addiction to any kind of drugs or alcohol, you have to tell your doctor before taking it.
Diazepam may cause a serious allergic reaction, take care of any signs of hives, swelling of face, lips, and tongue, and rash.
This drug did not prove effectiveness and safety in children younger than 6 months old, so it should not I children younger than 6 months old.
Interactions:
Like Paracetamol, diazepam doesn’t have completely contraindicated with it but has drugs causing serious interactions, and an alternative drug should be used.
- abametapir
- apalutamide
- benzhydrocodone/acetaminophen
- calcium/magnesium/potassium/sodium oxybates
- carbamazepine
- cimetidine
- clarithromycin
- darunavir
- erythromycin base
- erythromycin ethylsuccinate
- erythromycin lactobionate
- erythromycin stearate
- fedratinib
- hydrocodone
- idelalisib
- ivosidenib
- ketoconazole
- lonafarnib
- metoclopramide intranasal
- mifepristone
- nefazodone
- rifabutin
- rifampin
- selinexor
- sodium oxybate
- St John’s Wort
- sufentanil SL
- tipranavir
- tucatinib
- valerian
- voxelotor
Another list of drugs needs close monitoring when used with diazepam, always tell your doctor about drugs you are taking before taking a new one.
Side effects:
There are common and less common side effects, in this article, we will only talk about the common ones.
- Ataxia (a group of disorders affecting balance, coordination, and speech)
- Euphoria
- Incoordination
- Sleeplessness
- Rash
- Diarrhea
Finally, Paracetamol and diazepam have no problem with being used together, there are no interactions between them but always consult with your doctor about the doses and times of taking drugs to accomplish the effectiveness and safety from this interaction.
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Amitriptyline and Diazepam
Amitriptyline and Diazepam
When different drugs are used together, different interactions may occur, like using amitriptyline and diazepam are used together, what is the kind of interaction between them?
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If they have similar actions, additive effects may happen.
If they have opposite actions, canceling effects may happen.
These interactions may cause an increase or decrease in the effectiveness of the drugs or even the side effects.
This happens due to increase or decrease in:
- The absorption of the drug
Like drugs not taken with food as food may affect their absorption as an example, fibers like wheat bran slows down the absorption of digoxin and decreases its effectiveness.
- The distribution of the drug
Like drugs causing others to be freer, not binding to plasma proteins, making their concentration higher, which may cause toxicity, for example, diazepam and phenytoin, diazepam makes phenytoin more available, which increases the risk for toxicity.
- The metabolism of the drug (the alteration of the drug to be excreted outside the body)
Some drugs interact by inducing or inhibiting the enzymes responsible for metabolizing other drugs, which result in an increase or decrease in the concentration of these drugs, for example, Phenytoin and Rifampicin, are enzyme inducers, resulting in the decrease of the interacted drug as they enhance the excretion of it from the body.
- The elimination of the drug
Patients with renal impairment taking drugs excreted through the urine must get altered doses to avoid the accumulation of the drugs in the body leading to toxic doses.
So, what is amitriptyline, and what is diazepam, and what is the kind of interaction between amitriptyline and diazepam?
Amitriptyline belongs to a family of drugs called tricyclic antidepressants.
It is used in mental and mood problems, like depression.
Amitriptyline helps in relieving anxiety and tension, improving mood, sleeping better, and increasing your level of energy.
It works by affecting certain neurotransmitters in the brain like serotonin.
Amitriptyline is also used in certain eating disorders and migraine headaches.
There are also off-label uses of amitriptyline:
- Increase in the production of saliva
- Sleeping problems
- Irritable bowel syndrome (gastrointestinal disorder causing chronic discomfort)
- Neuralgia caused after the infection of herpes zoster
Neuralgia is caused by damaged or diseased nerves, leading to burning, stabbing pains, or aches.
- Chronic pain
- Interstitial cystitis (bladder problem causing pain and pressure in the pelvis, bladder, also causing urinary frequency or urgency)
- Migraine (severe and recurrent headache)
- Anxiety
- Post-traumatic stress disorder (disorder happening after a traumatic event like feeling extreme fear, shock, or helplessness)
Dosage and administration:
Amitriptyline is found in tablet form with many concentrations.
Depression
25 – 50 mg initially, increased by 25 mg every 5 – 7 days, till reaching 100 – 200 mg per day.
The dose may be divided through the day or just taken at bedtime.
If needed, the dose may be increased to 300 mg per day.
Neuralgia caused after the infection with herpes zoster
65 – 100 mg per day, and it is used for at least 3 weeks.
Migraine
10 – 25 mg per day.
The dose may range from 10 to 400 mg per day.
Eating disorder
150 mg per day for 8 weeks.
Contraindicated drugs:
Drugs that should never be used with amitriptyline.
- disopyramide
- dronedarone
- ibutilide
- indapamide
- iobenguane I 123
- isocarboxazid
- pentamidine
- phenelzine
- pimozide
- procainamide
- procarbazine
- quinidine
- safinamide
- selegiline
- sotalol
- tranylcypromine
What about Diazepam?
Diazepam is one of a very famous family called benzodiazepines.
It is used in treating anxiety, alcohol withdrawal symptoms, seizures, providing sedation in the ICU (intensive care unit), providing sedation before having surgery, relaxation of spastic muscles, and in status epilepticus.
Dosage and administration:
Diazepam is available in many dosage forms, tablets, oral solutions, rectal gels, injectable solutions, and intramuscular devices, with many different concentrations.
Anxiety
2 – 10 mg every 6 – 12 hours.
Maximum dose: 30 mg every 8 hours
Alcohol withdrawal symptoms
10 mg every 6 – 12 hours during the first 24 hours.
The dose is reduced to 5 mg every 6 – 8 hours.
Muscle spasms
2 – 10 mg every 6 – 8 hours.
There are no completely contraindicated drugs with diazepam, but drugs are causing serious interactions, and you have to use an alternative drug.
Serious interactions causing drugs:
- abametapir
- apalutamide
- benzhydrocodone/acetaminophen
- calcium/magnesium/potassium/sodium oxybates
- carbamazepine
- cimetidine
- clarithromycin
- darunavir
- erythromycin base
- erythromycin ethylsuccinate
- erythromycin lactobionate
- erythromycin stearate
- fedratinib
- hydrocodone
- idelalisib
- ivosidenib
- ketoconazole
- lonafarnib
- metoclopramide intranasal
- mifepristone
- nefazodone
- rifabutin
- rifampin
- selinexor
- sodium oxybate
- St John’s Wort
- sufentanil SL
- tipranavir
- tucatinib
- valerian
- voxelotor
Amitriptyline and diazepam together may cause increased side effects, like dizziness, drowsiness, confusion, and concentration difficulties.
Elder patients especially experience thinking and judgment impairment, and problems with coordination.
Alcohol is really dangerous if used with amitriptyline and diazepam.
Driving and operating heavy machinery should not be performed unless making sure about how the drug will affect the patient.
Always confirm with your doctor the information mentioned in a medical article.
Cheap Valium Uk
Cheap Valium Uk
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The active constituent of Valium is diazepam which belongs to the benzodiazepine group, it is used for treating anxiety, spasticity, epilepsy and as anxiolytic before operations.
The recommended dose of diazepam:
In adults
- Anxiety or mental health problems: start with 5mg to a maximum dose of 30mg each day, in divided doses.
- To help you sleep: 5mg-15mg at bedtime.
- With cerebral palsy or other spasticities: the dose may range from 5mg to 60mg each day, in divided doses.
- To control muscle spasms: start with a dose of 5mg to reach 15mg each day, in divided doses.
- To help epilepsy: start with a dose of 2mg to a maximum of 60mg each day, in divided doses.
- To help with alcohol withdrawal symptoms: 5mg to 20mg, which may be repeated after 2 to 4 hours if necessary.
- Before dental treatment: you can take valium tablets 5mg the night before treatment and 5mg on waking and 5mg two hours before the appointment.
- Before an operation: 5mg-20mg
Use in children
For tension and irritability associated with cerebral spasticity: 5mg to 40mg each day, in divided doses.
As an anxiolytic before an operation by a dose of 2mg-10mg.
Elderly or Frail
The effect of valium may be exaggerated If you are elderly or frail such as confusion, and your doctor will prescribe lower doses to you. The dose in these situations cannot exceed half the adult dose.
Kidney or liver impairment
Valium tablets may accumulate in your body in case of liver or kidney problems. you may need a lower dose.
How to take valium tablets?
Always follow the instructions of your doctor about Valium, do not change the dose by yourself. Make sure that you take this medicine exactly as your doctor or pharmacist has told you.
Always remember that cheap Valium uk tablets are available at pharmastores.net. know that Valium tablets cannot be taken for longer than 4 weeks. Do not crush Valium tablets, Swallow them whole, with a glass of water.
Valium overdose
if you take more valium tablets than you should or If you (or someone else) swallow a lot of valium tablets at the same time, or you think a child may have swallowed any, tell your doctor immediately.
Signs of an overdose
- Clumsiness and loss of coordination
- Feeling sleepy or deep sleep
- Speech problems
- Irregular or slow heartbeat
- Uncontrolled eye movement
- Muscle weakness or excitement
- Coma in case of extreme overdose (unrousable unconsciousness), breathing difficulties and reflex problems.
Missed doses
Do not take double the dose of valium tablets to make up for a forgotten dose.
Examples of drugs that can interact with valium:
- Isoniazid (antiuburcolosis drug)
- Oral contraceptives, breakthrough bleeding can occur if you take valium with oral contraceptives.
- Cisapride can decrease the effect of diazepam by accelerating its elimination from the body.
- Levodopa (used to treat Parkinson’s disease).
- Valproic acid (antiepileptic drug).
- ketamine (an anaesthetic).
- Nabilone (to treat nausea and vomiting).
- Alpha-blockers, beta-blockers (antihypertensive drugs).
Valium and opioids
Concomitant use of valium tablets and opioids (strong painkillers) increases the risk of difficulties in breathing (respiratory depression), drowsiness, coma and may be life-threatening, so use them together if the other options are not available.
Your doctor will limit the duration and doses in case of concomitant use.
Do not forget to tell your doctor about all the medicines you take as some types of these opioids can be a part of cough suppressants OTC preparation.
Valium UK tablets with food and drink
Avoid drinking alcohol while taking diazepam as alcohol increases the sedative effect of diazepam and makes you drowsy. Some food can also increase the concentration of diazepam in your blood like grapefruit juice. If you are older than 65 years or suffer from liver disease, this could possibly increase the sedative effects of valium tablets and you should speak to your doctor or pharmacist. Drinks containing caffeine may reduce the effects of valium.
Pregnancy, breast-feeding and fertility
Do not take valium UK tablets if you are pregnant, or planning to be pregnant or breastfeeding. If you take valium near the end of your pregnancy (or during labour) this may harm your baby like low temperature, be restless, difficulty in feeding, have breathing problems.
Driving and using machines
Valium tablets can affect daily normal activities as they may make you sleepy, forgetful, have poor coordination, so you should not operate machinery, or drive, or take part in any activities that require a high level of concentration.
Stopping valium tablets and Withdrawal Effects
You should not stop valium tablets suddenly your doctor will taper the dose according to your tolerance and response.
Withdrawal symptoms can occur If you stop taking valium tablets suddenly such as:
- depression
- nervousness
- difficulty in sleeping
- irritability
- sweating
- upset stomach/diarrhoea
You may also experience anxiety, mood changes, restlessness and changes in sleep patterns. These effects may occur even with a short duration of use and small doses.
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Using valium for sleep
Valium for sleep
Tranquilizers
are a group of drugs that are used to control anxiety, fear, tension, agitation, and any other mental problems.
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It can be either:
Minor tranquilizers: Anxiolytics (medication reduces anxiety).
Major tranquilizers: Antipsychotics (medication used to manage psychosis which affects how the brain functions).
Valium for sleep is one of the minor tranquilizers that are used for treating anxiety, alcohol withdrawal symptoms, and muscle spasms or stiffness.
Valium is used to treat seizures in combination with other medicines.
It works by controlling the hyperactivity of brain function to relieve severe stress and anxiety.
Valium must be taken under a doctor’s supervision as its dose changes according to the patient’s condition, age, and response to medication and the dose must never be increased by yourself as it may cause some serious side effects and overdose effect as we will discuss later in this article.
You can use valium for sleep and it should be individualized for better effects and the least side effects.
Usual daily doses:
Anxiety: 2mg to 10 mg from 2 to 4 times daily according to the condition.
Alcohol withdrawal: 10 mg 3 to 4 times for the first day then reduced to 5 mg 3 to 4 times daily.
Muscle spasms or stiffness: 2 to 10 mg 3 to 4 times daily.
Elder patients: 2 mg to 2.5 mg, 1 or 2 times daily the can be increased gradually as needed.
Dosage modifications:
if you want to use valium for sleep, please take care if you are suffering from:
Renal impairment: No modification is needed unless for prolonged treatment decrease in dose is recommended.
Hepatic impairment: 50% of the dose should be given only.
You must tell your doctor if you suffer from any of the following medical conditions before you start taking Valium for sleep as they may interfere with the drug:
-
Myasthenia gravis (a disorder of muscle weakness).
-
Severe breathing problems.
-
Sleep apnoea (stop breathing during sleep for short time).
-
Narrow-angle glaucoma.
-
Uncontrolled open-angle glaucoma.
-
Severe liver diseases.
-
Allergy to it.
-
Drug or Alcohol addiction.
-
Any kind of depression including (mood changes or suicidal thoughts).
-
Seizures unless you are taking it for a seizure disorder.
Valium for sleep is a long-acting medication compared to other drugs with the same action; it takes from 30 to 56 hours to get out from the body.
Valium for sleep is very effective, potent, and has a fast onset of action but if it is misused it will easily lead to addiction.
Taking Valium for sleep for longer than 4-6 weeks and with a dose more than acceptable even with a doctor’s prescription will lead to addiction to the drug.
Symptoms of Valium addiction:
- Feeling the need to have more pills to reach the desired effect.
- Craving for the drug before the time for the next dose.
- Become isolated from family and friends.
- Continuation in using the drug although has caused me many problems.
- Loss of interest in any activities or work.
- Ignoring the must-do things.
Even though you must not stop the drug from your own, Valium can cause very serious withdrawal symptoms that may lead to coma and even death.
Valium should be reduced gradually under the supervision of a doctor.
“Taking up to 60 tablets per day was not enough anymore to reach euphoria they were barely enough to reach somehow normal”
Valium is more likely to be used for those who struggle with the daily stress which affects their sleeping quality, it gives them calmness and euphoria especially with high doses, and those who are most vulnerable to addiction.
“Valium was making me not caring for the world anymore even if the house got on fire, I would say so what?!”
Overdosing is highly dangerous as it may lead to:
- Bluish lips.
- Double vision.
- Difficulty breathing.
- General weakness.
- Difficulty in coordination.
“Benzodiazepines (tranquilizers like Valium and Xanax) and opioids (it is a class of drugs that include illegal heroin, synthetic opioids such as fentanyl, and pain relievers legally available by a prescription like oxycodone, hydrocodone, codeine, morphine, and many others) strengthen each other giving higher effects of both of them but they can also cause death.”
– Dr. Michael Kelley, NPR, 2014
Valium may also counteract with some food like grapefruit, consuming large amounts of grapefruit or grapefruit juice strengthen the effects of Valium and can cause serious side effects.
Side effects:
- Severe allergic reaction.
- Hives (Urticaria).
- Difficulty breathing.
- Swelling of face, lips, tongue, and throat.
- Severe drowsiness or dizziness.
- Mood or behavior changes.
- Anxiety, depression, or worsening of both of them.
- Suicidal thoughts.
- Sleeping problems.
In 2011, 14.7 million prescriptions of Valium were written to patients.
Abuse of Valium was first noticed in 2013 as 1.2 million persons were reported to have abused Valium.
Addiction rehab centers are always there for those who fall into addiction with the help of very good and specialized doctors and psychiatrists.
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Valium is a very potent and effective drug but has a lot of safety issues which you should know before starting to use it.
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Special Alerts about benzodiazepines use
The FDA (Food and Drug Administration) announces that it is requiring an update to benzodiazepine products’ Boxed Warning to include the risks of misuse, addiction, abuse, withdrawal reactions, and physical dependence to improve their safe use. The FDA is also requiring other changes to the Warnings and Precautions, Drug Abuse and Dependence, and Patient Counseling Information sections of the prescribing information for all benzodiazepine products.
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Risks from concomitant use with opioids:
Concomitant use of benzodiazepines and opioids may result in respiratory depression, profound sedation, coma, and death. Reserve concomitant prescribing only if no alternatives are available. Limit dosages and durations to the minimum required. Follow up on the signs and symptoms of respiratory depression and sedation.
Abuse, misuse, and addiction:
The use of benzodiazepines, including Valium, exposes users to risks of misuse, abuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing Valium and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction.
Dependence and withdrawal reactions:
The continued use of benzodiazepines, including Valium, for several days to weeks can result in significant physical dependence. sudden discontinuation or rapid dosage reduction of Valium after continued use may cause acute withdrawal reactions, which can be life-threatening. To reduce this risk, use a gradual taper to discontinue Valium or reduce the dosage.
Adverse Reactions
Incidence higher than 10%: Nervous system: Drowsiness (23%)
Incidence from 1% to 10%:
- Cardiovascular: Hypotension (1% to 2%), vasodilation (1% to 2%)
- Dermatologic: Skin rash (3%)
- Gastrointestinal: diarrhea (4%) ,abdominal pain (≥1%), dysgeusia (2%)
- Nervous system: emotional lability (≥1%), agitation (≥1%), headache (5%), confusion (≥1%), dizziness (3%), abnormality in thinking (1% to 2%) , euphoria (3%), nervousness (≥1%), speech disturbance (≥1%), pain (≥1%).
- Neuromuscular & skeletal: lack of energy and strength (1% to 2%)
- Respiratory: Asthma (2%), bleeding per nose (3%), nasal congestion (3%), nasal discomfort (6%), inflammation and swelling of the mucous membrane of the nose (≥1%)
Incidence less than 1%:
- Cardiovascular: decrease in heartbeats, syncope.
- Dermatologic: increase sweating of skin, pruritus, urticaria.
- Gastrointestinal: anorexia, vomiting.
- Genitourinary: urinary tract infection
- Hematologic & oncologic: anemia, decrease in white blood cell count.
- Infection: Infection.
- Nervous system: convulsions.
- Neuromuscular & skeletal: hyper muscle activity.
- Respiratory: cough.
Frequency not defined:
- Endocrine & metabolic: Change in libido
- Gastrointestinal: altered salivation, constipation, gastrointestinal distress, hiccups, nausea
- Genitourinary: urinary incontinence, urinary retention
- Hematologic & oncologic: neutropenia
- Hepatic: increase in liver function tests.
- Nervous system: drug dependence, central nervous system depression, depression, anterograde amnesia, drug withdrawal, dysarthria, fatigue, hypoactivity, paradoxical central nervous system stimulation, psychiatric signs and symptoms, vertigo, slurred speech
- Neuromuscular & skeletal: Tremor
- Ophthalmic: Blurred vision, diplopia
Contraindications
- untreated open-angle glaucoma.
- infants <6 months of age.
- myasthenia gravis.
- severe respiratory impairment.
- severe hepatic impairment.
- sleep apnea syndrome.
Pregnancy Considerations
Valium crosses the placenta. Teratogenic effects have been observed with Valium; however, more studies are needed. The incidence of low birth and premature birth weights may be increased following maternal use of Valium.
Hypoglycemia and respiratory problems are common with the neonate following exposure late in pregnancy. Neonatal withdrawal symptoms may occur within days to weeks after birth. Monotherapy with the lowest dose should be considered in women with epilepsy. Avoidance of medications with a high incidence of teratogenic effects is recommended.
Breast-Feeding Considerations
Valium and its metabolites are present in breast milk.
Sedation and weight loss have been observed in some infants exposed to Valium via breast milk.
Valium has a long half-life and may accumulate in the breastfed infant, especially preterm infants or those exposed to chronic maternal doses. Significant accumulation may occur even if the maternal dose is low. A single maternal dose may be compatible with breastfeeding.
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In this article we will review some important information you should know about this medication, what it’s used for, and how it’s used, Let’s go through.
What is diazepam?
Diazepam oral tablet is a drug that’s available as the brand name Valium and also available as a generic drug with lower cost.
Diazepam is also available as a liquid nasal spray, an oral solution, and an intravenous injection.
What is it used for?
Diazepam oral tablet is indicated for the following conditions:
Anxiety
agitation or tremors caused by alcohol withdrawal
Adjuvant therapy for skeletal muscle spasms
Adjuvant therapy for certain types of seizure
Adjuvant therapy means that It may be used as part of combination therapy, you still need to take it with other drugs.
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How does it work?
Diazepam belongs to a class of drugs called benzodiazepines (a group of drugs that has a similar chemical structure, attaches to the same receptors so works similarly, and is often used to treat similar conditions).
Diazepam increases the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that can send signals throughout your nervous system. If you don’t have enough GABA, your body may have anxiety and you may have difficulty falling asleep.
By taking diazepam, GABA will be increased in your body. This will help decrease your restlessness spasms, and/or seizures.
What are the common side effects if you buy diazepam 10mg?
Diazepam can cause mild or severe side effects, but we will go through the common side effects:
Headache
Nausea
Dizziness
Drowsiness
Tremor
Spinning sensation,
Tired feeling or fatigue
Muscle weakness
Inability to control muscle movements
Memory problems
Dry mouth or excessive saliva
Constipation
For more information on the possible side effects of diazepam and if you developed any unusual symptoms, talk with your doctor or pharmacist.
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Before you buy diazepam 10mg
Before starting and during diazepam use, your doctor will put you on monitoring
Liver function: Liver function tests are done to help your doctor decide if diazepam is safe for you and if you need a special dose adjustment.
Kidney function: Kidney function tests are done to help your doctor decide if diazepam is safe for you and if you need a special dose adjustment.
Breathing rate: Your doctor will monitor your breathing rate during treatment as diazepam could make your breathing rate too low.
Mental status: Your doctor will monitor you during treatment as diazepam could cause changes in thinking or memory.
IMPORTANT INFORMATION
- Don’t drink alcohol while taking diazepam, this combination can cause serious side effects. Problems with thinking, judgment and motor skills could happen. It can make you drowsy and cause your breathing to slow down or stop.
Also, your body processes alcohol and this drug in similar bath ways, so if you drink alcohol, diazepam could take longer to get out of your body. This may worsen your side effects.
- Don’t use opioid drugs while taking diazepam, this can cause serious side effects. These can include severe drowsiness, slowed breathing, coma, and death.
- Diazepam may interact with other medications, tell your doctor about any drug you use including prescription drugs and nonprescription drugs, and herbal medicines.
- Don’t begin using new drugs without your doctor’s prescription.
Generally
The information contained here is not absolute, inclusive, or totally complete.
It doesn’t cover all possible uses, precautions, drug or food interactions or side is a prescription drug, we don’t admit this drug is safe or effective for you or it’s not.
Ask your healthcare provider about any information you need to know.
